A5058164746- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Pancreatic function and diabetes
- Acute Lymphoblastic Leukemia research
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Metabolomics and Mass Spectrometry Studies
- Diabetes and associated disorders
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Synthesis of Organic Compounds
- CNS Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Mesenchymal stem cell research
Nanjing Drum Tower Hospital
2015-2024
Peking University
2024
Hunan University
2024
Hunan Agricultural University
2024
Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
Nanjing University of Posts and Telecommunications
2023
Harvard University
2022
Massachusetts General Hospital
2022
Pingxiang University
2021
Robert Bosch (Germany)
2021
Over the last decade, hematopoietic stem cells transplantation (HSCT) has been increasingly used in treatment of severe progressive autoimmune diseases. We report a retrospective survey 183 multiple sclerosis (MS) patients, recorded database European Blood and Marrow Transplantation Group (EBMT). Transplant data were available from 178 patients who received an autologous graft. Overall, transplant related mortality (TRM) was 5.3% restricted to period 1995-2000, with no further TRM reported...
Chemotherapy is majorly used for the treatment of many cancers, including lymphoma. However, cytotoxic drugs, utilized in chemotherapy, can induce various side effects on normal tissues because their non-specific distribution body. Natural platelets are as drug carriers biocompatibility and specific targeting to vascular disorders, such cancer, inflammation, thrombosis. In this work, doxorubicin (DOX) was loaded natural Results showed that DOX into with high loading encapsulation efficiency....
Molecularly imprinted nanoparticles were prepared as surface-enhanced Raman scattering tags for the selective imaging of cancer cells and tissues against normal relying on use sialic acid-templated imprinting to recognize cells, which are over-expressed with acid at surface.
Autologous hematopoietic stem cell transplantation (AHSCT) has the potential to induce clinical remission in patients with newly diagnosed type 1 diabetes.The objective of study was examine impact AHSCT on lymphocytes and pancreatic β-cell function.This a nonrandomized, open-label prospective study.Thirteen new onset diabetes, 10 them diabetic ketoacidosis, were subjected cryopreserved CD34(+) progenitor cells followed up for 31-54 months.The numbers different subsets levels serum cytokines,...
Celastrol is an active compound extracted from the root bark of traditional Chinese medicine Tripterygium wilfordii Hook F. To investigate effect celastrol on human multiple myeloma cell cycle arrest and apoptosis explore its molecular mechanism action. The activity LP-1 proliferation was detected by WST-8 assay. celastrol-induced analyzed flow cytometry after propidium iodide staining. Nuclear translocation nuclear factor kappa B (NF-κB) observed fluorescence microscope. inhibited in a...
// Peipei Xu 1, * , Huaqin Zuo Rongfu Zhou 1 Fan Wang Liu Jian Ouyang and Bing Chen Department of Hematology, Drum Tower Hospital, School Medicine, Nanjing University, Nanjing, Jiangsu, 210093, P. R. China Co-first author Correspondence to: Xu, email: xu_peipei0618@163.com Ouyang, ouyangj211@163.com Chen, chenb211@163.com Keywords: platelet, anti-CD22 mAbs, doxorubicin, drug delivery system, lymphoma Received: October 24, 2016 Accepted: March 14, 2017 Published: April 06, ABSTRACT B-cell...
Central nervous system lymphoma (CNSL) is a type of hematological tumor. Treatment CNSL difficult due to the existence blood-brain barrier (BBB). Here, we used exosomes (Exos), extracellular vesicle, and iRGD construct new drug carrier use it load doxorubicin (DOX). The results in vitro vivo experiments showed that iRGD-Exo-DOX can efficiently securely transport DOX through BBB target tumor cells. suggest may cross brain microvascular endothelial cell-mediated endocytosis. Together, our...
Celastrol is an active compound extracted from the root bark of traditional Chinese medicine <i>Tripterygium wilfordii</i> Hook F. In this study, we investigated effect celastrol on lipopolysaccharide (LPS)-activated LP-1 human multiple myeloma cell-induced angiogenesis, and identified its molecular mechanism action. Migration umbilical vein endothelial cells (HUVECs) was tested using a wound-healing assay. HUVEC invasion assayed Transwell chamber. Cell surface expression...
Traditional Chinese medicine (TCM) which functions as chemotherapeutic or adjuvantly agents has been drawing a great many eyeballs for its easy obtain and significant antitumor effects accompanied with less toxic side effects. PDT (photodynamic therapy) utilizes the fact that certain compounds coined photosensitizers, when exposed to light of specific wavelength, are capable generating cytotoxic reactive oxygen species (ROS) such hydroxyl radical, hydrogen peroxide, superoxide kill cancer...
Abstract Protein arginine methyltransferase 5 (PRMT5), a histone responsible for the symmetric dimethylation of H4 on Arg 3 (H4R3me2s), is an enzyme that participates in tumor cell progression variety hematological malignancies. However, biological functions PRMT5 multiple myeloma (MM) and underlying molecular mechanisms remain unclear. In this study, we conducted bioinformatics analysis found expression was significantly upregulated MM. vitro vivo phenotypic experiments revealed knockdown...
To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis vitro.The proliferation of GA-treated cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cycle mitochondrial membrane potential were flow cytometric analysis. Caspase-3, -8 -9 detected colorimetric assay. Bcl-2 Bax analyzed Western blotting.GA inhibited growth a time- dose- dependent manner. GA induces but not normal bone marrow cells, which involved...