A5102825524- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Nanowire Synthesis and Applications
- Tissue Engineering and Regenerative Medicine
- ZnO doping and properties
- Carbon Nanotubes in Composites
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine regulation and behavior
- Semiconductor materials and devices
- Acute Myeloid Leukemia Research
- Electrospun Nanofibers in Biomedical Applications
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Clinical Nutrition and Gastroenterology
- Organ and Tissue Transplantation Research
- Liver Disease and Transplantation
- Cerebrovascular and Carotid Artery Diseases
- Hormonal Regulation and Hypertension
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Advancements in Semiconductor Devices and Circuit Design
- Dysphagia Assessment and Management
- Traumatic Brain Injury Research
- Acute Ischemic Stroke Management
First Hospital of Lanzhou University
2018-2025
Shandong Eye Hospital
2021-2025
Shandong First Medical University
2019-2025
Northeastern University
2025
Lanzhou University
2018-2025
University of Science and Technology of China
2025
National Synchrotron Radiation Laboratory
2025
Sichuan University
2021-2025
West China Hospital of Sichuan University
2021-2025
Hebei Medical University
2019-2024
The extracellular domain of the (pro)renin receptor (PRR) is cleaved to produce a soluble (sPRR) that detected in biological fluid and elevated under certain pathological conditions. present study was performed define antidiuretic action sPRR its potential interaction with liver X receptors (LXRs), which are known regulators urine-concentrating capability. Water deprivation consistently urinary excretion mice humans. A template-based algorithm for protein-protein predicted between frizzled-8...
Hydrogels have attracted tremendous attention as favorable corneal substitutes for treating severe infectious keratitis (IK). However, current hydrogel-based were majorly designed to promote the single stage of regeneration, which falls short in meeting clinical management needs IK including multiple phases wound healing. Herein, we introduce a versatile hybrid hydrogel (SQPV) composed silk fibroin and chitosan, exhibits spatiotemporal properties drug release. The SQPV is fabricated by...
Zinc oxide (ZnO) nanowires are prepared for application in large area gated field emitter arrays (FEAs). By oxidizing Al-coated Zn films, the population density of ZnO was tuned precisely by varying thickness Al film. The nanowire decreased linearly as film increased. Optimal emission properties with a turn-on 6.21 V μm-1 and current fluctuations less than 1% obtained. This can be explained minimized screening effect good electrical conductivity back-contact layer. mechanism responsible...
We aimed to compare the clinical effectiveness of combination therapy transarterial chemoembolization (TACE) and microwave ablation (MWA) with TACE monotherapy in BCLC stage B HCC patients tumor size ≤7 cm number ≤5.We retrospectively reviewed 150 who had received or TACE-MWA our hospital from March 2007 April 2016. The were matched by propensity score at ratio 1:2 optimal method. median follow-up period was 16 months. overall survival, response progression-free survival compared between two...
The repair of large-diameter corneal stroma defects is a major clinical problem. Although some studies have attempted to use hydrogels damage, most these can only be used for focal stromal that are ≤3.5 mm in diameter due poor hydrogel adhesion. Here, photocurable adhesive mimics the extracellular matrix (ECM) with regard composition repairing 6 mm-diameter rabbits investigated. This ECM-like rapidly cured after light exposure, high transmittance and good mechanical properties. More...
Abstract Decellularization can reduce the immune barrier of xenotransplantation, but tissue swelling‐caused structural and functional damage remains unsolved, including corneal transparency loss after decellularization. Here, a protective decellularization strategy is developed for preparation decellularized porcine cornea (DPC), in which corneas are treated by detergent endonuclease medium with 50 mmHg colloid osmotic pressure. A nonrandomized open‐label trial conducted to evaluate clinical...
Abstract Corneal injectable hydrogels represent a promising alternative to alleviate donor shortage and simplify traditional surgeries. However, most focus on repairing focal corneal defects (≤3.5 mm) leave many clinical requirements unmet. Herein, novel ion‐activated bioadhesive hydrogel (IonBAH) is designed its long‐term performance of large (6 evaluated in rabbits for 6 months. The IonBAH dual‐network composed natural extracellular matrix peptide‐modified alginate, which enables desirable...
This study investigated whether the neddylation inhibitor MLN4924 induces aberrant DNA methylation patterns in acute myeloid leukemia and contributes to reactivation of tumor suppressor genes. profiles Kasumi-1 KU812 cell lines before after treatment were generated using 850K Methylation BeadChip. RNA sequencing was used obtain transcriptomic cells. Target genes identified through a combined analysis transcriptome data. Methylation-specific PCR quantitative validated changes expression....
Abstract Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization corneal stroma is challenging. In this study, humanized stroma‐like adhesive patches (HCSPs) are prepared through a multi‐step process. First, polyethylene glycol diacrylate cast cured within decellularized porcine cornea (DPC) templates. The DPCs then enzymatically digested to...
Injectable recombinant collagen hydrogels (RCHs) are crucial in biomedical applications. Culture conditions play an important role the preparation of hydrogels. However, determining characteristics under certain and optimal swiftly still remain challenging tasks. In this study, a machine learning approach was introduced to explore correlation between hydrogel culture determine conditions. The study focused on four key factors as independent variables: initial substrate concentration,...
Tracking and eradicating drug-resistant bacteria are critical for combating implant-associated infections, yet effective antibacterial therapies remain elusive. Herein, we propose an oxygen vacancy–rich (BiFe) 0.9 (BaTi) 0.1 O 3− x nanoreactor as a piezoelectric sonosensitizer by spatiotemporal ultrasound–driven sono- chemodynamic tandem catalysis to amplify efficacy. The charge carriers under built-in electric field synchronize the reaction of 2 H O, efficiently generating . electron-rich...
Corneal decellularization represents a promising alternative source of human donor with global shortage. Multiple methods have been developed for the preparation decellularized porcine corneal stroma. However, most strategies relied on long-time treatment to facilitate entry detergents or nucleases, which may cause irreversible ultrastructural damage. Here, we rapid method stroma through combined mild detergent sodium N-lauroyl glutamate (SLG) and supernuclease. Compared traditional methods,...
The antidiuretic hormone vasopressin (AVP), acting through its type 2 receptor (V2R) in the collecting duct (CD), critically controls urine concentrating capability. Here, we report that site-1 protease–derived (S1P-derived) soluble (pro)renin (sPRR) participates regulation of fluid homeostasis via targeting V2R. In cultured inner medullary (IMCD) cells, AVP-induced V2R expression was blunted by a PRR antagonist, PRO20; PRR-neutralizing antibody; or S1P inhibitor, PF-429242. parallel, sPRR...
Intracerebral hemorrhage (ICH) is a devastating event with high disability and fatality rates. However, there lack of effective treatments for this condition. We aimed to investigate the neuroprotective axonal regenerative effects progesterone after ICH. For purpose, an ICH model was established in adult mice by injecting type VII collagenase into striatum; were then treated (8 mg/kg). Hematoma absorption, neurological scores, brain water content evaluated on days one, three, seven The...