A5039636294- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Regulation of Appetite and Obesity
- Peroxisome Proliferator-Activated Receptors
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Atherosclerosis and Cardiovascular Diseases
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Uterine Myomas and Treatments
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Nanoplatforms for cancer theranostics
- Prenatal Screening and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Sex and Gender in Healthcare
- Toxin Mechanisms and Immunotoxins
- Cholesterol and Lipid Metabolism
- Click Chemistry and Applications
- Chronic Myeloid Leukemia Treatments
University of Ottawa
2013-2025
Ottawa Hospital
2012-2024
Canadian Electricity Association
2022-2023
Ottawa Hospital Research Institute
2012-2022
Stanford University
2022
The Scarborough Hospital
2019
Isfahan University of Medical Sciences
2009
Pasteur Institute of Iran
2007
Inflammation impairs macrophage cholesterol clearance from vascular tissues and promotes atherosclerosis. Inflammatory macrophages suppress expression of the transcription cofactor interferon regulatory factor 2-binding protein 2 (IRF2BP2), genetic variants near IRF2BP2 associate with ischemic heart disease progression in humans.To test whether affects atherosclerosis mice humans.We generated that delete macrophages. IRF2BP2-deficient worsened irradiated low-density lipoprotein receptor...
Wolffian tumor and its nosologic relative, the recently defined STK11 adnexal are rare neoplasms thought to arise from mesonephric remnants. These tumors typically in broad ligament, fallopian tube, ovarian hilum although most associated with a good prognosis, up 50% of demonstrate aggressive clinical behavior. The chief differential diagnoses include endometrioid adenocarcinoma sex cord stromal tumors. However, morphologic immunohistochemical features these exhibit considerable overlap...
PTEN immunohistochemistry (IHC) is considered complimentary for assessment of abnormality in endometrial carcinoma (EC), since IHC staining pattern does not entirely correlate with the presence and absence mutations on sequencing. A set functionally defective variants stable protein levels are known to act a dominant-negative manner suppress wild-type activity. Our objective was evaluate patterns ECs (DN) mutations. next-generation sequencing (NGS, using Oncomine Comprehensive Assay v3) over...
Identification of ultramutated/ POLE -mutated endometrial carcinomas ( M ECs) has important implications given its association with better prognosis. However, mutation testing is not widely available. Our objective was to evaluate ECs versus wild-type WT ) ECs, within a cohort consultation cases features suggestive an ultramutated phenotype. Consultation EC that had undergone hotspot over 3.5-year period were included. Tumor morphology and immunohistochemistry reviewed for both groups....
The dramatic increase in the prevalence of obesity reflects a lack progress combating one most serious health problems this century. Recent studies have improved our understanding appetitive network by focusing on paraventricular hypothalamus (PVH), key region responsible for homeostatic balance food intake. Here we show that mice with PVH-specific ablation LIM domain only 4 ( Lmo4 ) become rapidly obese when fed regular chow due to hyperphagia rather than reduced energy expenditure. Brain...
Abstract Background Neuroendocrine (NE) differentiation is widely studied in non-small cell lung carcinomas (NSCLC) however, its significance remains unclear basaloid squamous (B-SqCC). This study aims to assess the extent of NE B-SqCC and characterize underlying molecular process. Methods evaluated resected B-SqCC, small cancer (SCLC) poorly differentiated SqCC (PD-SqCC) from 2005 2020 at Ottawa Hospital. Samples were subject pathological review, immunohistochemistry (IHC) survival...
Inhibitors of Apoptosis (IAP) family play a critical role in apoptosis and inflammatory response. Neuronal Inhibitory Protein (NAIP), as member both IAPs NLR families (NOD-Like Receptor), is unique IAP harboring NOD (Nucleotide Oligomerization Domain) LLR (Leucine Rich Repeat) motifs. Considering these motifs NAIP, it has been suggested that the main function NAIP distinct from other members IAPs. As NLR, mediates assembly 'Inflammasome' for caspase activation. Pathologic expression reported...
Our objective was to evaluate the diagnostic utility of 2 new proliferation markers, cyclin D1 and minichromosome maintenance complex component (MCM2), in comparison with p16, p53, Ki67 differentiating spectrum smooth muscle tumors. An institutional database search from 2009 2017 identified 10 cases uterine leiomyoma bizarre nuclei (LBN), 12 tumors uncertain malignant potential, 13 leiomyosarcomas (LMS). Ten resected leiomyomas (LM) were included as controls. Immunohistochemistry performed...
Our objective was to correlate cytomorphological features of metastatic non-small cell lung carcinoma (mNSCLC) with maximal standardized uptake value (mSUV) positron emission tomography (PET) in Lymph nodes (LNs).Positive cytology slides 114 LNs were reviewed from 100 patients mNSCLC who had undergone PET study. Student's t-test used for statistical comparisons.Mean patients' age: 68.5, 54% male. locations were: mediastinum: 99, hilum: 13, peribronchial: 1, axilla: 1. Final diagnoses...
573 Background: Most breast cancers are considered immunological cold and therefore minimally responsive to immunotherapies. Local cytotoxic therapies can induce cell death, expose tumor antigens, provide adjuvants for anti-tumor immune priming, potentially increase responsiveness We conducted a randomized, double blind, Phase 2 presurgical Window-Of-Opportunity trial intratumoral (IT) INT230-6 (comprising VINblastine (VIN) Cisplatin (VIN)) evaluating clinical BioLogical Effects in patients...
Abstract Background: Larger tumors pose an increased risk for breast cancer (BC) recurrence post-surgery. In addition, most BC outside of the triple negative subtype are considered immunological quiescent and minimally responsive to immunotherapies. One potential method combat disease induce immune activation pre-surgery is through a local therapy that could cause cell death expose tumor antigens, provide adjuvants anti-tumor priming, thus potentially increase responsiveness immunotherapies...
Interferon regulatory factor 2 binding protein (Irf2bp2), a co-repressor of Irf2, is required for fetal hepatic erythropoiesis through the expansion erythromyeloid progenitors. Mice with germline ablation entire Irf2bp2 transcript produced no viable Irf2bp2-null pups in first litters. In subsequent litters, fewer than 1/3 expected were born and half survived to adulthood. As humans somatic mutations IRF2BP2, adult mice developed lymphoma. Transcriptome profiling liver, heart, skeletal muscle...
The interobserver reproducibility is poor for histotyping within the p53-abnormal molecular category of endometrial carcinomas (ECs); therefore, biomarkers that improve histologic classification are useful. β-catenin has been proposed to have prognostic significance in specific clinicopathologic and contexts. diagnostic utility expression patterns determining histotype ECs not well studied. We identified molecularly classified as "p53-abnormal." was assigned when (1) no POLE exonuclease...
Introduction: Genetic variants near the gene encoding transcription cofactor Interferon Regulatory Factor 2 Binding Protein (IRF2BP2) have been tied to ischemic heart disease progression and elevated serum cholesterol. Expression of IRF2BP2 is suppressed in inflammatory macrophages, but significance this down-regulation was not known. Hypothesis: This study sought determine function macrophages its effect on atherosclerosis mice humans. Methods Results: We generated that delete...