A5027325514- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Air Quality and Health Impacts
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Metabolism and Genetic Disorders
- Plant Gene Expression Analysis
- Atmospheric chemistry and aerosols
- Chromosomal and Genetic Variations
- Insect Resistance and Genetics
- Autism Spectrum Disorder Research
- Cancer, Hypoxia, and Metabolism
- Plant Molecular Biology Research
- Traditional Chinese Medicine Analysis
- Plant-Microbe Interactions and Immunity
- Plant tissue culture and regeneration
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Plant biochemistry and biosynthesis
State Grid Corporation of China (China)
2025
State Grid Shanxi Electric Power Company Electric Power Research Institute
2025
Chinese Academy of Sciences
2009-2025
Zhengzhou University
2024-2025
Jilin Province Tumor Hospital
2022-2025
Shanghai Institute of Materia Medica
2023-2025
Nanjing University of Chinese Medicine
2023-2025
Yunnan University
2019-2024
Wuhan University
2020-2024
Nankai University
2022-2024
We have previously shown that serum insulin levels decrease threefold and blood glucose remain normal in mice fed a leucine-deficient diet, suggesting increased sensitivity. The goal of the current study is to investigate this possibility elucidate underlying cellular mechanisms.Changes metabolic parameters expression genes proteins involved regulation sensitivity were analyzed mice, human HepG2 cells, mouse primary hepatocytes under leucine deprivation.We show deprivation improves hepatic...
Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel adenine modification, N(6)-methyladenine (6mA), has recently been found cells. However, presence function(s) of 6mA brain remain unclear. Here we demonstrate dynamics mouse response to environmental stress. We find that overall levels are significantly elevated upon Genome-wide transcriptome profiling reveal an inverse association between dynamic...
OBJECTIVE White adipose tissue (WAT) and brown (BAT) play distinct roles in adaptation to changes nutrient availability, with WAT serving as an energy store BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet unexpectedly experienced dramatic reduction abdominal fat mass. The cellular mechanisms responsible for this loss, however, are unclear. goal of current study is investigate possible mechanisms. RESEARCH DESIGN AND METHODS Male C57BL/6J...
Abstract Emerging evidence suggests that active DNA demethylation machinery plays important epigenetic roles in mammalian adult neurogenesis; however, the precise molecular mechanisms and critical functional players of this process remain largely unexplored. Ten–eleven translocation (Tet) proteins convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) its downstream derivatives. Here we show 5hmC is elevated during differentiation neural stem cells (aNSCs), Tet2 primarily...
Abstract Maternal RNA degradation is critical for embryogenesis and tightly controlled by maternal RNA-binding proteins. Fragile X mental-retardation protein (FMR1) binds target mRNAs to form ribonucleoprotein (RNP) complexes/granules that control various biological processes, including early embryogenesis. However, how FMR1 recognizes FMR1-RNP granule assembly/disassembly regulates FMR1-associated remain elusive. Here we show Drosophila preferentially containing m6A-marked “AGACU” motif...
Whole-genome duplication events (polyploidy events) and gene loss have played important roles in the evolution of legumes. Here we show that vast majority Hsf duplications resulted from whole genome rather than tandem duplication, significant differences retention exist between species. By searching for intraspecies colinearity (microsynteny) dating age distributions duplicated genes, found accounted 42 46 Hsf-containing segments Glycine max, while paired were rarely identified Lotus...
5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC its writers, ten-eleven translocation (Tet) proteins, stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-like behavior mice resulted a reduction prefrontal cortex (PFC). We found loss Tet1 (Tet1 KO) led resistance CRS, whereas Tet2 (Tet2 increased susceptibility CRS. Genome-wide profiling...
Abstract Long noncoding RNAs (lncRNAs) are regarded as crucial regulators in tumor progression. Potassium two pore domain channel subfamily K member 15 and WISP2 antisense RNA 1 (KCNK15-AS1) has been confirmed to inhibit the migration invasion of pancreatic cancer (PC) cells. However, its downstream mechanism effect on other cellular functions PC remain unknown. This study probed function potential KCNK15-AS1 cell growth. RT-qPCR western blot were employed measure gene expression ISH was...
AGO/miRNA-mediated gene silencing and ubiquitin-mediated protein quality control represent two fundamental mechanisms that proper expression. Here, we unexpectedly discover fly human AGO proteins, which are key components in the miRNA pathway, undergo lipid-mediated phase separation condense into RNP granules on endoplasmic reticulum (ER) membrane to production. Phase ER is mediated by electrostatic interactions between a conserved lipid-binding motif within AGOs lipid PI(4,5)P2. The...
The honeybee (Apis mellifera) is a well-known eusocial insect. In colonies, thousands of sterile workers, including nurse and forager bees, perform various tasks within or outside the hive, respectively. queen only fertile female responsible for reproduction. workers share similar genomes but occupy different caste statuses. We established single-cell transcriptomic atlases brains from queens worker subcastes identified five major cell groups: Kenyon, optic lobe, olfactory projection, glial,...
Evidence suggests that probiotic interventions reduce non-communicable diseases (NCDs) risk. However, its therapeutic effect and mechanism are still unclear. To evaluate the hypocholesterolemic of Lactobacillus plantarum H6 (L.p H6), a new commercial patent strain capable preventing hypercholesterolemia, in depth, three states were prepared, namely, viable (vH6), heat-inactivated (iH6), ultrasonically-lysed (uH6) bacteria cells. The results showed v/i/uH6 cells could lower serum liver blood...
Microglia are versatile regulators in brain development and disorders. Emerging evidence links microRNA (miRNA)-mediated regulation to microglial function; however, the exact underlying mechanism remains largely unknown. Here, we uncover enrichment of miR-137, a neuropsychiatric-disorder-associated miRNA, nucleus, reveal its unexpected nuclear functions maintaining global transcriptomic state, phagocytosis, inflammatory response. Mechanistically, Mir137 deletion increases chromatin...