A5115590913- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Epilepsy research and treatment
- Cancer-related molecular mechanisms research
- Graphene and Nanomaterials Applications
- Magnetic Properties and Applications
- Corneal Surgery and Treatments
- Circular RNAs in diseases
- Pharmacological Effects and Toxicity Studies
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Sphingolipid Metabolism and Signaling
- Advanced MEMS and NEMS Technologies
- Ultrasound and Hyperthermia Applications
- Environmental remediation with nanomaterials
- Bioactive Compounds and Antitumor Agents
- Induction Heating and Inverter Technology
- Cancer Mechanisms and Therapy
- Advanced Photocatalysis Techniques
- E-commerce and Technology Innovations
- Lysosomal Storage Disorders Research
- Extracellular vesicles in disease
Sichuan University
2017-2025
West China Hospital of Sichuan University
2024-2025
Southwest Forestry University
2024
Shenzhen Technology University
2024
Nanjing Normal University
2024
Huzhou University
2024
Chinese Academy of Sciences
2023
Aerospace Information Research Institute
2023
University of Chinese Academy of Sciences
2023
State Key Laboratory of Transducer Technology
2023
MicroRNA (miR)-145 has been reported to induce cancer stem cell (CSC) differentiation through down-regulation of the transcription factors (TFs) that maintain CSC pluripotency. High expression miR-145 indicates a good prognosis in patients, but its role cervical cells (CCSCs) is not known. We show and core factors, Sox2, Nanog Oct4, are associated with pluripotency CCSCs, increased after tumorsphere (CT) differentiation. overexpression inhibited TFs, as well decreasing tumor invasion colony...
Tracking and eradicating drug-resistant bacteria are critical for combating implant-associated infections, yet effective antibacterial therapies remain elusive. Herein, we propose an oxygen vacancy–rich (BiFe) 0.9 (BaTi) 0.1 O 3− x nanoreactor as a piezoelectric sonosensitizer by spatiotemporal ultrasound–driven sono- chemodynamic tandem catalysis to amplify efficacy. The charge carriers under built-in electric field synchronize the reaction of 2 H O, efficiently generating . electron-rich...
Plumbagin is a natural naphthoquinone constituent isolated from the roots of medicinal plant Plumbago zeylanica L., and has demonstrated anti-proliferative anti-invasion activities in various cancer cells. However, its effect on migration invasion glioma cells not been elucidated. Therefore, human U87 U251 were treated with plumbagin at 1.0 2.0 μM for 24 h, cell assessed scratch wound healing assays. The results showed that significantly inhibited cells, suppressed activity expression...
Objective: The aim of this paper was to retrospectively compare the therapeutic efficacy and adverse effects ultrasound-guided high-intensity focused ultrasound (USgHIFU) treatment for adenomyotic patients with or without prior abdominal surgical scars. Methods: From January 2011 March 2014, 534 adenomyosis were referred HIFU treatment. Among them, 118 had scars, 416 did not have Contrast-enhanced MRI used evaluate outcomes. All recorded. Results: completed USgHIFU A fractional ablation 74.8...
Abstract Using magnetomechanical force to kill cancer cells has attracted great attention recently. This study presents novel hedgehog‐like microspheres composed of needle‐like magnetic nanoparticles with carbon and gold double shells. a low‐frequency vibrating field (VMF), these sharp surfaces can seriously damage strongly inhibit mouse tumor growth through mechanical force. The cell killing efficiency depends on VMF exposure time, frequency, strength, microsphere concentration. maximum...
Insufficient proliferation, differentiation, and migration are the main pitfalls of neural stem cells (NSCs) in reparative therapeutics for central nervous system (CNS) diseases. The potent lipid mediator sphingosine-1-phosphate (S1P) regulates cells' biological behavior broadly CNS. However, effects activating S1P on NSCs not quite clear. In current study, FTY720 (Fingolimod), an analog S1P, was employed to induce cultured brain-derived NSCs. results indicated that proliferation ability...
The epithelial–mesenchymal transition is the key process driving cancer metastasis. MicroRNA-194 inhibits in several cancers and its downregulation indicates a poor prognosis human endometrial carcinoma. Self-renewal factor Sox3 induces at gastrulation also involved cancers. We intended to determine roles of inducing stem cells possible role microRNA-194 controlling expression. Firstly, we found that expressions were associated with status panel carcinoma tissue, CD133+ cell was higher...
The memory dysfunction is one of the disastrous outcomes for perinatal hypoxia ischemia. Erythropoietin (EPO) has been demonstrated as a neuroprotective agent with multiple effects in series neurological diseases. We hypothesized that disruption neural network including synapses and neurites would contribute to induced by aim present study was elucidate involvement EPO on synaptogenesis neurite repair following Using neonatal ischemia rat model, we found rescued ischemia-induced decrease...
A 63-year-old man developed reduced consciousness and dysphagia progressively. Examination parameters were normal, except for a Glasgow Coma Scale score of seven, his grading on the swallow water test increased from grade 1 to 5. Brain imaging blood tests unexplainable by high plasma ammonia. His past medical history included cerebral infarction, hypertension epilepsy induced hyperperfusion syndrome. He was rceiving antiepileptic treatment continuously intravenously pumped sodium valproate...
Paphiopedilum micranthum, an IUCN Red List species, is discontinuously distributed in the karst limestone mountain of southwest China and exhibits ecological specialization, typically through lithophytic terrestrial ecotypes. Whether distribution rhizosphere bacteria fungi these different habitats random or reflects soil preferences requires further investigation. A total 73 samples from core areas China, representing all two sites, were analyzed for differences by comparing edaphic...
Graphitic carbon nanocages (GCNCs) have unique geometric structures and physical properties, which been extensively investigated for various applications. However, no reports focusing on using GCNCs polymer-coated solid tumor ablation induced by near-infrared laser irradiation under enhanced initial body temperature, or the biosafety of in vivo, published. Here, we developed chitosan (CS)-coated showed that both GCNCs/CS mouse tumors can rapidly convert an 808 nm light energy into heat,...
The high demand for advanced acoustic sensors has prompted optical microphones to become a current research hotspot; this is especially the case in light of performance existing electroacoustic having reached ceiling. In work, thermally stable microphone been developed sensitive detection low-frequency signals. was prepared using prestressed nickel diaphragm and compact grating interferometric module. adjacent surfaces form short Fabry-Perot cavity, which makes robust ambient temperature...
ABSTRACT Background Preterm white matter injury (PWMI) is the most common type of brain in preterm infants, which, oligodendrocyte progenitor cells (OPCs) are predominantly damaged. In this study, human OPCs (hOPCs) were administered to a fetal goat model PWMI examine differentiation potential and therapeutic effects on PWMI. Methods fetuses subjected hypoxic‐ischemia (HI) via intermittent umbilical cord occlusion (5 min × 5). Twenty million hOPCs nasal catheter 12 h after an HI insult,...
In order to improve the temperature uniformity of large wall thickness workpieces in heat treatment furnaces, a well type muffle free furnace with an inner diameter 2300 mm was designed. Forced convection transfer achieved by fan and guide tube, transient numerical simulation flow field during heating process carried out. A comparative analysis conducted on effects three different tube base structures rate treated workpieces. The results show that using optimized seven holes structure six...
Winding inductance always plays a key role in the electromagnetic performances of stator surface-mounted permanent magnet (SSPM) machines, including their flux-weakening capability, prospective fault current, power factor, current ripple, etc. Generally speaking, winding mainly comprises three components: an air-gap component, slot-leakage and end-leakage component. In this paper, firstly, pole pairs SSPM machines are investigated based on magneto-motive force-permeance model, through which...