A5100419300- Pancreatic and Hepatic Oncology Research
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Liver physiology and pathology
- Rheumatoid Arthritis Research and Therapies
- Fibroblast Growth Factor Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
- Influenza Virus Research Studies
- Mast cells and histamine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Amyotrophic Lateral Sclerosis Research
Xinyang College of Agriculture and Forestry
2025
Liaoning University of Traditional Chinese Medicine
2025
Shenyang Pharmaceutical University
2025
Xinjiang Medical University
2023-2025
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Yancheng Teachers University
2024
Central South University
2019-2024
Renji Hospital
2024
Shanghai Jiao Tong University
2014-2024
Autologous chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain characteristics of autologous CAR-T cells can delay availability. Relapse caused by escape after single-targeted another issue. Therefore, we aim to develop CRISPR-edited universal off-the-shelf CD19/CD22 dual-targeted as a novel r/r ALL.In this open-label dose-escalation phase I study, CD19/CD22-targeting (CTA101) with...
Acute myeloid leukemia (AML) is the with worst prognosis, and current knowledge of AML pathogenesis available therapies for remain limited. 40% patients exhibit elevated nuclear factor kappa B (NF-κB) activity, which provides a compelling rationale targeting NF-κB pathway in AML. Guanine nucleotide-binding protein-like 3-like protein (GNL3L) recently identified pro-oncogene that promotes activation variety malignancies. For first time, we comprehensively examined GNL3L expression AML,...
Background: Ovarian cancer is difficult to detect in its early stages, and it has a high potential for invasion metastasis, along with rate of recurrence. These factors contribute the poor prognosis reduced survival times patients this disease. The effectiveness conventional chemoradiotherapy remains limited. Nano-particles, as novel drug delivery system, have significant improving therapeutic efficacy overcoming these challenges. Methods: According expression level matrix...
Background: EpCAM or CD133 has been used as the tumor initiating cells (TICs) marker in hepatocellular carcinoma (HCC).We investigated whether expressing with both Ep-CAM and surface were more representative for TICs Huh7 cells.Methods: Four different phenotypes of + , -, -EpCAM -in sorted by flow cytometry.Then cell differentiation, self-renewal, drug-resistance, spheroid formation levels stem cell-related genes detected to compare characteristics TICs.The ability tumorigenicity was...
To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect AKI on podocyte kidney. Additional aims included using explore role post-injury fibrosis. Fifty BALB/C were randomly divided into control group (Ctr), sham (sham), 20 (renal ischemia, min reperfusion), 30 reperfusion) 40 reperfusion). Mice serum 24-h urine collected 8th, 9th, 10th, 14th, 28th days for urinary protein, creatinine (Scr) blood urea nitrogen (BUN) analysis....
Glioma is a lethal brain cancer and lacking effective therapies. Challenges include no therapeutic target, intra- intertumoral heterogeneity, inadequate drugs, an immunosuppressive microenvironment, etc. Deciphering the pathogenesis of gliomas finding out working mechanisms are urgent necessary for glioma treatment. Identification prognostic biomarkers targeting biomarker genes will be promising therapy.From our RNA-sequencing data oxidative phosphorylation (OXPHOS)-inhibition sensitive...
Suppressors of cytokine signaling, SOCS1 and SOCS3, are important negative regulators Janus kinase 2/signal transducers activators transcription which is constitutively activated in myeloproliferative neoplasms (MPNs) leukemia. Curcumin has been shown to possess anticancer activity through different mechanisms. However, whether curcumin can regulate the expression SOCS3 still unknown. Here, we found that elevated via triggering acetylation histone regions promoter K562 HEL cells. As a novel...
// Sugong Chen 1, * , Robert C. Fisher 2, Steven Signs 2 L. Alex Molina Anitha K. Shenoy 3 Maria-Cecilia Lopez Henry V. Baker John M. Koomen 4 Yi Haley Gittleman 5 Jill Barnholtz-Sloan Annamarie Berg D. Appelman 6 and Emina H. Huang 1 Department of Surgery, University Florida, Gainesville, Florida 32610, USA Stem Cell Biology Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, Molecular Genetics Microbiology, Oncology Proteomics, SRB3, Lee Moffitt Cancer...
Background Melanoma is a malignant tumor that originates from the canceration of melanocytes with high rate invasiveness and lethality. Immune escape has been regarded as an important mechanism for development, while treatment immune checkpoint inhibitors (ICIs) beneficial in restoring enhancing body’s anti-tumor response to kill cells. To date, ICIs therapy achieved remarkable efficacy treating melanoma patients. Despite significant clinical benefits ICIs, multiple complications such...
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck that significantly impacts patients' quality life, with chemotherapy resistance notably affecting prognosis. This study aims to identify prognostic biomarkers optimize treatment strategies for LSCC. Using data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), combined mitochondrial gene database analysis, we identified lncRNAs associated drug genes. Key long non-coding RNAs (lncRNAs)...
Tea plant can enrich a large amount of fluorine (F) in the cell wall its mature leaves, thus posing risk excessive intake F for tea consumers. This study investigated effect foliar calcium (Ca) application (0.05-1 mM) on accumulation leaves by analyzing association with materials, pectin methylesterification structure, and genes. Ca spray could effectively reduce level, content carbohydrates (excluding chelate fraction) degree leaves. Correlation analysis further revealed that leaf was...
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high postoperative recurrence and metastasis rates posing significant challenges to patient survival. Identifying reliable accessible prognostic markers essential for optimizing treatment strategies. This study investigates significance two preoperative hematological indices, [neutrophils × platelets]/[lymphocytes hemoglobin] (NP/LHb) ratio absolute monocyte count (Mono), in predicting overall survival CRC...
Abstract Herein, we describe the clinical and hematological features of three genetically related families predisposed to myeloproliferative neoplasms (MPNs). Using whole-exome sequencing, identified a c.1367delG mutation( p.Arg456fs) in CHST15 (NM_001270764), gene encoding type II transmembraneglycoproteinthat acts as sulfotransferase participates biosynthesis chondroitin sulfate E, germline somatic cells familial MPN. defects caused an increased JAK2V617F allele burden upregulated p-Stat3...
POEMS syndrome is a rare and complex plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, high M protein levels, skin changes. Understanding of has advanced rapidly since the 21st century. This study aims to summarize evaluate research status in past 23 years through bibliometric visualization analysis, identify focuses emerging hotspots for future.POEMS syndrome-related articles published between January 1, 2000, March 8, 2023, were systematically retrieved...
11,11′-Dideoxy-verticillin, a compound of the novel epidithiodioxopiprazine structural class, is isolated from traditional Chinese medicinal herb Shiraia bambusicola. The present study demonstrated for first time that 11,11′-dideoxy-verticillin has potent tyrosine kinase-inhibitory and anti-tumor activities. In cell-free ELISA kinase assay, significantly inhibited activities epidermal growth factor receptor (EGFR), vascular endothelial receptor-1/fms-like kinase-1 (VEGFR-1/Flt-1) human...
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with a 5-year survival rate <7%. Carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic (CEA) are often used to predict outcome malignancy independently. However, joint prognostic effect two tumor biomarkers has not been well determined. The study assessed role preoperative CA19-9 CEA in prediction resectable PDAC large cohort patients. enrolled 460 eligible patients who were ready undergo surgery for...