A5001426192- Cardiac electrophysiology and arrhythmias
- RNA modifications and cancer
- Respiratory viral infections research
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- RNA Research and Splicing
- Nitric Oxide and Endothelin Effects
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Phosphodiesterase function and regulation
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Pulmonary Hypertension Research and Treatments
Liaoning University of Traditional Chinese Medicine
2024-2025
Jiangsu Agri-animal Husbandry Vocational College
2025
Johns Hopkins Medicine
2019-2023
Johns Hopkins University
2019-2023
Northwest University
2023
Xi'an Medical University
2009-2022
Medical Center Hospital
2022
Xian Central Hospital
2020-2022
Shanghai First Maternity and Infant Hospital
2016-2020
Temple University
2019
Abstract Traumatic brain injury (TBI) is a universal leading cause of long-term neurological disability and causes huge burden to an ever-growing population. Moderate intensity treadmill exercise has been recognized as efficient intervention combat TBI-induced motor cognitive disorders, yet the underlying mechanism still unclear. Ferroptosis known be highly implicated in TBI pathophysiology, anti-ferroptosis effects have reported other diseases except for TBI. In addition cytokine induction,...
Background As an integral part of the tumor microenvironment (TME), tumor-associated neutrophils play a crucial role in development. The objective this study was to investigate plasticity N1 and N2 TME pancreatic ductal adenocarcinoma (PDAC), along with its impact on survival association immune infiltrations. Methods primary validation cohorts including 90 radical resection patients from September 2012 May 2016 29 2018 October 2019, respectively, complete data, were enrolled....
Brain natriuretic peptide (BNP) belongs to the family of peptides, which are responsible for a wide range actions. Diabetic cardiomyopathy (DCM) is often associated with increased BNP levels. This present research intends explore role in development DCM and underlying mechanisms. Diabetes was induced mice using streptozotocin (STZ). Primary neonatal cardiomyocytes were treated high glucose. It found that levels plasma started increase at 8 weeks after diabetes, preceded DCM. Addition...
Important biological and pathologic properties are often conserved across species. Although several mouse leukemia models have been well established, the genes deregulated in both human murine cells not studied systematically. We performed a serial analysis of gene expression MLL-ELL or MLL-ENL identified 88 that seemed to be significantly types cells, including 57 reported previously as being MLL-associated leukemias. These changes were validated by quantitative PCR. The most up-regulated...
This is the first and largest prospective, multicenter, active, population-based surveillance study of epidemiology Mycoplasma pneumoniae among outpatient children with mild respiratory tract infections (RTIs) during COVID-19 pandemic. Nationwide measures like strict face mask wearing restrictions on population movement implemented to prevent spread might also effectively M. .
This study assessed the immunogenicity and safety of a quadrivalent influenza split-virion vaccine (IIV4) in children with without prior vaccination. An open-label, phase IV clinical trial was conducted healthy aged 3–8 years Pizhou, Jiangsu Province, China. Children ≥2 doses vaccination (Influenza Vaccination Group) those no Vaccine-naïve were given two IIV4, 4 weeks apart. The primary endpoints seroprotection rates (SPRs) hemagglutination inhibition antibody 28 days after each dose against...
Diabetes mellitus increases morbidity/mortality of ischemic heart disease. Although atrial natriuretic peptide and C-type reduce the myocardial ischemia-reperfusion damage in nondiabetic rats, whether vasonatrin (VNP), artificial synthetic chimera peptide, confers cardioprotective effects against injury, especially diabetic patients, is still unclear. This study was designed to investigate VNP on injury rats further elucidate its mechanisms. The high-fat diet-fed streptozotocin-induced...
Background: The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains dismally poor and is widely considered as an intricate genetic disorder. mutational landscape PDAC may directly reflect cancer immunogenicity dictate the extent phenotype immune cell infiltration. In adverse, microenvironment also effect gene expression cells, which associated with clinical prognosis. Thus, it crucial to identify genomic alterations in its impacts on Methods: profiles, mutation data information 179...
Fetal growth restriction (FGR) contributes the primary cause of perinatal mortality and morbidity with impacts on long-term health. To determine core gene expression network signatures, which in combination ultrasound confirmation will more effectively differentiate constitutionally normal small for gestational age pathological FGR groups, we performed RNA sequencing protein-coding genes, lncRNAs, RNAs a case-control study umbilical cord blood. Five pairs case control blood samples were used...
Abstract Background Diabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), nucleotide exchange factor, shown regulate mitochondrial import process maintain homeostasis. However, the effect and mechanism of Grpel2 DCM remain unknown. Methods The streptozotocin (STZ)-induced mice model high glucose (HG)-treated cardiomyocytes were established. Overexpression cardiac-specific was performed by intramyocardial injection...
The aim of this study was to evaluate the cardiovascular and renal activities a newly designed natriuretic peptide (NP). Here, we engineered novel 28-amino acid chimeric peptide, termed AC-NP that combined 17-amino ring C type (CNP) with 6-amino N-terminus 5-amino C-terminus atrial (ANP). Both in vitro vivo experiments were performed determine actions AC-NP. In normal rats, proved be more potentially diuretic, hypotensive compared other NPs, such as ANP, CNP vasonatrin (VNP), which is...