A5077381400- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Chronic Myeloid Leukemia Treatments
- Mesenchymal stem cell research
- Genetic diversity and population structure
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Plant biochemistry and biosynthesis
- Autophagy in Disease and Therapy
- Colorectal and Anal Carcinomas
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
Union Hospital
2023-2024
Jilin University
2021-2024
Nanjing Drum Tower Hospital
2015-2024
Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Weatherford College
2023
Union Hospital
2021-2023
Heilongjiang Bayi Agricultural University
2021
Fudan University
2021
Zhongshan Hospital
2021
Abstract Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial hold considerable promise for treatment DN. In this study, we investigated role progranulin (PGRN), secreted glycoprotein, mediating homeostasis and its therapeutic potential We found that level PGRN was significantly reduced kidney from STZ-induced mice patients with biopsy-proven DN compared healthy controls. model,...
Diabetic nephropathy (DN) has become the common and principal microvascular complication of diabetes that could lead to end-stage renal disease. It was reported endothelial-to-mesenchymal transition (EndMT) in glomeruli plays an important role DN. Enolase1 (ENO1) Lysine Methyltransferase 5A (KMT5A) were found modulate epithelial-to-mesenchymal some situations. In present study, we speculated KMT5A regulates ENO1 transcript, thus participating hyperglycemia-induced EndMT Our study represented...
Although amaryllis (Hippeastrum hybridum) plants are commonly used in physiological and ecological research, the extent of their genomic genetic resources remains limited. The development molecular markers is therefore great importance to accelerate improvements Hippeastrum species. In this study, a total 269 unique genes were defined that might regulate flower spathe amaryllis. addition, 2000 simple sequence repeats (SSRs) detected based on 171,462 de novo assembled unigenes from...
Digoxin has potential antitumor properties. This study investigated whether digoxin suppressed Burkitt's lymphoma (BL) cells. Raji and NAMALWA cells were exposed to digoxin, followed by assay of cell viability, apoptosis cycle. Western blotting was used analyze NF-κB activity. A xenograft model established for therapeutic efficacy evaluation. inhibited growth resulted in cycle arrest (G0/G1 cells; G2/M cells). DNA synthesis induced morphological apoptotic characteristics. Besides,...
The larval segment formation and secondary loss in echiurans is a special phenomenon, which considered to be one of the important characteristics evolutionary relationship between Echiura Annelida. To better understand molecular mechanism this we revealed transcriptome profile echiuran worm Urechis unicinctus using RNA-Seq technology. Twelve cDNA libraries U. larvae, late-trochophore (LT), early-segmentation larva (ES), segmentation (SL), worm-shaped (WL) were constructed. Totally 243,381...
Marriage has been reported as a beneficial factor associated with improved survival among cancer patients, but conflicting results have observed in cervical adenocarcinoma (AC). Thus, this study is aimed to examine the relationship between prognosis of AC and marital status. Eligible patients were selected from 2004 2015 using surveillance, epidemiology end (SEER) database. Cancer-specific (CSS) overall (OS) compared married unmarried groups. A total 3096 had identified, ones accounting for...
Diabetes mellitus can occur after acute pancreatitis (AP), but the accurate quantitative methods to predict post-acute diabetes (PPDM-A) are lacking. This retrospective study aimed establish a radiomics model based on contrast-enhanced computed tomography (CECT) for predicting PPDM-A.
Glanzmann thrombasthenia (GT) is a rare monogenic hemorrhagic disorder involving aggregation defect of non-nuclear platelets. In this study we generated induced pluripotent stem cells (iPSCs) from skin fibroblasts GT patient with complex heterogeneous mutations ITGA2B gene. GT-iPSCs could be successfully differentiated into platelets (GT-iPS-platelets). GT-iPS-platelets were CD41 −/CD42b +/CD61 − and platelet activation marker (PAC-1) negative after adenosine diphosphate (ADP) activation....
A set of 899 L. gmelinii expression sequence tags (ESTs), available at the National Center Biotechnology Information (NCBI), was employed to address feasibility on development simple repeat (SSR) markers for Larch species. Totally, 634 non-redundant unigenes including 145 contigs and 489 singletons were finally identified mainly involved in biosynthetic, metabolic processes response stress according BLASTX results, gene ontology (GO) categories Kyoto Encyclopedia Genes Genomes (KEGG) maps....
BACKGROUND:Myasthenia gravis (MG) is a progressive autoimmune disorder caused by the production of antibodies directed against acetylcholine receptors (AChRs), resulting in muscle weakness and fatigue. This study aimed to explore effect mechanism grilled nux vomica (GNV) experimental myasthenia (EAMG) rats. MATERIAL AND METHODS:Rat 97–116 peptides were used mediate disease EAMG model SPF female Lewis The treatment groups received (75 mg/kg, 150 225 mg/kg). autoantibody inflammatory cytokines...
Chromosomal translocations and rearrangements involving Mixed Lineage Leukemia (MLL) gene is associated with poor prognosis in AML. Extensive epigenetic changes were found this group of patients. In clinical study, we miR-181a expression level was significantly lower MLL-rearranged As an important epi-miRNA, the role as regulator leukemia has not been investigated before. overexpression enhanced total protein acetylation THP-1 cells, which harbor MLL-AF9 fusion gene, Mass Spectrum identified...
Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one the causes tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates proliferation, drug resistance, and radiation by regulating nuclear-cytoplasmic translocation important suppressor proteins or proto-oncoproteins. A large number studies have reported that inhibition CRM1 suppresses activation NF-κΒ. Thus, we hypothesize reversible inhibitor S109 may induce radiosensitivity in glioblastoma (GBM) NF-κΒ...
e15026 Background: ctDNA liquid biopsy technology has been widely used in the whole course of cancer management, from early screening and diagnosis tumors to tumor monitoring medication guidance. However, performances as a biomarker these scenarios are different among types. One possible reason is that types release amounts or cfDNA, therefore, we explored cfDNA levels this study. Methods: We collected 15913 peripheral blood samples 14686 patients with clinicopathologies, 256 pulmonary...
The aim of the present study was to identify genes under effect transforming growth factor‑β (TGF‑β1), high glucose (HG) and glucosamine (GlcN) in MES‑13 mesangial cells elucidate molecular mechanisms diabetic nephropathy (DN). gene expression datasets GSE2557 GSE2558 were downloaded from Gene Expression Omnibus database. Differentially expressed (DEGs) independently screened using GEO2R online tool. Ontology Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses performed...