A5100369300- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Prostate Cancer Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Seaweed-derived Bioactive Compounds
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Obsessive-Compulsive Spectrum Disorders
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Protein Hydrolysis and Bioactive Peptides
- Cancer-related Molecular Pathways
- Acupuncture Treatment Research Studies
- Pluripotent Stem Cells Research
- Cancer Research and Treatments
- Curcumin's Biomedical Applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer survivorship and care
- Healthcare and Venom Research
- Cancer-related molecular mechanisms research
West China Second University Hospital of Sichuan University
2022-2025
Sichuan University
2022-2025
Virginia Commonwealth University
2025
Jilin University
2024
Peking University
2019-2024
Beihua University
2022-2024
Singapore General Hospital
2022-2024
Guangxi Medical University
2021-2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Abstract The importance of MCL-1 in leukemogenesis has prompted development antagonists e.g., S63845, MIK665. However, their effectiveness acute myeloid leukemia (AML) is limited by compensatory accumulation via the ubiquitin proteasome system. Here, we investigated mechanisms which kinase inhibitors with Src inhibitory activity bosutinib (SKI-606) might circumvent this phenomenon. antagonist/SKI-606 co-administration synergistically induced apoptosis diverse AML cell lines. Consistently, or...
Evidence suggests that probiotic interventions reduce non-communicable diseases (NCDs) risk. However, its therapeutic effect and mechanism are still unclear. To evaluate the hypocholesterolemic of Lactobacillus plantarum H6 (L.p H6), a new commercial patent strain capable preventing hypercholesterolemia, in depth, three states were prepared, namely, viable (vH6), heat-inactivated (iH6), ultrasonically-lysed (uH6) bacteria cells. The results showed v/i/uH6 cells could lower serum liver blood...
Abstract Aim To clarify the concept of oral frailty to provide a clear and standardized conceptual basis for further research in older people. Design Rodgers Knafl's evolutionary analysis approach. Methods The narrative detailedly extracted synthesized attributes frailty, as well its antecedents, consequences related terms under guidance Rodgers' method. Data Sources Multiple databases including Pubmed, CINAHL Cochrane were searched using selected search ‘oral frail*’, health’ ‘aged’...
Aim: To explore the specific histone acetylation sites and oxidative stress-related genes that are associated with pathogenesis of manganese toxicity. Methods: We employed liquid chromatography-tandem mass spectrometry bioinformatics analysis to identify acetylated proteins in striatum subchronic manganese-intoxicated rats. Results: identified a total 12 differentially modified sites: H3K9ac, H3K14ac, H3K18ac, H3K56ac H3K79ac were upregulated H3K27ac, H3K36ac, H4K91ac, H4K79ac, H4K31ac,...
Effectively reducing the inflammatory response after spinal cord injury (SCI) is a challenging clinical problem and subject of active investigation. This study employed porous scaffold-based three dimensional long-term culture technique to obtain human umbilical mesenchymal stem cell (hUC-MSC)-derived Small Extracellular Vesicles (sEVs) (three over time, "4D-sEVs"). Moreover, vesicle size, number, inner protein concentrations MSC 4D-sEVs contained altered profiles compared with those derived...
By combining virtual screening and experimental assay, two angiotensin I-converting enzyme inhibitory peptides, TVLYEH LQAGGLF, were identified from the protease K hydrolysate of Spirulina protein, showed significantly antihypertensive effect in vivo .
Long-term manganese exposure causes a neurodegenerative disorder referred to as poisoning, but the mechanism remains unclear and no specific treatment is available. Oxidative stress widely recognised one of main manganese-induced neurotoxicity. In recent years, role histone acetylation in diseases has been concerned. curcumin natural polyphenol compound extracted from rhizome turmeric exhibits both antioxidant neuroprotective properties. Therefore, we aimed investigate whether how protects...
To effectively quantify the impact of distributed photovoltaic (PV) access on distribution network, this paper proposes a comprehensive evaluation method PV grid connection combining subjective and objective combination assignment technique for order preference by similarity to an ideal solution (TOPSIS)—rank sum ratio (RSR) (TOPSIS-RSR) method. Based traditional network system, system has been constructed. It fully considers new development requirements environmental friendliness absorptive...
This study aimed to evaluate the impact of a short insemination procedure on embryo development, assess reliability fertilization check prior appearance pronuclei and elucidate role rescue intracytoplasmic sperm injection (R-ICSI). Patients who had ≥9 eggs, were aged <38 years normal semen samples included. The sibling eggs each patient divided into two groups; one half for conventional in vitro (IVF; time, 20 h) other (insemination 5 h). R‑ICSI was performed where total failure (TFF) deemed...
Cyclin B2 (CCNB2) belongs to type B cell cycle family protein, which is located on chromosome 15q22, and it binds cyclin-dependent kinases (CDKs) regulate their activities. In this study, 103 high-throughput datasets related all subtypes of lung cancer (LC) cerebral ischemic stroke (CIS) with the data CCNB2 expression were collected. The analysis standard mean deviation (SMD) summary receiver operating characteristic (SROC) reflecting status demonstrated significant up-regulation in LC CIS...
Carbon dots (CDs) have been extensively explored to show good optical features, low toxicity, and biocompatibility. Herein, we report the new synthesis of forsythia-derived CDs (F-CDs) their incorporation into Nylon-11 nanofibers for improved mechanical properties F-CDs are prepared from a Chinese herb forsythia via magnetic hyperthermia method in 90 s without use any organic solvents. The as-prepared with rich surface functional groups can be well embedded electrospinning, providing...
Chemotherapy remains the cornerstone of pancreatic cancer treatment. However, dense interstitial and immunosuppressive microenvironment frequently render ineffective anti-tumor activity chemotherapeutic agents. Macrophages play a key role in tumor immunomodulation. In this study, we found that low molecular weight fucoidan (LF2) directly regulated differentiation mononuclear macrophages into CD86+ M1 phenotype. LF2 significantly upregulated expressions macrophage-specific cytokines,...