A5100414360- Antibiotic Resistance in Bacteria
- Curcumin's Biomedical Applications
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Urinary Tract Infections Management
- Vibrio bacteria research studies
- Synthesis and Characterization of Heterocyclic Compounds
- Bacterial Identification and Susceptibility Testing
- Advanced Drug Delivery Systems
- Genomics, phytochemicals, and oxidative stress
- Alcohol Consumption and Health Effects
- Antibiotic Use and Resistance
- Biochemical effects in animals
- Electrospun Nanofibers in Biomedical Applications
- Drug-Induced Hepatotoxicity and Protection
- Plant Micronutrient Interactions and Effects
- Escherichia coli research studies
- Galectins and Cancer Biology
- Silicon Effects in Agriculture
- Phenothiazines and Benzothiazines Synthesis and Activities
- Proteoglycans and glycosaminoglycans research
- Synthesis of Tetrazole Derivatives
- Nuclear Receptors and Signaling
Hebei North University
2025
Guangdong Ocean University
2018-2024
Affiliated Hospital of Guizhou Medical University
2022-2023
Guiyang Medical University
2022-2023
Ningxia Medical University
2023
Jiangsu University
2022-2023
Second Affiliated Hospital of Zhengzhou University
2023
Sichuan University
2020-2022
XinHua Hospital
2009-2022
West China Hospital of Sichuan University
2020-2022
The aims of this study were to characterize the curcumin/cyclodextrin polymer inclusion complex using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and UV⁻vis spectroscopy, determine antioxidant activity by methods scavenging 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals assays 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays. inhibitory effect on A375 cells was also investigated CCK-8 assay, Annexin-V/PI...
Curcumin, a natural polyphenol antioxidant extracted from the root of turmeric ( Curcuma longa ), can induce apoptosis and DNA demethylation in several types cancer cells. However, mechanism its anticancer potentials effects potential relationships between these outcomes have not been clearly elucidated. In present study, curcumin on proliferation, colony formation, migration human gastric cells (hGCCs) were explored. Reactive oxygen species (ROS) levels, mitochondrial damage,...
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has become a serious global health concern due to the limited treatment options. The primary resistance mechanism in CRPA involves production of metallo-β-lactamases (MBLs), making MBL-producing P. significant component cases. To understand prevalence hospitals northern China, we conducted preliminary screening and identification 143 clinical isolates collected from various departments tertiary hospital between 2021 2023, analyzing trends...
Outbreaks caused by Klebsiella pneumoniae producing carbapenemases and other β-lactamases have been reported. Four neonates admitted to a neonatal intensive care unit (NICU) in Chinese hospital developed respiratory infection while receiving care. In all four cases, multidrug-resistant K. was isolated from multiple specimens, leading additional characterization of these organisms investigation the local environment NICU. Multiple β-lactamase genes, including bla TEM-1, IMP-4, DHA-1 CTX-M-14,...
Long-term manganese exposure causes a neurodegenerative disorder referred to as poisoning, but the mechanism remains unclear and no specific treatment is available. Oxidative stress widely recognised one of main manganese-induced neurotoxicity. In recent years, role histone acetylation in diseases has been concerned. curcumin natural polyphenol compound extracted from rhizome turmeric exhibits both antioxidant neuroprotective properties. Therefore, we aimed investigate whether how protects...
Polymyxins have become an important treatment option for carbapenem-resistant organisms (CRO) infections. However, there is a rare of clinical studies on colistin sulfate. This study sought to investigate the rate improvement and adverse reactions sulfate in severe infections caused by CRO critically ill patients assess factors associated with 28-day all-cause mortality.This multicenter retrospective cohort included intensive care unit (ICU) who received due during July 2021 May 2022. The...
Background: Oral route of administration is preferred for treating breast cancer, especially when continued disease management with good tolerability required; however, orally administered chemotherapeutics combined near-infrared (NIR) dyes are hindered by the low bioavailability, insufficient desired therapeutic efficacy. In this study, we developed a hybrid self-microemulsifying drug delivery system co-loading curcumin-phospholipid complex and NIR dye IR780 (CUR/IR780@SMEDDS), to achieve...
Curcumin has a wide range of pharmacological activities, which can be used to treat tumors, inflammation and other diseases. However, curcumin's poor solubility low bioavailability limit its application. In this article, the structure curcumin was modified with boron trifluoride ether change fluorescent labeling. The compounds were then embedded into hydrophobic cavity α-cyclodextrin hydroxypropyl β-cyclodextrin form inclusion complexes. two complexes have excellent photophysical properties,...
ABSTRACT Two cases of pulmonary infection due to strains multidrug-resistant Klebsiella pneumoniae were investigated. Beta-lactamase determinants, such as bla IMP-4 and SHV-12 , the 16S rRNA methyltransferase-encoding gene armA detected in these plasmid-bearing organisms. The integron-borne contained intervening sequences highly related those a Vibrio cholerae O139 plasmid found Hangzhou, China.
This study was to examine the protective effects of curcumin/cyclodextrin polymer inclusion complex (CUR/CDP) on ethanol-induced liver injury in mice and explore its potential mechanisms. In acute mouse model, pretreatment with silymarin, cyclodextrin (CDP), curcumin (CUR) CUR/CDP at low, middle, high doses were evaluated by biochemical histopathological examination. The index, alanine aminotransferase (ALT), aspartate (AST), lactate dehydrogenase (LDH) levels serum measured. superoxide...
Abstract Multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) clones typically co-exist in hospital wards, but often certain will dominate. The factors driving this dominance are largely unclear. This study began from a genomic epidemiology analysis and followed by multiple approaches to identify the potential mechanisms successful spread of dominant clone. 638 patients 50-bed ICU were screened. 171 (26.8%) 21 had CRKP swabs clinical specimens, respectively. Many (39.8% those with...
In this work, poly(N,N-diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining contents INH tablets under different external stimuli conditions constructing its logic gate computing systems. The triple-sensitive CV film system toward pH, temperature salt concentration observed explored....
Currently, an increasing number of hv-CRKP strains have been reported and pose a substantial threat to public health worldwide, because these are considered be simultaneously hypervirulent, carbapenem resistant, transmissible. In this study, we provided complete transition process CRKP from their early emergence outbreak in 10 years.
Aluminum (Al) toxicity in acidic soils poses significant challenges to crop growth and development. However, the response mechanism of Shatian pomelo (Citrus maxima ‘Shatian Yu’) roots Al remains poorly understood. This study employed root phenotype analysis, physiological index measurement, transcriptome quantitative PCR (qPCR) validation investigate effects on roots. The findings revealed that inhibited development, resulting reduced biomass, total length, surface area, volume, average...
The increasing prevalence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) strains in the hospital setting represents an emerging challenge to clinical treatment for (PA) infections, as range therapeutic agents active against these pathogens becomes increasingly constrained. This study demonstrated first time that fosfomycin (FOS) combined with rifampin (RIF) showed strong synergistic effects CRPA and carbapenem-susceptible PA, 100% rates. Additionally, time-killing curve further proves...
Danyang Peng, Fan Zhang, Yinyin Chen, Congyi Zhao, Jingjing Niu, Jianxu Yang, Zhifeng Li, Chao Shi Qiu, Huifeng Bingyu Qin, Xiang Fang, Suping Guo, Ying Liu, Huanzhang Shao