Gengyu Cen

ORCID: 0000-0003-3609-6633
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About
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Research Areas
  • Acute Ischemic Stroke Management
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cerebrovascular and Carotid Artery Diseases
  • Cancer-related molecular mechanisms research
  • Brain Metastases and Treatment
  • MicroRNA in disease regulation
  • Retinal Diseases and Treatments
  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Cancer Mechanisms and Therapy
  • Spinal Hematomas and Complications
  • Glioma Diagnosis and Treatment
  • Neurological Disorders and Treatments
  • Venous Thromboembolism Diagnosis and Management
  • HIV, Drug Use, Sexual Risk
  • Inflammatory Biomarkers in Disease Prognosis
  • MRI in cancer diagnosis
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Long-Term Effects of COVID-19
  • Intracranial Aneurysms: Treatment and Complications

First Affiliated Hospital of GuangXi Medical University
2021-2025

Guangxi Medical University
2021-2025

To investigate the clinical features and risk factors of human immunodeficiency virus (HIV)-infected patients with intracerebral hemorrhage (ICH). The HIV-infected without ICH group were matched to patients. Logistic regression analysis using 1:1 propensity score matching (PSM) was performed independent for in receiver operating characteristic (ROC) curve configured calculate optimal predictors A total 59 180 included. cohort 118 ascertained utilizing PSM. Multivariate binary logistic...

10.3389/fcimb.2024.1498327 article EN cc-by Frontiers in Cellular and Infection Microbiology 2025-01-07

Cyclin B2 (CCNB2) belongs to type B cell cycle family protein, which is located on chromosome 15q22, and it binds cyclin-dependent kinases (CDKs) regulate their activities. In this study, 103 high-throughput datasets related all subtypes of lung cancer (LC) cerebral ischemic stroke (CIS) with the data CCNB2 expression were collected. The analysis standard mean deviation (SMD) summary receiver operating characteristic (SROC) reflecting status demonstrated significant up-regulation in LC CIS...

10.3389/fnint.2022.854540 article EN cc-by Frontiers in Integrative Neuroscience 2022-07-19

The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. Gene Expression Omnibus (GEO) database utilized obtain four COVID-19 datasets and two stroke datasets. Thereafter, we identified key modules via weighted gene co-expression network analysis, following which COVID-19- stroke-related crucial were crossed identify common genes COVID-19-related intersected with hub screened Cytoscape software discover...

10.1155/2022/4526022 article EN cc-by Oxidative Medicine and Cellular Longevity 2022-05-09

To investigate the hypercoagulability of hepatocellular carcinoma (HCC)-related cerebral infarction (HCRCI) with thromboelastography (TEG).A multicenter prospective study was conducted in HCRCI patients, HCC patients without infarction, and acute (ACI) between January 2016 December 2019. TEG parameters laboratory clinical data were collected compared among three groups. confirm independent risk factors HCRCI, multivariate analyses conducted. Receiver operating characteristic (ROC) curves...

10.1002/brb3.2961 article EN cc-by Brain and Behavior 2023-03-16

To investigate the pathogenesis of cancer-related ischemic stroke (CRIS) and to search for reliable biomarkers CRIS.

10.2147/jir.s493406 article EN cc-by-nc Journal of Inflammation Research 2024-11-01

BACKGROUND: Stroke is one of the leading causes disability and mortality worldwide. OBJECTIVE: To identify regulatory network microRNAs (miRNAs) mRNAs to clarify molecular mechanisms in stroke. METHODS: Four miRNA datasets two mRNA stroke were downloaded from GEO database. R-Studio was utilized analyze differentially expressed miRNAs (DEmiRNAs) (DEmRNAs) blood control patients. FunRich software conduct GO biological pathway analysis on DEmiRNAs, search for transcription factors (TFs)...

10.3233/thc-231357 article EN Technology and Health Care 2024-05-16

The diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but clinical features pathogenesis patients with colorectal (CRC) ICH are still well known.To investigate underlying CRC.A retrospective review CRC complicated from three centers between January 2014 December 2020 was performed. Clinical data such as laboratory examinations, imaging features, prognosis, were analyzed.Of 16673 identified patients, 20 (0.12%) suffered ICH. There 13 males 7...

10.4251/wjgo.v13.i12.2180 article EN World Journal of Gastrointestinal Oncology 2021-12-08

To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).Clinical data SAH in patients with active from January 2010 to December 2020 at four centers were retrospectively reviewed. Patients without matched group. Logistic regression was applied independent cancer, after a 1:1 propensity score matching (PSM). A receiver operator characteristic curve configured calculate optimal cut-off value joint predictive factor for...

10.3389/fncel.2022.813084 article EN cc-by Frontiers in Cellular Neuroscience 2022-02-07

Some acute ischemic stroke (AIS) patients still suffer from early neurological deterioration (END) after receiving intravenous thrombolysis (IVT), and these often have a poor prognosis. The purpose of our study is to observe the efficacy safety human urinary kallidinogenase (HUK) treatment in with END.

10.1002/brb3.2524 article EN Brain and Behavior 2022-02-13

Abstract Background: Deep venous thrombosis (DVT) including limber and pulmonary embolism is a common complication of cancer. DVT ischemic stroke may independently or jointly lead to poor prognosis in cancer patients. Case presentation: A 36-year-old female patient, received insertion inferior vena cava filter oral rivaroxaban for deep limbers artery, was suspected cervical three-month history vaginal discharge transferred our hospital further treatment. After tissue biopsy pelvic cavity...

10.21203/rs.3.rs-2690374/v1 preprint EN cc-by Research Square (Research Square) 2023-03-21

<title>Abstract</title> To identify the regulatory network of microRNAs (miRNAs) and mRNAs to clarify molecular mechanisms in stroke. Four miRNA datasets two mRNA stroke were downloaded from GEO database. R-Studio was utilized analyze differentially expressed miRNAs (DEmiRNAs) (DEmRNAs) blood control patients. FunRich software conduct GO biological pathway analysis on DEmiRNAs, search for transcription factors (TFs) DEmiRNAs. Subsequently, we used miRDB, miRTarBase, TargetScan DEmiRNAs...

10.21203/rs.3.rs-2642141/v1 preprint EN cc-by Research Square (Research Square) 2023-03-22
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