A5068492120- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Genetics and Neurodevelopmental Disorders
- Infectious Diseases and Tuberculosis
- Growth Hormone and Insulin-like Growth Factors
- Connective tissue disorders research
- Mesenchymal stem cell research
- Orthopedic Infections and Treatments
- Anesthesia and Neurotoxicity Research
- Liver physiology and pathology
- Flavonoids in Medical Research
- Muscle activation and electromyography studies
- Atherosclerosis and Cardiovascular Diseases
- Nerve injury and regeneration
- Bioactive Compounds and Antitumor Agents
- Sphingolipid Metabolism and Signaling
- Galectins and Cancer Biology
- Cholesterol and Lipid Metabolism
Guangxi Medical University
2024-2025
First Affiliated Hospital of GuangXi Medical University
2024-2025
Ningbo University Affiliated Hospital
2024
Chongqing University of Technology
2020-2021
Chongqing Population and Family Planning Science and Technology Research Institute
2020-2021
The People's Hospital of Guangxi Zhuang Autonomous Region
2021
Ningbo University
2017-2019
Dalian Medical University
2019
Chongqing Medical University
2019
Second Affiliated Hospital of Chongqing Medical University
2019
Inflammation impairs macrophage cholesterol clearance from vascular tissues and promotes atherosclerosis. Inflammatory macrophages suppress expression of the transcription cofactor interferon regulatory factor 2-binding protein 2 (IRF2BP2), genetic variants near IRF2BP2 associate with ischemic heart disease progression in humans.To test whether affects atherosclerosis mice humans.We generated that delete macrophages. IRF2BP2-deficient worsened irradiated low-density lipoprotein receptor...
Ischemic stroke causes neuronal cell death and triggers a cascade of inflammatory signals that contribute to secondary brain damage. Microglia, the brain-resident macrophages remove dead neurons, play critical role in brain's response ischemic injury. Our previous studies showed IRF2BP2 regulates peripheral macrophage polarization, limits their reduces susceptibility atherosclerosis. Here, we show loss microglia leads increased cytokine expression lipopolysaccharide challenge impaired...
The present study performed two distinct meta-analyses with common outcomes (sperm parameters); one was in obese individuals (and non-obese controls) and the other diabetic non-diabetic controls).PubMed, Embase, Cochrane library, Web of Science, Scopus databases were searched to collect clinical studies related effects obesity diabetes on male sperm from inception 1st February 2021. Statistical using RevMan 5.4 software. Stata16 software used detect publication bias. methodological quality...
Abstract Acute respiratory distress syndrome (ARDS) is a severe illness characterized by uncontrolled inflammation. The resolution of inflammation tightly regulated event controlled endogenous mediators, such as resolvin D1 (RvD1). Cyclooxygenase-2 (COX-2) has been reported to promote inflammation, along with PGE2, in the initiation well prompting resolution, PGD2 acting later phase Our previous work demonstrated that RvD1 enhanced COX-2 and expression resolve In this study, we investigated...
To investigate the clinical features and risk factors of human immunodeficiency virus (HIV)-infected patients with intracerebral hemorrhage (ICH). The HIV-infected without ICH group were matched to patients. Logistic regression analysis using 1:1 propensity score matching (PSM) was performed independent for in receiver operating characteristic (ROC) curve configured calculate optimal predictors A total 59 180 included. cohort 118 ascertained utilizing PSM. Multivariate binary logistic...
Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, has wide range biological activities, pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects on neurons through its anti-apoptotic effect, inhibition neuroinflammation oxidative...
Abstract Depression is a highly complex global disabling psychiatric disorder. Unfortunately, the currently available antidepressants are not effective in significant percentage of patients. Therefore, underlying mechanisms depression must be explored at molecular level to discover new candidate targets for treatment. Behavioural and depression‐like endophenotypes have been observed cyclic AMP response element‐binding protein‐regulated transcription coactivator 1 ( Crtc1 ) knockout mice;...
Abstract Background Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder of heterogeneous nature. Secreted frizzled-related protein (SFRP) 5 an anti-inflammatory adipokine implicated in metabolic homeostasis. We aimed to confirm the correlation between SFRP5, inflammation and PCOS, investigate predictive value SFRP5 for PCOS involvement metformin treated PCOS. Methods This retrospective case–control study included 140 33 control women. Sixty seven women were detecting serum level...
Enhanced postnatal care (EPC) increases resilience to adversity in adulthood. Since microglia participate shaping neural circuits, we asked how ablation of an inflammation-suppressing factor IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) would affect the responses EPC. Mice lacking (KO) and littermate controls (WT) were subjected EPC during first 3 weeks after birth. reduced anxiety WT but not KO mice. This was associated with inflammatory cytokine expression hypothalamus. Whole...
An enriched environmental exposure has been shown to promote hippocampal neurogenesis, which is an important mechanism underlying enrichment-induced memory improvement. The cAMP response element-binding protein stimulus-inducible factor in the brain and crucial for neurogenesis ability. Calmodulin activation activity-induced phosphorylation. aim of this study was explore effects calmodulin on spatial improvement rats exposed environment.Ninety-six neonatal pups were assigned four groups:...
Let 𝔽 q be the finite field of elements and f a nonzero polynomial over . For each b ϵ , let N (f = b) denote number -rational points on affine hypersurface b. We obtain formula for class hypersurfaces by using greatest invariant factors degree matrices under certain cases, which generalizes previously known results. also give another simple direct proof to
Neurological diseases bring great mental and physical torture to the patients, have long-term sustained negative effects on families society. The attention neurological is increasing, improvement of material level accompanied by an increase in demand for level. p75 neurotrophin receptor (p75NTR) a low-affinity involved diverse pleiotropic developmental adult central nervous system (CNS). Since are usually regression memory, pathogenesis p75NTR also activates inhibits other signaling...
Abstract The abnormalities in static brain activity patients with post-stroke depression (PSD) have been widely reported. However, the dynamics of neural PSD remain enigmatic. We investigated dynamic amplitude low-frequency fluctuation (dALFF) method. Imaging and clinical data from 25 28 without collected April 2020 to June 2023 were evaluated. between-group comparisons dALFF variance state properties conducted using a combined approach sliding window clustering analysis. correlation...
<title>Abstract</title> Background Having psoriasis in hard-to-treat areas, such as the scalp, face, palms, soles, nails, and genitals, can suffer from a reduced quality of life. This study was designed to investigate prevalence risk factors body locations psoriasis, describe patients’ clinical demographic characteristics, life impacts. Methods We conducted multicenter observational epidemiological involving over 1000 hospitals China, enrolling total 7032 patients. Groups were compared...
Objective: To investigate the effects of angiotensin II type 1 receptor antagonist valsartan on leptin, leptin and collagen in rats with hepatic fibrosis. Methods: Thirty-six male wistar were randomly divided into control group, model group drug-treated 12 each group. Liver fibrosis models made by subcutaneous injection carbon tetrachloride dorsal rats, simultaneously gastric gavage Valsartan killed at end 8th week. The degree liver was observed HE Masson staining. serum (LP) TGFβ1...