A5077791798- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Protease and Inhibitor Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- GDF15 and Related Biomarkers
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- RNA regulation and disease
- Circular RNAs in diseases
- Inflammation biomarkers and pathways
- Hereditary Neurological Disorders
- Nuclear Receptors and Signaling
- Cancer Immunotherapy and Biomarkers
Kunming University of Science and Technology
2023-2025
First People's Hospital of Yunnan Province
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2024
Yangtze University
2024
Zhengzhou People's Hospital
2023
China Medical University
2023
First Hospital of China Medical University
2023
Air Force Medical University
2010-2020
UCSI University
2018
Abstract Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion ( MI / R ) injury by reducing oxidative stress. Activation of silent information regulator 1 SIRT 1) signaling also reduces injury. We hypothesize that melatonin may protect activating signaling. This study investigated the protective treatment on heart and elucidated its potential mechanisms. Rats were exposed to in presence or absence receptor antagonist luzindole inhibitor EX 527 then subjected...
Introduction: Glioma is the most common primary brain tumor. The small nucleolar RNA host gene (SNHG) SNHG6 a potential oncogene in development of several types cancers. Methods: In this study, we investigated functional role long non-coding (lncRNA) malignancy glioma cell lines and transplanted nude mice. Results: We found that expression lncRNA was higher tissues cells than normal cells. positively correlated with poor prognosis patients. microRNA (miR)-101-3p decreased negatively tissues,...
ABSTRACT Incomplete Miller‐Fisher syndrome (MFS) is a rare autoimmune disorder affecting the nervous system. In contrast to classical MFS, its clinical manifestations are often atypical and may be characterized by absence of certain features, such as extraocular muscle paralysis loss tendon reflexes. The presence anti‐GD3 antibodies infrequently observed in these patients. This case report describes patient diagnosed with incomplete MFS who exhibited positive antibody results presented...
Background Albiflorin isolated from Paeoniae Alba Radix can cross the blood–brain barrier (BBB) and possesses analgesia, anticonvulsant, anti-inflammatory, hepatoprotective properties. This study investigates albiflorin functions related mechanisms in Parkinson's disease (PD) pathogenesis.
Chronic stress can impact brain function through various mechanisms, contributing to the development of anxiety disorders. unpredictable mild (CUMS) is a well-established model for studying effects chronic stress. This study assessed impacts different durations CUMS on anxiety-like behavior, inflammation, and tryptophan metabolism in female C57BL/6N mice. The results revealed significant behavioral changes after 2-4 weeks CUMS. Specifically, open arms ratio time elevated plus maze (EPM)...
Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). miRNAs represent small regulatory RNA molecules that have been shown to act as negative regulators gene expression controlling different biological processes, including system homoeostasis function. We investigated cellular distribution miRNA-146a (miR-146a) a rat model TLE. Prominent up-regulation miR-146a activation was evident 1 week after status epilepticus (SE) persisted...
Blood-brain barrier (BBB) destruction is associated with a variety of neurological diseases. Brain microvascular endothelial cells (BMECs) are the key constituent BBB. Both matrix metalloproteinases-2/9 (MMP-2/9) and toll-like receptor-2 (TLR2) coexpressed in BMECs have been shown to play important roles BBB breakdown. It unknown whether TLR2 can regulate MMP-2/9 BMECs. In this study, Pam3CSK4 was used activate TLR2, expression tight junctions (TJs) measured by quantitative real-time PCR...
Abstract Urokinase‐type plasminogen activator receptor (uPAR) is a glycosyl phosphatidylinositol‐anchored protein involved in cell adhesion, proliferation, differentiation, migration, invasion, and tissue repair remodeling. Our aim was to investigate uPAR expression the frontal cortex of patients with intractable lobe epilepsy explore possible role epilepsy. Tissue samples were obtained from 25 who had undergone surgery for 15 histologically normal tissues orbital severe contusion (the...
The growth differentiation factor-15 (GDF-15) may be involved in atherosclerosis. However, the role of GDF-15 atherosclerosis remains unclear. main goal this study was to verify and mechanism atherogenesis. We first compared serum level between patients with coronary healthy people. And then one ApoE−/− mouse model used explore effects on oxidized low-density lipoprotein (oxLDL) accumulation, atherosclerosis-related gene expression, lipid accumulation-related protein expression macrophages....
We studied how tomato (Lycopersicon esculentum Mill.) chloroplast omega-3 fatty acid desaturase gene (Lefad7) overexpression enhanced low-temperature (LT) tolerance in transgenic plants. In these plants, the content of linolenic (18:3) markedly increased and, correspondingly, linoleic (18:2) decreased. Similar changes were found after 6 h under LT (4°C) treatment. Under stress, wild type (WT) plants showed a much greater increase relative electrolyte leakage and malondialdehyde (MDA)...
Molecular and stable carbon isotopic compositions of 32 crude oils from the Kekeya area Southwest Depression, Tarim Basin, were analyzed comprehensively to clarify oil groups trace sources. The results indicate that lacustrine shale sequences within Upper-Middle Permian Pusige Formation (P3–2p) are major effective sources; thermal maturation effects exert crucial impact on geochemical oils. In structural belt, produced Lower-Neogene, Middle-Paleogene Middle-Cretaceous sandstone reservoirs...
Movement disorders (MDs) are common in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis but poorly studied. This study aimed to investigate the clinical characteristics of MDs and differences between patients with without anti-NMDAR encephalitis.
Purpose: Basal lamina is a major part of the microvascular wall and plays critical role in integrity microvasculature. The aim this study to determine whether hyperthermia worsens destruction ischaemic injured brain.Materials methods: Focal cerebral ischaemia was induced by embolising pre-formed clot into middle artery (MCA). Rats received either normothermic or hyperthermic treatment. Neurological score infarct size were evaluated at 24 h after MCA occlusion. Microvascular collagen type IV...
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an antibody-related autoimmune encephalitis. It characterized by the existence of antibodies against NMDAR, mainly GluN1 subunit, in cerebrospinal fluid (CSF). Recent research suggests that anti-NMDAR may reduce NMDAR levels this disorder, compromising synaptic activity hippocampus. Although are used as diagnostic indicators, origin central nervous system (CNS) unclear. The blood-brain barrier (BBB), which separates brain from...
AMA Gao Y, Liu J, Wang X, Meng Q. Vanillin attenuates oxidative stress and neurochemical balance in MPTP-induced Parkinson’s disease mice by regulating the TLR-4 inflammatory pathway. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.131191. APA Gao, Y., Liu, J., Wang, X., & Meng, (2023). https://doi.org/10.5114/fn.2023.131191 Chicago Yuan, Jiang Xiaoyan Qiang Meng. "Vanillin pathway". Harvard MLA Yuan et al. pathway." Neuropathologica, Vancouver
Distinct brain regions are differentially affected during the various stages of Alzheimer's disease (AD). While hippocampus and cortex known to play significant roles, involvement cerebellum has received less attention. Understanding changes in diverse is essential unravel neuropathological mechanism early-stage AD. Our research aimed explore compare amyloid-β (Aβ) pathology gene expression profiles across hippocampus, cortex, early Amyloid Precursor Protein/Presenilin-1 (APP/PS1) mouse...
Changes in brain tissue stiffness are closely linked to the development and diseases of nervous system. Endoplasmic reticulum (ER) stress plays a role various pathological processes related epilepsy. However, relationship between changes, ER stress, epilepsy remains unclear. This study aimed investigate impact Best1 upregulation on alleviating underlying mechanism. Additionally, we proposed protective strategy prevent cell death resulting from investigated expression levels stress-related...
In the early stages of coronavirus disease 2019 (COVID-19) outbreak, most widely recognised symptoms were fever, cough, shortness breath, myalgia, and fatigue. However, in addition to these symptoms, COVID-19 can cause systemic outside lungs. Older patients with severe often require admission intensive care unit (ICU). Acute rectal ulcer bleeding, characterised by painless, profuse haematochezia, caused solitary or multiple ulcers, is one main causes haematochezia ICU. recurrent duodenal...