A5100746076- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cancer Treatment and Pharmacology
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Immune cells in cancer
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Cardiac Fibrosis and Remodeling
- Glycosylation and Glycoproteins Research
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Natural product bioactivities and synthesis
- Antibiotics Pharmacokinetics and Efficacy
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
Sichuan University
2019-2025
West China Second University Hospital of Sichuan University
2019-2025
Nanjing University of Chinese Medicine
2015-2025
Fourth Hospital of Hebei Medical University
2023-2025
Guangxi Medical University
2024
Ludong University
2023-2024
Xiangya Hospital Central South University
2024
Central South University
2006-2024
State Key Laboratory of Food Science and Technology
2023
Hebei Medical University
2023
Abstract Background Sepsis is a critical disease associated with extremely high mortality. Some severe forms of sepsis can induce brain injury, thus causing behavioral and cognitive dysfunction. Pyroptosis type cell death that differs from apoptosis plays an important role in the occurrence development infectious diseases, nervous system-related diseases. A recent study has found there pyroptosis hippocampus sepsis-induced but its mechanism treatment scheme have not been evaluated. Methods...
Background: protein glycosylation varies with the physiological and pathological status of cell. Consequently, analysis protein-linked glycans has growing importance both in basic glycobiological research as a potential tool for monitoring state humans. Design, setting participants: total 265 healthy northern Chinese men women were grouped by age gender. The mean males females was similar. Objective: study is aimed to evaluate effects gender on human serum N-glycans profiles clinical...
Background The emergence of HER2 antibody-drug conjugates provides new treatment decisions for breast cancer patients, especially those with HER2-low expression. In order to explore the biological characteristics expression, category in primary and residual tumor after neoadjuvant therapy was investigated reflect evolution Methods assessed according latest ASCO/CAP guidelines. cut-off value staining HER2-positive cells >10%. HER2-negative cases were divided into (IHC=1+/2+ no ISH...
Abstract Objective With the emergence of new antibody coupled drugs, treatment decisions patients with low and ultra-low HER2 expression have been reshaped. However, epidemiological characteristics relatively rare male breast cancer are still unclear. This study discusses clinicopathological immunophenotypic invasive expression. Methods The features 106 cases were retrospectively analyzed. was evaluated according to ASCO/CAP guidelines. cutoff value positive cell staining > 10%. negative...
Both the roots and leaves of American ginseng contain ginsenosides polyphenols. The impact thermal processing on enhancing biological activities root by altering its component composition has been widely reported. However, effects far-infrared irradiation (FIR), an efficient heat treatment method, bioactive components remain to be elucidated. In present study, we investigated FIR between 160 200 °C deglycosylation dehydration rates in leaves. As temperature was increased, amounts common...
Sepsis-associated encephalopathy (SAE) is a common complication of severe sepsis. Some studies have suggested that P2X7 receptors, ligand-gated ion channel receptor subgroup activated by extracellular ATP, plays an important role in cell pyroptosis. However, the receptors development SAE with pyroptosis and its pathways are still unclear. In this study, we established juvenile rat model sepsis cecal ligation perforation, showed there was significant increase expression cortex rats When...
Chronic lymphocytic leukemia (CLL) is infrequent in Chinese people. Conventional cytogenetic analysis underestimates the frequency of chromosome aberrations CLL due to low rate spontaneous mitoses. The aim this study was prospectively explore chromosomal abnormalities patients with using interphase fluorescence situ hybridisation (FISH) and probes for 12 centromere, 13q14, 14q32, 17p13, 11q22 6q23 on 143 CLL. Molecular were found 104 (72.7%) 40 (28.0%) more than two abnormalities. most...
Burkitt lymphoma is a fast growing non-Hodgkin that occurs primarily in young males. The causes of include chromosome rearrangement and virus infection, but accurate complete reasons remain to be discovered. available treatment for chemotherapy radiation therapy. It highly aggressive B-cell neoplasm with not all patients cured, spite current therapies. This study evaluated the effects traditional Chinese medicine Marsdenia tenacssima (MTE) its component compound Tenacigenoside A (TGTA)...
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by sepsis. Pyroptosis and autophagy are important mechanisms in the pathogenesis of sepsis, also pannexin-1 involved occurrence However, role SAE its relationship with pyroptosis unclear. This study examined between pyroptosis, further explore mice.A mouse model was established cecal ligation puncture (CLP). Different groups mice were administrated probenecid (PRB), 3-methyladenine (3-MA), or vehicle control...
Sepsis has a high in clinic neonatal mortality. Moreover, considerable number of children's brains remain affected even after the treatment sepsis and it often leaves sequelae. Therefore, early intervention for is significance. Recent studies have shown that Club cell protein (CC16) closely related to p38 mitogen-activated kinase (MAPK) signaling pathway, which can regulate inflammation, oxidative stress, apoptosis, autophagy during sepsis. Thus, we analyzed neuroprotective effect...
Myocardial fibrosis leads to cardiac remodeling and dysfunction. Curcumae Rhizoma has been utilized in clinical trials treat a variety of cardiovascular illnesses, although its role myocardial is unknown.The purpose current study was explore the potential mechanism action anti-myocardial effects treatment with Rhizoma.The chemical components aqueous extract from were identified using GC-MS analysis. A prediction network describing relationship between MF established based on information...
There has been little literature about leukemia epidemiology in Nanjing recent years. We aimed to explore the incidence rate, gender and age distribution of using database city. The average yearly rate was 3.68/105 during 2003 - 2007 Nanjing. were no significant difference (x2 = 3.266, p > 0.05) or seasons 11.36, 0.05). highest group aged 80~ years (18.64/105). AML accounted for approximately 36.8% all leukemias. leukemia, especially population, relatively high Leukemia is major malignant...