A5074009995- Cardiac Ischemia and Reperfusion
- Sirtuins and Resveratrol in Medicine
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Cardiac electrophysiology and arrhythmias
- Berberine and alkaloids research
- Nitric Oxide and Endothelin Effects
- Autophagy in Disease and Therapy
- PARP inhibition in cancer therapy
- Circular RNAs in diseases
- Aortic Disease and Treatment Approaches
- RNA regulation and disease
- Garlic and Onion Studies
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Phagocytosis and Immune Regulation
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Congenital Diaphragmatic Hernia Studies
- Mitochondrial Function and Pathology
- Alcohol Consumption and Health Effects
General Hospital of Shenyang Military Region
2016-2025
Tianjin University
2024
Northern Hospital
2023
Ningxia Medical University
2017-2023
Weihai Municipal Hospital
2013-2020
Jimo District Qingdao Hospital of Traditional Chinese Medicine
2020
Ningxia Medical University General Hospital
2019
Command Hospital
2019
Shenyang 242 Hospital
2018
Air Force Medical University
2012-2017
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is member the sirtuin that localized primarily to mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has favorable effect in ameliorating MI/R We hypothesized melatonin injury by activating SIRT3 signaling pathway. In this study, mice were pretreated with or without...
Abstract Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion ( MI / R ) injury by reducing oxidative stress. Activation of silent information regulator 1 SIRT 1) signaling also reduces injury. We hypothesize that melatonin may protect activating signaling. This study investigated the protective treatment on heart and elucidated its potential mechanisms. Rats were exposed to in presence or absence receptor antagonist luzindole inhibitor EX 527 then subjected...
Abstract Enhancing mitochondrial biogenesis and reducing oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial ischemia/reperfusion (MI/R) injury. Melatonin has been reported be a safe potent cardioprotective agent. However, its role on or reactive oxygen species (ROS) production in type 1 myocardium the underlying mechanisms remain unknown. We hypothesize that melatonin ameliorates MI/R injury rats by preserving function via AMPK-PGC-1α-SIRT3...
Abstract Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying mechanisms remain largely undefined. Activation of SIRT6 and membrane receptors exerts cardioprotective effects while little is known about their roles during DCM. Using high‐fat diet‐streptozotocin‐induced rat model, we that prolonged diabetes significantly decreased nocturnal circulatory heart levels, reduced expressions cardiac...
Diabetes mellitus (DM) increases myocardial oxidative stress and endoplasmic reticulum (ER) stress. Melatonin confers cardioprotective effect by suppressing damage. However, the mechanism of melatonin on ischemia-reperfusion (MI/R) injury in type 2 diabetic state are still unknown. In this study, we developed high-fat diet-fed streptozotocin (HFD-STZ) rat, a well-known model, to evaluate MI/R with focus silent information regulator 1 (SIRT1) signaling, stress, PERK/eIF2α/ATF4-mediated ER...
Berberine (BBR) exerts potential protective effect against myocardial ischemia/reperfusion (MI/R) injury. Activation of silent information regulator 1 (SIRT1) signaling attenuates MI/R injury by reducing oxidative damage and inflammation response. This study investigated the antioxidative anti‐inflammatory effects BBR treatment in condition elucidated its mechanisms. Sprague‐Dawley rats were treated with absence or presence SIRT1 inhibitor sirtinol (Stnl) then subjected to conferred...
Abstract Melatonin confers profound protective effect against myocardial ischemia–reperfusion injury ( MI / RI ). Activation of N otch1/ H airy and enhancer split 1 es1) signaling also ameliorates . We hypothesize that melatonin attenuates ‐induced oxidative damage by activating es1 pathway with phosphatase tensin homolog deleted on chromosome 10 P ten)/ A kt acting as the downstream in a membrane receptor‐dependent manner. Male S prague D awley rats were treated (10 mg/kg/day) for 4 wk then...
Naringenin directly inhibits mitochondrial oxidative stress damage and preserves biogenesis<italic>via</italic>AMPK-SIRT3 signaling, thus attenuating MI/R injury.
The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is increasingly common as aging-related diseases. However, little known about mechanisms responsible for remodeling in AD pathogenesis. α7 nicotinic acetylcholine receptors (α7nAChR) has been shown to have profound effects on mitochondrial oxidative stress both organ Here, we investigate the role α7nAChR mediating amyloid-β (Aβ) cultured mouse cardiomyocytes (HL-1 cells) model mice (APP/PS1). In vitro,...
Abstract Stress hyperglycemia is commonly observed in patients suffering from ischemic heart disease. It not only worsens cardiovascular prognosis but also attenuates the efficacies of various cardioprotective agents. This study aimed to investigate protective effect melatonin against myocardial ischemia‐reperfusion ( MI /R) injury acute hyperglycemic state with a focus on Notch1/Hes1/Akt signaling and intracellular thioredoxin (Trx) system. Sprague Dawley rats were subjected /R surgery...
Diabetes exacerbates oxidative/nitrative stress during myocardial ischemia‐reperfusion (MI/R) injury. Recent studies highlighted the cardioprotective actions of polydatin. However, its effect on diabetic MI/R injury and underlying mechanisms remain unknown. This work was undertaken to evaluate polydatin with a focus Notch1/Hes1 signaling stress. Streptozotocin‐ (STZ‐) induced rats were administered (20 mg/kg/d) in absence or presence DAPT (a γ ‐secretase inhibitor) LY294002 PI3K/Akt then...
Endoplasmic reticulum (ER) stress and oxidative contribute greatly to myocardial ischemia-reperfusion (MI/R) injury. Naringenin, a flavonoid derived from the citrus genus, exerts cardioprotective effects. However, effects of naringenin on ER as well under MI/R condition detailed mechanisms remain poorly defined. This study investigated protective effect MI/R-injured heart with focus cyclic guanosine monophosphate- (cGMP-) dependent protein kinase (PKG) signaling. Sprague-Dawley rats were...
Myocardial infarction (MI) is regarded as a serious ischemic heart disease on global level. The current study set out to explore the mechanism of Notch signaling pathway in regulation fibrosis remodeling after occurrence MI. First, experimental mice were infected with recombination signal binding protein J (RBP-J) shRNA and empty adenovirus vector, followed by establishment MI mouse models detection cardiac function. After 4 weeks MI, sh-RBP-J group found exhibit significantly improved...
This study examines the relationship between Hb, RDW and their association both short-term long-term mortality in patients with acute aortic dissection (AAD), aiming to establish combined effect Hb as a potential prognostic biomarker for AAD outcomes. We extracted clinical data from Medical Information Mart Intensive Care (MIMIC) databases this analysis. Using adjusted Cox regression Kaplan-Meier survival curve analyses, we assessed at admission multiple post-discharge intervals (30 days, 90...
Diabetes mellitus increases morbidity/mortality of ischemic heart disease. Although atrial natriuretic peptide and C-type reduce the myocardial ischemia-reperfusion damage in nondiabetic rats, whether vasonatrin (VNP), artificial synthetic chimera peptide, confers cardioprotective effects against injury, especially diabetic patients, is still unclear. This study was designed to investigate VNP on injury rats further elucidate its mechanisms. The high-fat diet-fed streptozotocin-induced...