A5100370292- Adipose Tissue and Metabolism
- Obstructive Sleep Apnea Research
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- Opioid Use Disorder Treatment
- Regulation of Appetite and Obesity
- Fungal Biology and Applications
- Pharmacology and Obesity Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Sleep and related disorders
- Alzheimer's disease research and treatments
- Alcoholism and Thiamine Deficiency
- Venous Thromboembolism Diagnosis and Management
- Neuroscience of respiration and sleep
- Acupuncture Treatment Research Studies
- Treatment of Major Depression
- Cardiovascular Disease and Adiposity
- Acute Ischemic Stroke Management
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
UK Dementia Research Institute
2024-2025
University of Cambridge
2024-2025
University of Pennsylvania
2022-2025
Shanghai Jiao Tong University
2017-2025
Xiamen University
2012-2025
Xian Central Hospital
2025
Xi'an Jiaotong University
2025
Yan'an University
2025
Yichang Central People's Hospital
2025
China Three Gorges University
2025
Irisin, a 112-amino acid peptide induced with exercise in mice and human is thought to have correlation the short-term outcomes of patients ischemic stroke. In present study, neuroprotective effects irisin were evaluated vivo vitro its underlying mechanism was also explored. The global cerebral ischemia/reperfusion (I/R) model established by bilateral common carotid artery occlusion for 20 min reperfusion 24 h oxygen-glucose deprivation/reperfusion HT22 cells. Neurological function scored...
Intuitively, how you feel about potential outcomes will determine your decisions. Indeed, an implicit assumption in one of the most influential theories psychology, prospect theory, is that feelings govern choice. Surprisingly, however, very little known rules by which are transformed into Here, we specified a computational model used to predict choices. We found this predicted choice better than existing value-based models, showing unique contribution decisions, over and above value....
Abstract Ulcerative colitis (UC) is an idiopathic, chronic inflammatory condition of the colon, characterized by repeated attacks, a lack effective treatment options, and significant physical mental health complications for patients. The endoplasmic reticulum (ER) vital intracellular organelle in maintaining cellular homeostasis. Endoplasmic stress (ERS) induced when body exposed to adverse external stimuli. Numerous studies have shown that ERS-induced apoptosis plays role pathogenesis UC....
ABSTRACT Histone acetylation, regulated by the opposing actions of histone acetyltransferases (HATs) and deacetylases, is an important epigenetic mechanism in eukaryotic transcription. Although acetyltransferase (PfGCN5) has been shown to preferentially acetylate H3 at K9 K14 Plasmodium falciparum , scale acetylation parasite genome its role transcriptional activation are essentially unknown. Using chromatin immunoprecipitation (ChIP) DNA microarray, we mapped global distribution PfGCN5,...
Abstract Objective To investigate whether irisin could protect against blood–brain barrier (BBB) dysfunction following focal cerebral ischemia/reperfusion in rats. Methods and Materials Seventy‐two adult male Sprague Dawley rats weighing 280–320 g were randomly divided into three groups: sham operation group (S), (FC), (IR). Focal ischemia was induced by improved thread occlusion of right middle artery (MCAO) for 2 hr followed reperfusion 24 After reperfusion, the neurological evaluation...
Amphotericin-like glycosylated polyene macrolides (GPMs) are a clinically and industrially important family of natural products, but the mechanisms by which they exert their extraordinary biological activities have remained unclear for more than half century. Amphotericin B exerts fungicidal action primarily via self-assembly into an extramembranous sponge that rapidly extracts ergosterol from fungal membranes, it has whether this mechanism is applicable to other GPMs. Using highly conserved...
Previous studies have reported the effects of obstructive sleep apnea (OSA) and cardiometabolic disorders on cardiovascular disease (CVD), but associations between biomarkers two cardinal features OSA (chronic intermittent hypoxia fragmentation) their interactions CVD in populations remain unclear. A total 1727 subjects were included this observational study. Data overnight polysomnography parameters, biochemical biomarkers, anthropometric measurements collected. Metabolic syndrome (MS),...
The AAA + -ATPase valosin-containing protein (VCP; also called p97 or Cdc48), a major unfolding machinery with variety of essential functions, localizes to different subcellular compartments where it has functions. However, the processes regulating distribution VCP between cytosol and nucleus are not understood. Here, we identified p37 (also UBXN2B) as factor nucleocytoplasmic shuttling. p37-dependent localization was crucial for local cytosolic such autophagy, nuclear functions in DNA...
Background and Aims: Internet gaming disorder (IGD), as a relapse disease, has become common mental health problem among Asian teenagers. Functional connections in the prefrontal lobo-striatum affect changes impulsivity inhibition. Therefore, exploration of directional relevant brain regions prefrontal-striatal circuit synchronization level two hemispheres will help us to further understand neural mechanism IGD, which can provide guidance for development prevention intervention strategies....
The prevalence of lymphedema is rising, necessitating accurate diagnostic and treatment information for affected patients. Short video-sharing platforms facilitate access to such but require validation regarding the reliability quality content presented. This study aimed assess lymphedema-related on Chinese short platforms. We collected 111 video samples addressing diagnosis from four platforms: TikTok, Bilibili, WeChat, Microblog. Two independent surgeons evaluated each comprehensiveness,...
Abstract Background Opioid use disorder (OUD) has been linked to macroscopic structural alterations in the brain [1]. The monthly injectable, extended-release formulation of μ-opioid antagonist naltrexone (XR-NTX) is highly effective reducing opioid craving and preventing relapse [2,3]. Aims & Objectives We aimed investigate neuroanatomical effects XR-NTX by examining changes cortical thickness during treatment for OUD. Method Forty-seven OUD patients underwent magnetic resonance imaging...
Advanced heart failure in patients with valvular atrial fibrillation (VAF) poses a significant threat to human health. Noninvasive assessment of left remodeling various pathological conditions is instrumental guiding clinical treatment decisions, evaluating efficacy, and predicting prognosis. The study enrolled 63 diagnosed mitral stenosis (MS), among whom 44 presented concomitant (AF) 19 had sinus rhythm. Left volume functional parameters were evaluated using real-time three-dimensional...
Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy has demonstrated promising potential for treating metastatic castration-resistant prostate cancer. Recently, albumin-binding motif-modified PSMA radioligands with prolonged blood circulation were developed to improve tumor uptake and therapeutic effectiveness, properties which, however, associated an increased risk of bone marrow toxicity. This study presents new PSMA-targeted incorporating dansylated amino acids...
To investigate the effect of atrial fibrillation (AF) on risk for new-onset chronic kidney disease (CKD) and all-cause mortality in a sample Chinese population. A total 1,432 patients with AF were propensity matched (1 : 4) 5,722 individuals without (non-AF group). Clinical endpoints included CKD or mortality. The cumulative incidence two groups was compared using Kaplan-Meier curve analysis. association between assessed Cox proportional hazards model. During 5.9-year follow-up, 190 641...
<title>Abstract</title> Background Although numerous studies have demonstrated the positive relationships between apnea-hypopnea index (AHI), micro-arousal (MAI) and glucose metabolism, associations sleep fragmentation during REM-phase NREM-phase abnormal metabolism is not clear yet. Methods Subjects with initially suspected obstructive apnea (OSA) in Shanghai Sleep Health Study (SSHS) were selected. For each subject, MAI-REM MAI-NREM data from overnight standard polysomnography; fasting...
Obstructive sleep apnea (OSA) is thought to be associated with dyslipidemia. However, differences concerning dyslipidemia during rapid eye movement (REM) and non-REM (NREM) have yet determined. This study was designed explore the association between lipid profiles OSA REM or NREM sleep. a clinical cohort. A total of 2,619 participants at least 30 minutes were included. Sleep variables fasting [total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), high-density (HDL-C),...
Abstract Background Previous preclinical and human studies have shown that a high-fat ketogenic diet ketone supplements (KS) are efficacious in reducing alcohol craving, consumption, signs of withdrawal. However, the effects KS on sensitivity unknown. Methods In this single-blind, cross-over study, 10 healthy participants (3 females) were administered single, oral dose (25 g ketones from D-β-hydroxybutyric acid R-1,3-butanediol) or placebo 30 minutes before an (0.25 g/kg for women; 0.31...