A5100378247- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health disparities and outcomes
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Hepatitis B Virus Studies
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Cardiac Health and Mental Health
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Vaccine Coverage and Hesitancy
- Eosinophilic Disorders and Syndromes
- COVID-19 epidemiological studies
- Cancer Genomics and Diagnostics
- Viral Infections and Vectors
- Traditional Chinese Medicine Analysis
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
Lanzhou University
2016-2025
First Hospital of Lanzhou University
2016-2025
Xi'an Medical University
2018-2024
Renji Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
National Clinical Research Center for Digestive Diseases
2019-2024
Peking University
2019-2024
The Ohio State University
2021-2024
The Ohio State University Wexner Medical Center
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
China, which has the largest chronic hepatitis B virus (HBV) burden, may expand antiviral therapy to attain World Health Organization (WHO)-2030 goal of 65% reduction in mortality. We evaluated health outcomes and cost-effectiveness HBV infection treatments based on alanine transaminase (ALT) treatment initiation thresholds coverage China identify an optimal strategy. A decision-tree Markov state-transition model expanded for by simulating 136 scenarios ALT (40 U/L, 35 U/L males 25 females,...
Atherogenic index of plasma (AIP) at baseline has been associated with increased morbidity and mortality from cardiovascular disease (CVD). However, the relationship between long-term AIP trajectories CVD remains unclear. Therefore, this study aimed to investigate associations incidence in English population. The data analysis was based on Longitudinal Study Aging (ELSA) 2004 2017. population consisted individuals aged 50 years older England. calculated as log10 (triglycerides/high-density...
To test the feasibility, safety, immunogenicity, and clinical efficacy of an autologous vaccine leukocyte-derived heat shock protein 70-peptide complexes (Hsp70PC), in conjunction with imatinib mesylate, patients chronic myeloid leukemia (CML) phase.Patients had cytogenetic or molecular evidence disease, despite treatment mesylate for all except one patient, at beginning study. Hsp70PCs were purified from leukopheresed peripheral blood mononuclear cells administered eight weekly intradermal...
We examined if transplantation of combined haploidentical hematopoietic stem cells (HSC) and mesenchymal (MSC) affected graft failure graft-versus-host disease (GVHD) in patients with severe aplastic anemia (SAA). Patients SAA-I (N = 17) received HSCT plus MSC infusion. Stem cell grafts used a combination granulocyte colony-stimulating factor (G-CSF)-primed bone marrow G-CSF-mobilized peripheral blood donors the culture-expanded third-party donor-derived umbilical cord MSCs (UC-MSCs),...
Chemotherapy failure remains a challenge when treating patients with acute myeloid leukemia (AML), who often suffer from persistent or relapsed disease. The multidrug resistance (MDR) mediated by efflux transporters of the ATP binding cassette (ABC) superfamily is major obstacle for successful chemotherapy. present study aimed to elucidate whether expression ABC was associated prognostic factors and responses chemotherapy in AML, particular focus on co-expression multiple resulted worse...
Abstract Background The aim of the current study is to assess cross-sectional association chronic non-communicable diseases (hypertension, diabetes mellitus, arthritis, and cerebrovascular) with depressive symptoms among older adults in China. Methods Data was obtained from China Longitudinal Ageing Social Survey (CLASS) conducted 2014. A total 7505 participants were included. Depressive status assessed by 9-item Center for Epidemiological Studies Depression Scale (CES-D) Associations...
This study investigated whether the neddylation inhibitor MLN4924 induces aberrant DNA methylation patterns in acute myeloid leukemia and contributes to reactivation of tumor suppressor genes. profiles Kasumi-1 KU812 cell lines before after treatment were generated using 850K Methylation BeadChip. RNA sequencing was used obtain transcriptomic cells. Target genes identified through a combined analysis transcriptome data. Methylation-specific PCR quantitative validated changes expression....
The purpose of this study was to identify whether the gut microbiota and metabolites newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations these changes could be used as potential biomarkers for predicting disease. Notably, AML exhibited significant structural quantitative at time their initial diagnosis. Beneficial bacteria, including Faecalibacterium, Collinsella, Lacticaseibacillus, Roseburia, well butyric acid acetic acid, were found...
Background: To investigate the prevalence of burnout syndrome among Chinese female nurses during controlled coronavirus disease 2019 (COVID-19) period and explore its associated socio-demographic factors job characteristics. Methods: With multistage, stratified sampling method, a cross-sectional online survey was conducted from September to October 2020 in China. The tool included revised Maslach Burnout Inventory (MBI) with 15 items, Univariate logistic regression analysis multivariate...
To investigate the role of vascular endothelial growth factor (VEGF) in increased permeability cells after Hantaan virus (HTNV) infection humans, concentration VEGF serum from HTNV infected patients was quantified with sandwich ELISA. Generally, level elevated to 607.0 (542.2–671.9) pg/mL, which dramatically higher compared healthy controls (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Histone deacetylase inhibitors (HDACIs) are a promising class of drugs that act as antiproliferative agents by promoting differentiation and inducing apoptosis. Valproic acid (VPA) is an HDACI has been widely used anti-convulsant shows promise chemotherapeutic drug for number tumor cells. The present study aimed to investigate the inhibitory effect VPA on viability bladder cancer cells its synergistic with in vitro vivo. cell human lines following treatment and/or combination mitomycin C,...
Purpose:We aimed to test whether α-internexin could be a molecular biomarker of tumor aggressiveness and prognosis in pancreatic neuroendocrine tumors (PNETs).
BackgroundHantaan virus (HTNV) could cause a severe lethal hemorrhagic fever with renal syndrome (HFRS) in humans. Despite limited understanding of the pathogenesis HFRS, importance host-related immune responses HFRS has been widely recognized. CD100/Sema4D demonstrated to play an important role physiological and pathological responses, but functional CD100 infectious diseases only inadequately reported. The aim this study was investigate significance patients after HTNV infection....
Body Mass Index (BMI) is a risk indicator for some eye diseases. However, the association between BMI and Visual Impairment (VI) was not quite certain in Chinese students. Our aim to assess relationship VI with cross-sectional study. A total of 3771 students aged 6-21 years, including 729 VI, were sampled from 24 schools Huangpi District central China participate multistage stratified cluster random sampling adopted. Each answered questionnaire had physical examinations. The examined...
Abstract Goji berry tea, a traditional herbal is the main ate mode of goji in Asia, yet few studies comparison with red tea and black are carried out. This study investigated effects water temperature soak time on colour, phytochemicals, antioxidant capacity [2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), ferric-reducing power (FRAP)] two tea. A bioactive compounds activities between was conducted. Results showed that both were...
Although some studies have reported the association between life negative events and depressive disorders, very limited examined exposure symptoms risk among Chinese older adults.Data were obtained from China Longitudinal Ageing Social Survey (CLASS), which was a stratified, multi-stage, probabilistic sampling survey, conducted in 2014. General linear regression logistic used to examine adults.Life showed statistical dose-response with after adjustment for confounding factors (Ptrend <...