A5100357785- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Fluoride Effects and Removal
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Chronic Kidney Disease and Diabetes
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Flavonoids in Medical Research
- Diabetes and associated disorders
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Hepatitis C virus research
- Airway Management and Intubation Techniques
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Folate and B Vitamins Research
- Pancreatic function and diabetes
- RNA modifications and cancer
Northwest A&F University
2021-2025
Analysis Group (United States)
2025
Jiangsu University
2025
META Group
2025
Guangzhou Sport University
2024
Sichuan University
2011-2024
West China Hospital of Sichuan University
2014-2024
Suzhou Guangji Hospital
2024
Soochow University
2024
Liverpool School of Tropical Medicine
2024
Mycobacterium tuberculosis is a hard-to-eradicate intracellular pathogen that infects one-third of the global population. It can live within macrophages owning to its ability arrest phagolysosome biogenesis. Autophagy has recently been identified as an effective way control mycobacteria by enhancing phagosome maturation. In present study, we demonstrate novel role miR-155 in regulating autophagy-mediated anti-mycobacterial response. Both vivo and vitro studies showed expression was...
Diabetic kidney disease (DKD) occurs in ∼40% of patients with diabetes and causes failure, cardiovascular disease, premature death. We analyzed the response a murine DKD model to five treatment regimens using single-cell RNA sequencing (scRNA-seq). Our atlas ∼1 million cells revealed heterogeneous all cell types both its treatment. Both monotherapy combination therapies targeted differing induced distinct non-overlapping transcriptional changes. The early effects sodium-glucose...
No medical intervention has been identified that decreases acute kidney injury and improves renal outcome at 1 year after cardiac surgery.
In China during March 4-April 28, 2013, avian influenza A(H7N9) virus testing was performed on 20,739 specimens from patients with influenza-like illness in 10 provinces confirmed human cases: 6 (0.03%) were positive, and increased numbers of unsubtypeable influenza-positive not seen. Careful monitoring rapid characterization other viruses remain critical.
Awake prone positioning has been reported to reduce endotracheal intubation in patients with coronavirus disease 2019 (COVID-19)-related acute hypoxemic respiratory failure (AHRF). However, it is still unclear whether using the awake for longer periods can further improve outcomes.
The purpose of present study was to examine the current prevalence and recent trends overactive bladder (OAB) among US adult men correlations between OAB several potential risk factors. used nationally representative data 2005 2020 from National Health Nutrition Examination Survey in US. A total 18,386 participants aged ≥ 20 years were included study. We divided into three groups: 2005-2008, 2009-2014 2015-2020 investigate prevalence. weighted corresponding 95% confidence intervals (CI)...
Tongkat Ali (Eurycoma longifolia; TA) is known to increase testosterone levels and alleviate aging males' symptoms. This study aimed at investigating TA as an ergogenic supplement for elderly people. Thirteen physically active male 12 female seniors (57-72 years) were supplemented with 400-mg extract daily 5 weeks. Standard hematological parameters taken. In addition, the concentrations of total free testosterone, dihydroepiandrosterone, cortisol, insulin-like growth factor-1, sex...
Nonalcoholic fatty liver disease (NAFLD) is characterized by marked imbalances in lipid storage and metabolism. Because the beneficial health effects of cereal β-glucan (BG) include lowering cholesterol regulating metabolism, BG may alleviate metabolism observed during NAFLD. The aim our study was to investigate whether from highland barley has an effect on western diet-induced NAFLD mice. Using lipidomics, we investigated underlying mechanisms intervention, identified potential biomarkers....
SUMMARY Citric acid in plant cells is crucial for growth as it serves a precursor to multiple essential compounds. It also helps plants tolerate high temperatures. However, the mechanisms remain unclear regarding how citric balances its role promoting and protecting against stress. We identified an ACLA protein, subunit of ATP citrate lyase (ACL) pepper ( Capsicum annuum ), that converts cytosolic into acetyl‐CoA. Silencing reduced metabolites, leading stunted decreased heat tolerance....
Acute kidney failure and chronic disease are global health issues steadily rising in incidence prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we used simple model folic acid–induced injury 7 highly diverse mouse strains. We measured plasma urine parameters, as well renal histopathology mRNA expression data, at 1, 2, 6 weeks after injury, covering early recovery long-term remission. observed...
This study investigated factors considered as having an influence on the psychological adaptation of college students. Some 1,134 students from Wu Han University, Hui Bei province, China, participated in with impressive response rate 99%. Results indicate that such “parental occupations”, education”, “interest major”, “body image”, “place raised” and “gender” have a significant correlation China. Asignificant relationship was found between fathers' education occupation students' levels...
Osteosarcoma is a primary malignancy of mesenchymal origin, and its metastasis multidrug resistance remain major problems affecting the therapeutic effect. This study aimed to evaluate efficacy underlying mechanism monoacylglycerol lipase (MAGL) on osteosarcoma progression. MAGL expression was downregulated by shMAGL or JZL184 (an inhibitor) upregulated through plasmid. RT-PCR Western blot were utilized determine target molecules. CCK-8 assay, transwell assay ROS performed investigate...
The World Health Organization Quality of Life-100 (WHOQOL-100, Power, Harper, Bullinger, & WHO1QLG), the Self-Rating Anxiety Scale (Zhang, 1993), and Depression 1993) were used to determine whether Chinese college students from only child sibling families rated perceptions their quality life differently. Small moderate significant differences found when comparing on WHOQOL-100 with no measures anxiety depression. These results suggest that do not differ greatly in terms overall life. A...
The prevalence of obesity is dramatic increased and strongly associated with cardiovascular disease. Adipokines, secreted from adipose tissues, are critical risk factors for the development cardiomyopathy. Present study aimed to investigate pathophysiological role autotaxin in obesity-related In high-fat diet-fed mice, was mainly synthesized adipocytes. accumulation cardiac positively dysfunction obese mice. Interestingly, specific blockage tissue effectively protected against diet-induced...
E3 ubiquitin ligase gene, WWP2 , is associated with acute kidney injury ( AKI ). This research was conducted to explore the role of in . cell model produced human renal proximal tubular epithelial line HK ‐2) by ischemia‐reperfusion IR ) injury. CCK8 and flow cytometry assay were performed influence overexpression on proliferation apoptosis ‐induced ‐2 cells. Quantitative real‐time PCR immunoblotting (IB) assess gene protein expression. Then, p53 ubiquitylation degradation estimated...
Short-chain fatty acids (SCFAs) in feces are inextricably linked to intestinal homeostasis and can be used as potential markers for metabolic diseases. In this study, an efficient simple method was developed the purification of SCFAs without need derivatization samples. The (acetic, propionic, isobutyric, butyric, isovaleric, valeric, hexanoic acid) were extracted from a small amount (50 mg) fecal samples using acetone combined with solid phase extraction column (Bond Elut Plexa) enrichment....
Henoch-Schönlein purpura (HSP) is an immune complex-mediated disease predominantly characterized by the deposition of circulating complexes containing immunoglobulin A (IgA) on walls small vessels. Although pathogenesis HSP not yet fully understood, some researchers proposed that B-cell activation might play a critical role in development this disease.To investigate serum levels visfatin (pre-B-cell colony-enhancing factor), B-cell-activating factor (BAFF), and CXCL13, to analyze their...