A5011239558- Antibiotic Resistance in Bacteria
- Congenital Heart Disease Studies
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Congenital heart defects research
- RNA Research and Splicing
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Burn Injury Management and Outcomes
- Marine and fisheries research
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Colorectal and Anal Carcinomas
- Down syndrome and intellectual disability research
- Echinoderm biology and ecology
- Parathyroid Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Marine Bivalve and Aquaculture Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Protein Tyrosine Phosphatases
- Essential Oils and Antimicrobial Activity
- Tracheal and airway disorders
- Prenatal Screening and Diagnostics
- Ubiquitin and proteasome pathways
University of Ottawa
2020-2024
Institute of Infection and Immunity
2022
Kurdistan University of Medical Sciences
2011-2018
Chabahar Maritime University
2015-2018
Jahrom University of Medical Sciences
2012
Islamic Azad University, Tehran
2012
Tehran University of Medical Sciences
2011-2012
Alborz University of Medical Sciences
2012
Shahid Chamran University of Ahvaz
2010
Background The aetiological role of Human Papillomavirus (HPV) in oesophageal squamous cell carcinoma (ESCC) was evaluated by assessment the presence and status HPV DNA a Kurdish population west Iran. Methods One hundred three paraffin-embedded ESCC tissue samples, diagnosed between 2007-2013, were included study. extracted then genotypes determined PCR INNO-LiPA genotyping, respectively. Results detected 11/103 (10.7%) ESCCs. HPV-18 HPV-16 five six Co-infection HPV-6 only found with two...
Treatment of infectious diseases is becoming more challenging with each passing year. This especially true for infections caused by Pseudomonas aeruginosa, an opportunistic pathogen the ability to rapidly develop resistance multiple classes antibiotics.This study was conducted determine prevalence metallo-β-lactamase (MBL)-producing strains among multidrug-resistant P. aeruginosa isolated from burn patients.The isolates were identified, tested susceptibility various antimicrobial agents, and...
Background The mutations in GATA4 gene induce inherited atrial and ventricular septation defects, which is the most frequent forms of congenital heart defects (CHDs) constituting about half all cases. Method We have performed High resolution melting (HRM) mutation scanning coding exons nonsyndrome 100 patients as a case group including 39 septal (ASD), 57 (VSD) four with both above 50 healthy individuals control group. Our samples are categorized according to their HRM graph. genome...
During the study period, 145 burn patients were admitted to unit of Tohid Hospital. Their mean age and total body surface area (TBSA) 29 years 37.7 %, respectively. The length hospital stay was 10 days. Kerosene most com-mon cause burns (60 %), followed by gas (30 %). In 176 clinical specimens from patients, 100
Interferon regulatory factor 2 binding protein (IRF2BP2) suppresses the innate inflammatory response of macrophages. A 9-nucleotide deletion (rs3045215) in 3' untranslated region (3'-UTR) human IRF2BP2 mRNA confers risk coronary artery disease (CAD) Ottawa Heart Genomics Study (OHGS). Here, we sought to identify mechanisms that may contribute this risk. We tested how lipopolysaccharides (LPS) affects expression THP-1 macrophages and primary aortic smooth muscle cells (HAoSMC) genotyped for...
Background: Congenital heart diseases (CHD) are the most common of all birth defects, affecting nearly 0.9% live births. Nkx2-5 mutations were reported to cause CHD but data in Kurdish populations Iran limited. Objectives: In this experimental study, we performed high resolution melt (HRM) mutation scanning exons non-syndrome patients. Patients and Methods: Thirty nine patients with atrial septal defect 57 ventricular defect, 4 possessing both defects as case groups 50 healthy controls. Then...
Background: In cervical cancer, the carcinogenic mechanism of human papillomavirus (HPV) occurs through integration viral DNA into host genome. This process initiates with a disruption in E2 open reading frame (ORF) Disruption ORF results an increased expression oncoproteins, E6 and E7, by removal suppression effect on their promoters. E7 interfere normal cell cycle degrading p53 pRb tumor suppressor proteins, respectively. Objectives: The objective this study was to determine physical...
Interferon regulatory factor 2 binding protein (Irf2bp2), a co-repressor of Irf2, is required for fetal hepatic erythropoiesis through the expansion erythromyeloid progenitors. Mice with germline ablation entire Irf2bp2 transcript produced no viable Irf2bp2-null pups in first litters. In subsequent litters, fewer than 1/3 expected were born and half survived to adulthood. As humans somatic mutations IRF2BP2, adult mice developed lymphoma. Transcriptome profiling liver, heart, skeletal muscle...
Background: Arterial calcification often occurs with bone mineral loss in osteoporosis, for which bisphosphonates are a standard therapy. Mice lacking the matrix GLA protein (Mgp) exhibit lethal arterial and cranial formation deficits causing dental malocclusion. Mgp not only binds to hydroxyapatite but also inhibits morphogenic activation of Runx2 transcription factor, drives osteogenic conversion smooth muscle cells (SMCs). Prior studies showed bisphosphate therapy ameliorates...
Background: Genetic variants on chromosome 9 at p21.3 confer a heightened risk of atherosclerosis and coronary artery calcification. The 9p21.3 cause the selective expression non-coding RNA transcripts (ANRIL) that regulate many genes through ALU element mediated silencing. However, to date, none these regulated account for effect Methods Results: To identify differentially by variants, primary human aortic smooth muscle cells (HAoSMCs) from 11 different donors genotyped (n=3-4/genotype)...
: Background: Treatment of infectious diseases is becoming more challenging with each passing year. This especially true for infections caused by Pseudomonas aeruginosa, an opportunistic pathogen the ability to rapidly develop resistance multiple classes antibiotics. Objectives: study was conducted determine prevalence metallo-β-lactamase (MBL)–producing strains among multidrug-resistant P. aeruginosa isolated from burn patients. Materials and Methods: The isolates were identified, tested...
: Background: Treatment of infectious diseases is becoming more challenging with each passing year. This especially true for infections caused by Pseudomonas aeruginosa, an opportunistic pathogen the ability to rapidly develop resistance multiple classes antibiotics. Objectives: study was conducted determine prevalence metallo-β-lactamase (MBL)–producing strains among multidrug-resistant P. aeruginosa isolated from burn patients. Materials and Methods: The isolates were identified, tested...
The TBX5 transcription factor plays an important role during morphogenesis and development of the heart. Mutations in this gene often lead to Holt-Oram syndrome (HOS). This study identified mutations patients with non-syndromic congenital heart defects (CHD). Screening for CHD, including 100 a septal defect 50 healthy subjects as controls were performed by technique high-resolution melt (HRM). Exons sequenced samples that showed HRM curve differences compared controls. Structural stability...