A5002255955- Neonatal and fetal brain pathology
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Infant Nutrition and Health
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Retinopathy of Prematurity Studies
- Mesenchymal stem cell research
- Cancer-related gene regulation
- S100 Proteins and Annexins
- Preterm Birth and Chorioamnionitis
- Tuberculosis Research and Epidemiology
- Birth, Development, and Health
- Cell death mechanisms and regulation
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
Sichuan University
2016-2025
Nantong University
2024-2025
Huazhong University of Science and Technology
2022-2025
Tongji Hospital
2022-2025
Liaoning University of Traditional Chinese Medicine
2016-2025
Hospital of Hebei Province
2021-2024
State Key Laboratory of Oral Diseases
2019-2024
Shanghai Sunshine Rehabilitation Center
2024
Anhui University
2023-2024
Ministry of Education of the People's Republic of China
2022-2024
Abstract Enabling n→π* electronic transition in graphitic carbon nitride (g‐CN) can significantly enhance its photocatalytic performance by extending visible light absorption. However, achieving this remains a grand challenge due to the selection rule that restricts it planar tri‐s‐triazine units of g‐CN. Here, an effective strategy induce g‐CN nanosheets coupling infrared irradiation with lattice vibrations is presented. Theoretical simulations reveal two prominent vibration modes...
Early-life human gut microbiome is a pivotal driver of homeostasis and infant health. However, the viral component (known as "virome") remains mostly unexplored. Here, we establish Early-Life Gut Virome (ELGV), catalog 160,478 non-redundant DNA RNA sequences from 8130 virus-like particles (VLPs) enriched or bulk metagenomes in first three years life. By clustering, 82,141 species are identified, 68.3% which absent existing databases built mainly adults, 64 8 based on VLPs-enriched...
Abstract Background Sepsis is a critical disease associated with extremely high mortality. Some severe forms of sepsis can induce brain injury, thus causing behavioral and cognitive dysfunction. Pyroptosis type cell death that differs from apoptosis plays an important role in the occurrence development infectious diseases, nervous system-related diseases. A recent study has found there pyroptosis hippocampus sepsis-induced but its mechanism treatment scheme have not been evaluated. Methods...
Neuronal apoptosis is one of the main pathological processes hypoxic-ischemic brain damage (HIBD) and involved in development encephalopathy (HIE) neonates. Atorvastatin has been found to have neuroprotective effects some nervous system diseases, but its role regulating pathogenesis neonatal HIBD remains elusive. Thus, this study aimed explore related mechanisms atorvastatin on regulation neuronal after newborn rats. The rat model oxygen glucose deprivation (OGD) were established routinely....
Colorectal cancer (CRC) is a common and deadly disease of the digestive system, but its targeted therapy hampered by lack reliable specific biomarkers. Hence, discovering new therapeutic targets agents for CRC an urgent challenging task. Here we report that carnitine palmitoyltransferase 1A (CPT1A), mitochondrial enzyme catalyzes fatty acid oxidation (FAO), potential target treatment. We show CPT1A overexpressed in cells inhibition secolignan-type compound, 2,6-dihydroxypeperomin B (DHP-B),...
The proapoptotic function of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) has been linked to its capacity antagonize the phosphatidylinositol-3-kinase–Akt signaling pathway. Previous studies have shown that Forkhead transcriptional factor (FOXO3a) is a critical effector PTEN-mediated tumor suppressor. However, whether PTEN–Akt–FOXO3a pathway involved in neuronal apoptosis developing rat brain after hypoxia–ischemia (HI) unclear. In this study, we generated an HI model using...