A5100425665- Curcumin's Biomedical Applications
- Voice and Speech Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Dysphagia Assessment and Management
- Hydrogels: synthesis, properties, applications
- Pain Mechanisms and Treatments
- Tracheal and airway disorders
- Neurological Disease Mechanisms and Treatments
- Nutrition and Health in Aging
- Frailty in Older Adults
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Head and Neck Cancer Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Neurotoxicity Research
- Genomics, phytochemicals, and oxidative stress
- Retinoids in leukemia and cellular processes
- Botulinum Toxin and Related Neurological Disorders
- Polymer Surface Interaction Studies
- Sympathectomy and Hyperhidrosis Treatments
- Anesthesia and Sedative Agents
- Advanced Drug Delivery Systems
- Medicinal Plant Pharmacodynamics Research
- Wnt/β-catenin signaling in development and cancer
- Flavonoids in Medical Research
Shanghai Municipal Center For Disease Control Prevention
2021-2025
Capital Medical University
2015-2024
Beijing Geriatric Hospital
2017-2024
Shanghai Jiao Tong University
2024
Beijing Friendship Hospital
2005-2023
First People's Hospital of Yunnan Province
2023
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
West China Medical Center of Sichuan University
2022
Chinese Institute for Brain Research
2018-2021
Frailty in older adults predicts dependence and mortality is a major challenge for healthcare systems countries with rapidly aging populations. Little known about frailty China. We investigated the prevalence associated risk factors of China.Cross-sectional.Data were obtained from China Comprehensive Geriatric Assessment Study, conducted 2011-12, which was first uniform comprehensive assessment system adopted China.Older 7 cities selected based on well-established cluster, stratification,...
MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type 2 diabetes exhibited substantial downregulation sciatic nerve tissue. Systemic administration mimics to elevated levels plasma and tissue substantially increased motor sensory conduction velocities by 29 11%, respectively, regional blood flow 50% Treatment also considerably decreased response db/db...
The mechanism underlying the differential cytotoxicity of curcumin in various cancer types, however, remains largely unclear. aims this study is to examine concentration- and time-related effects on two different breast cells, MCF-7 MDA-MB-231, investigated functional changes induced by treatment, as well their relationship PI3K/Akt-SKP2-Cip/Kips pathway. First, WST-1 clonogenic assay were performed determine MDA-MB-231 cells. Then, expression CDK interacting protein/Kinase inhibitory...
Curcumin (CUR) has antioxidant and anti-inflammatory effects that are beneficial to Alzheimer's disease (AD). However, the poor solubility high instability of CUR compromise its application greatly. In this study, CUR-encapsulated chitosan-coated poly (lactic-co-glycolic acid) nanoparticles (CUR-CS-PLGA-NPs) hydroxypropyl-β-cyclodextrin-encapsulated complexes (CUR/HP-β-CD inclusion complexes) were developed compared through intranasal administration. vitro studies indicated in CUR/HP-β-CD...
Abstract Background COVID-19 lockdowns may lead to physical inactivity, a major risk factor for non-communicable diseases. This study aims determine: 1) the trajectory in daily step counts before, during and after lockdown China, 2) characteristics associated with trajectories. Methods From December 2019 July 2020, smartphone-based were continuously collected 815 Chinese adults residing Shanghai over 202 days across three phases: during, lockdown. Participant reported, height, weight body...
The origin of poly(N-isopropylacrylamide) (PNIPAM) cononsolvency in tetrahydrofuran-water (THF-water) mixture was studied from the point view mixed solvent structure. dynamic equilibrium THF-water composition fluctuation system found to be main variable for this effect. Temperature and THF content dependences were by a combination small angle neutron scattering (SANS), laser light scattering, viscometry. A lower critical solution temperature (LCST) type phase diagram established SANS....
Purpose: A novel brain targeting drug delivery system based on OX26 antibody conjugation PEGylated cationic solid lipid nanoparticles (OX26-PEG-CSLN) was prepared.
Curcumin, a natural polyphenol antioxidant extracted from the root of turmeric ( Curcuma longa ), can induce apoptosis and DNA demethylation in several types cancer cells. However, mechanism its anticancer potentials effects potential relationships between these outcomes have not been clearly elucidated. In present study, curcumin on proliferation, colony formation, migration human gastric cells (hGCCs) were explored. Reactive oxygen species (ROS) levels, mitochondrial damage,...
Background: Little is known about whether sarcopenia predicts incident depressive symptoms in older adults. Using the nationally representative data from China Health and Retirement Longitudinal Study (CHARLS), we conducted cross-sectional longitudinal analyses to estimate association between among Methods: The sample comprised 7,706 participants aged at least 60 years (50.6% women; mean age 68.0 ± 6.5) CHARLS 2015. Based on Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria,...
Accurate tooth segmentation and numbering are the cornerstones of efficient automatic dental diagnosis treatment. In this paper, a multitask learning architecture has been proposed for accurate in panoramic X-ray images. A graph convolution network was applied annotation target region, modified convolutional neural network-based detection subnetwork (DSN) used recognition boundary regression, an effective region (RSSN) segmentation. The features extracted using RSSN DSN were fused to...
Heavy metal exposure has well-established health risks, but its impact on all-cause mortality through renal function remains unclear. This study used data from 1,342 participants aged≥60 years in the National Health and Nutrition Examination Survey (2005-2018). A cross-sectional design was employed, with heavy composite scores derived using least absolute shrinkage selection operator regression. Multivariate Cox proportional hazards models assessed relationship between mortality, while...
Abstract A novel semi‐IPN nanocomposite hydrogel (CMC/PNIPA/Clay hydrogel) based on linear sodium carboxymethylcellulose (CMC) and poly( N ‐isopropylacrylamide) (PNIPA) crosslinked by inorganic clay was prepared. The structure morphology of these hydrogels were investigated their swelling deswelling kinetics studied in detail. TEM images showed that the substantially exfoliated to form nano‐dimension platelets dispersed homogeneously acted as a multifunctional crosslinker. CMC/PNIPA/Clay...
Hypertension and frailty are associated often coexist in older adults. Few studies have examined the association between hypertension Chinese population. We explored prevalence of factors with as well whether could identify patients at risk adverse outcomes among adults hypertension. Data were from Beijing Longitudinal Study Aging. A total 1111 hypertensive participants aged ≥60 years old who completed comprehensive geriatrics assessment included. All followed up for 8 years. The number...