A5039482675- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Respiratory viral infections research
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Curcumin's Biomedical Applications
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Ginger and Zingiberaceae research
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Cancer therapeutics and mechanisms
- Neonatal Respiratory Health Research
- Advanced Glycation End Products research
- Atherosclerosis and Cardiovascular Diseases
- Pediatric health and respiratory diseases
- Sirtuins and Resveratrol in Medicine
- Drug Transport and Resistance Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mycobacterium research and diagnosis
- Cystic Fibrosis Research Advances
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
Guiyang Medical University
2018-2025
Affiliated Hospital of Guizhou Medical University
2021-2023
Nanjing Drum Tower Hospital
2022
Cytoskeleton (United States)
2018
Nagasaki University
2017
China Pharmaceutical University
2013-2014
Nanjing Medical University
2014
Atherosclerosis (AS) is a systemic disease characterized by lipid deposition in the blood vessel wall that urgently requires effective and safe therapeutic drugs for long-term treatment. An essential oil monomer-1,8-cineole (CIN) with ameliorative effects on vascular injuries has considerable potential preventing progression of AS because its antioxidant, anti-inflammation, cholesterol regulatory effects. However, high volatility instability CIN result low oral bioavailability short...
Abstract Transarterial chemoembolization (TACE) is considered the main treatment for intermediate and advanced liver cancer. Nevertheless, TACE may aggravate fibrosis in these patients, which could affect therapeutic effect after TACE. Pirfenidone (PFD) exhibits significant antifibrotic effects liver, primarily via inhibition of hepatic stellate cells (HSCs) activation. However, owing to high dose required effective treatment, oral administration PFD associated with several side effects....
The CaCO3 encapsulated liposome with pH sensitivity is an efficient carrier for the delivery of chemotherapeutic drugs. Herein, we provided innovative method that take advantage a W/O emulsion to prepare liposomes curcumin. both and curcumin (LCC) showed high reduced (the environment lysosomes). Due inherent CaCO3, LCC swelled released rapidly in acidic medium. lysosome escape capability promoted accumulation cytosol from was verified respect loaded (CLIPO). Despite similar cytotoxicity...
The combination of berberine (BER) and curcumin (CUR) has been verified with ameliorative effects on non-alcohol fatty liver disease (NAFLD). However, discrepant bioavailability biodistribution BER CUR remained an obstacle to achieve synergistic effects. Multilayer nanovesicles have great potential for the protection oral delivery drug combinations. Therein lies bile salts inserted liposomes, named as bilosomes, that possesses long residence time in gastrointestinal tract (GIT) permeability...
The combination of a photosensitizer and indoleamine-2,3 dioxygenase (IDO) inhibitor provides promising photoimmunotherapy (PIT) strategy for melanoma treatment. A dual drug delivery system offers potential approach optimizing the inhibitory effects PIT on proliferation metastasis. To develop based to study its efficacy in inhibiting We constructed multifunctional nano-porphyrin material (P18-APBA-HA) using photosensitizer-purpurin 18 (P18), hyaluronic acid (HA), 4-(aminomethyl)...
Tumor metastasis is the biggest challenge in cancer therapy. During process, metastatic cells could acquire stealth ability toward immune system through formation of a protection cloak by hijacking platelets (PTs). Heparins, heterogeneous mixture glycosaminoglycans, can inhibit cascades blocking P-selectin-mediated intercellular adhesion between tumor and PTs. In this study, low-molecular-weight heparin-coated doxorubicin-loaded liposome (LMWH-DOX-Lip) was developed for preventative The...
Abstract The mitochondria represent a potential target for the treatment of triple‐negative breast cancer (TNBC) and shikonin (SK) has shown remarkable therapeutic effects on TNBC. Herein, it is found that SK possesses potent inhibitory mitochondrial biogenesis via targeting polymerase gamma (POLG). However, its application restricted by poor aqueous solubility stability, therefore, biomimetic micelle to aid with tumor lesion accumulation mitochondria‐targeted delivery designed. A folic acid...
Purpose: An octreotide-conjugated polyamidoamine (PAMAM) dendrimer was synthesized and employed as nanocarriers of methotrexate (MTX), for targeting to the somatostatin receptors over-expressed tumor cells.Methods: PAMAM–PEG–octreotide (PPO) PAMAM–PEG (PPG) were characterized. The cellular uptake fluorescein isothiocyanate (FITC)-labeled PPO (PPO-FITC) PPG (PPG-FITC) investigated. cytotoxicity MTX nanoparticles conducted in MCF-7 cells. Besides, pharmacokinetics studies on carried out...
The combination of chemotherapy with natural products is a common strategy to enhance anticancer effects while alleviating the dose-dependent adverse cancer treatment. Oxymatrine (OMT) has been extensively reported as having activity. Doxorubicin (DOX) chemotherapeutic DNA-damaging agent used for treatment carcinoma. In this study, we investigated whether synergistic exist OMT and DOX using human colorectal cell (CRC) lines potential mechanisms involved in vitro vivo activities. MTT colony...
Pulmonary emphysema is a fatal lung disease caused by the progressive thinning, enlargement and destruction of alveoli that closely related to inflammation oxidative stress. Oxymatrine (OMT), as bioactive constituent traditional Chinese herbal Sophora flavescens, has great potential alleviate pulmonary via its anti-inflammatory antioxidative activities. administration most preferable way for treatment diseases. To improve in vivo stability retention OMT, OMT-loaded liposome with...
A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this therapy require a consecutive drug loading process because of different water-solubility these drugs. This study provides strategy "one-step" formation encapsulating both Dox Cur. We took advantage polyacrylic acid (PAA) calcium carbonate (CaCO3) to realise high entrapment efficiency (EE) pH-sensitive release using simplified...
Human respiratory syncytial virus (RSV) infection is the most important cause of acute lower tract in infants, neonates, and young children, even leading to hyperinflation atelectasis. Oxymatrine (OMT), originating from natural herbs, possessed potential antivirus activity against influenza A virus, Coxsackie B3 RSV, whereas absence an vivo study indicated difficulties overcoming physiological obstacles. Since RSV basically replicated lung tissue, this study, we fabricated characterized a...
Antimalarial drugs Dihydroartemisinin (DHA) and chloroquine phosphate (CQ) exhibit evident anti-cancer activity, particularly as combination therapy. DHA CQ therapy has been proved to higher cytotoxic effect in tumor cells lower toxicity normal than of artemisinin derivatives (ARTs) anticancer chemotherapy drugs. However, different physiochemical properties CQ, leading distinctive vivo outcomes, considerably limited their synergistic cancer treatment. Herein, we developed a lipid...