A5103097526- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Endoplasmic Reticulum Stress and Disease
- Antioxidant Activity and Oxidative Stress
- Air Quality and Health Impacts
- Medicinal Plants and Bioactive Compounds
- Hops Chemistry and Applications
- Heavy Metal Exposure and Toxicity
- Apelin-related biomedical research
- Cardiac Ischemia and Reperfusion
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy metals in environment
- Bone and Dental Protein Studies
- Peroxisome Proliferator-Activated Receptors
- Ginger and Zingiberaceae research
- Fluoride Effects and Removal
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
Affiliated Hospital of Guizhou Medical University
2021-2023
Guiyang Medical University
2021-2023
Yueyang Hospital
2004
Shanghai University of Traditional Chinese Medicine
2004
Heavy metal exposure has well-established health risks, but its impact on all-cause mortality through renal function remains unclear. This study used data from 1,342 participants aged≥60 years in the National Health and Nutrition Examination Survey (2005-2018). A cross-sectional design was employed, with heavy composite scores derived using least absolute shrinkage selection operator regression. Multivariate Cox proportional hazards models assessed relationship between mortality, while...
Fluorosis primarily manifests as bone damage in the form of dental fluorosis and skeletal represents a critical global public health challenge. However, few studies have examined autophagy-related signaling pathways fluorosis. This study aimed to investigate effect fluoride on autophagy osteoblasts using comprehensive methods explore role PI3K/AKT/mTOR pathway regulating fluoride-induced osteoblasts. Sprague–Dawley (SD) rats were exposed different concentrations (NaF: 5, 50, 100 mg/L) for...
Essential oil from fructus of Alpinia zerumbet (EOFAZ) protects vascular endothelial cell (VEC) injury. Stimulation and injury factors can induce phenotypic changes in VECs the occurrence endothelial-mesenchymal transformation (EndMT), accelerating development cardiovascular diseases. We investigated role EOFAZ EndMT induced by transforming growth factor-β1 (TGF-β1). All experiments were performed using human umbilical vein cells (HUVECs). HUVECs preincubated with for 2 hours then...
Abstract Background Endoplasmic reticulum (ER) stress-mediated phenotypic switching of vascular smooth muscle cells (VSMCs) is key to calcification (VC) in patients with chronic kidney disease (CKD). Terpinen-4-ol exerts protective effect against cardiovascular disease, but its role and specific mechanism VC remain unclear. We explored whether terpinen-4-ol alleviates ER through sirtuin 1 (sirt1) elucidated provide evidence for application the clinical prevention treatment VC. Methods In...
This study aimed to observe the effect of terpinen-4-ol(T4O) on proliferation vascular smooth muscle cells(VSMCs) exposed high glucose(HG) and reveal mechanism via Krüppel-like factor 4(KLF4)/nuclear kappaB(NF-κB) signaling pathway. The VSMCs were first incubated with T4O for 2 h then cultured HG 48 establish model inflammatory injury. proliferation, cell cycle, migration rate examined by MTT method, flow cytometry, wound healing assay, respectively. content cytokines including...