A5100328459- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Circadian rhythm and melatonin
- Infective Endocarditis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Cardiac and Coronary Surgery Techniques
- Anesthesia and Neurotoxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital heart defects research
- Eicosanoids and Hypertension Pharmacology
- Endoplasmic Reticulum Stress and Disease
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Coronary Artery Anomalies
- Aortic aneurysm repair treatments
- Electrospun Nanofibers in Biomedical Applications
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
Sansure Biotech (China)
2024
China Pharmaceutical University
2024
Chongqing Cancer Hospital
2024
Chongqing University
2024
Beijing General Research Institute of Mining and Metallurgy
2024
Nanjing Agricultural University
2024
Xijing Hospital
2014-2023
Air Force Medical University
2014-2023
East China University of Science and Technology
2023
Dalian University of Technology
2022-2023
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide-dependent histone deacetylases. Sirtuin-3 (SIRT3) is member the sirtuin that localized primarily to mitochondria and protects against oxidative stress-related diseases, including myocardial ischemia/reperfusion (MI/R) injury. Melatonin has favorable effect in ameliorating MI/R We hypothesized melatonin injury by activating SIRT3 signaling pathway. In this study, mice were pretreated with or without...
Ischemia/reperfusion injury (IRI) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. Numerous data indicate that JAK2/STAT3 signaling pathway specifically involved in preventing myocardial IRI. Melatonin has potent activity against IRI may regulate signaling. This study investigated protective effect of melatonin pretreatment on elucidated its potential mechanism. Perfused isolated rat hearts cultured neonatal cardiomyocytes were exposed absence or presence...
Abstract Enhancing mitochondrial biogenesis and reducing oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial ischemia/reperfusion (MI/R) injury. Melatonin has been reported be a safe potent cardioprotective agent. However, its role on or reactive oxygen species (ROS) production in type 1 myocardium the underlying mechanisms remain unknown. We hypothesize that melatonin ameliorates MI/R injury rats by preserving function via AMPK-PGC-1α-SIRT3...
Objective— Reduced plasma adiponectin (APN) in diabetic patients is associated with endothelial dysfunction. However, APN knockout animals manifest modest systemic dysfunction unless metabolically challenged. The protein family CTRPs (C1q/TNF-related proteins) has recently been identified as paralogs and some CTRP members share APN′s metabolic regulatory function. the vasoactive properties of remain completely unknown. Methods Results— vasoactivity currently murine was assessed aortic...
Abstract Melatonin confers cardioprotective effect against myocardial ischemia/reperfusion ( MI / R ) injury by reducing oxidative stress. Activation of silent information regulator 1 SIRT 1) signaling also reduces injury. We hypothesize that melatonin may protect activating signaling. This study investigated the protective treatment on heart and elucidated its potential mechanisms. Rats were exposed to in presence or absence receptor antagonist luzindole inhibitor EX 527 then subjected...
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective cardioprotective agent its strong antioxidative activity. However, roles and underlying mechanisms against MI/R injury in type 1 diabetes (T1D) remain unknown. Since SIRT1 Nrf2 are pivotal regulators mellitus patients suffering from injury, we hypothesized that HKL ameliorates via the SIRT1-Nrf2 signaling pathway....
No medical intervention has been identified that decreases acute kidney injury and improves renal outcome at 1 year after cardiac surgery.
Diabetes mellitus (DM) increases myocardial oxidative stress and endoplasmic reticulum (ER) stress. Melatonin confers cardioprotective effect by suppressing damage. However, the mechanism of melatonin on ischemia-reperfusion (MI/R) injury in type 2 diabetic state are still unknown. In this study, we developed high-fat diet-fed streptozotocin (HFD-STZ) rat, a well-known model, to evaluate MI/R with focus silent information regulator 1 (SIRT1) signaling, stress, PERK/eIF2α/ATF4-mediated ER...
Berberine (BBR) exerts potential protective effect against myocardial ischemia/reperfusion (MI/R) injury. Activation of silent information regulator 1 (SIRT1) signaling attenuates MI/R injury by reducing oxidative damage and inflammation response. This study investigated the antioxidative anti‐inflammatory effects BBR treatment in condition elucidated its mechanisms. Sprague‐Dawley rats were treated with absence or presence SIRT1 inhibitor sirtinol (Stnl) then subjected to conferred...
The objective of this study was to evaluate the safety and efficacy surgical versus transcatheter approach correct perimembranous ventricular septal defects (pmVSDs) in a prospective, randomized, controlled clinical trial.pmVSD is common congenital heart disease children. Surgical closure pmVSD well-established therapy but requires open-heart surgery with cardiopulmonary bypass. Although associated significant incidence complete atrioventricular block, it may provide less invasive...
Abstract Melatonin confers profound protective effect against myocardial ischemia–reperfusion injury ( MI / RI ). Activation of N otch1/ H airy and enhancer split 1 es1) signaling also ameliorates . We hypothesize that melatonin attenuates ‐induced oxidative damage by activating es1 pathway with phosphatase tensin homolog deleted on chromosome 10 P ten)/ A kt acting as the downstream in a membrane receptor‐dependent manner. Male S prague D awley rats were treated (10 mg/kg/day) for 4 wk then...
Acute myocardial dysfunction in patients with sepsis is attributed to oxidative stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are still lacking. Tetrahydrocurcumin (THC) has been proven contribute the of various cardiovascular diseases by decreasing stress inflammation. This study was performed investigate functions mechanism action THC septic cardiomyopathy.After oral administration (120 mg/kg) 5 consecutive days, a mouse model established via...
Dendrobium officinale polysaccharide (DOP), which serves as a prebiotic, exhibits variety of biological activities, including hypoglycemic activities. However, the effects DOP on diabetes prevention and its mechanisms are still unclear. In this study, treatment prediabetic mice model were studied mechanism was investigated. The results showed that 200 mg/kg/d reduced relative risk type 2 mellitus (T2DM) from prediabetes by 63.7%. Meanwhile, decreased level LPS inhibited expression TLR4...
AimsThe aim of this study was to evaluate the safety and efficacy transcatheter closure for perimembranous ventricular septal defect (pmVSD) its long-term results. The most common congenital heart condition is pmVSD. Transcatheter pmVSD a recently described technique with limited results mid- follow-up.
Previous studies have shown that the JAK2/STAT3 signaling pathway plays a regulatory role in cellular oxidative stress injury (OSI). In this study, we explored of hydrogen peroxide (H2O2)-induced OSI and protective effect melatonin against human umbilical vein endothelial cells (HUVECs). AG490 (a specific inhibitor pathway) JAK2 siRNA were used to manipulate activity, results showed inhibited levels p-JAK2 p-STAT3. HUVECs then subjected H2O2 absence or presence melatonin, main secretory...