A5069135453- Smoking Behavior and Cessation
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Biochemical Analysis and Sensing Techniques
- Treatment of Major Depression
- Neonatal Respiratory Health Research
- Inflammation biomarkers and pathways
- Advanced Neuroimaging Techniques and Applications
- Regulation of Appetite and Obesity
- Endometrial and Cervical Cancer Treatments
- Hepatitis C virus research
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Neural and Behavioral Psychology Studies
- Acupuncture Treatment Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Maternal Mental Health During Pregnancy and Postpartum
- Hormonal Regulation and Hypertension
- Pharmacological Effects of Natural Compounds
- Cognitive Abilities and Testing
- Phytochemical Studies and Bioactivities
- Lung Cancer Diagnosis and Treatment
- Evaluation and Optimization Models
University of Pennsylvania
2015-2025
Fujian Medical University
2024
Fujian Provincial Hospital
2024
California University of Pennsylvania
2018-2022
Nanjing University of Chinese Medicine
2019-2021
Lanzhou University
2021
Lanzhou University Second Hospital
2021
Nanjing Medical University
2021
Tongji University
2020
Shanghai Pulmonary Hospital
2020
Abstract Background Opioid use disorder (OUD) has been linked to macroscopic structural alterations in the brain [1]. The monthly injectable, extended-release formulation of μ-opioid antagonist naltrexone (XR-NTX) is highly effective reducing opioid craving and preventing relapse [2,3]. Aims & Objectives We aimed investigate neuroanatomical effects XR-NTX by examining changes cortical thickness during treatment for OUD. Method Forty-seven OUD patients underwent magnetic resonance imaging...
In smokers, neural responses to smoking cues can be sensitive acute abstinence, but the degree which abstinence-related cue reactivity contributes relapse is not fully understood. This study addressed this question in a sample of 75 smokers who were motivated quit smoking. Participants underwent blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) during presentation visual and neutral stimuli on two occasions: once satiety following 24-hour abstinence (order...
To explore a precise association between tumor location and lymph node (LN) biopsy algorithm in uterine confined endometrial cancer (EC). Patients with EC treated the Department of Obstetrics Gynecology, South Branch Fujian Provincial Hospital were included this observational retrospective study. Based on procedure treatment, patients separated to stage I (2015.07–2019.09) II (2019.09–2021.9). In each stage, high low-risk group by predicted results. high-risk received systematic...
Purpose To determine whole‐brain cerebral metabolic rate of oxygen (CMRO 2 ), an improved imaging approach, based on radial encoding, termed OxFlow (rOxFlow), was developed to simultaneously quantify draining vein venous saturation (SvO ) and total blood flow (tCBF). Methods evaluate the efficiency precision rOxFlow sequence, 10 subjects were studied during a paradigm repeated breath‐holds with both Cartesian (cOxFlow) sequences. CMRO calculated at baseline from OxFlow‐measured data assuming...
Subjective stress is a well-documented predictor of early smoking relapse, yet our understanding and tobacco use limited by reliance on self-reported measures stress. We utilized validated functional neuroimaging paradigm to examine whether exposure during abstinence alters objective brain function.Seventy-five participants underwent blood oxygen level dependent (BOLD) magnetic resonance imaging (fMRI) the Montreal Imaging Stress Task (MIST) two occasions: once satiety following...
Although exogenous progesterone may hold promise as a treatment for nicotine use disorders, it is unclear whether similarly effective in males and females. This study examined the effects of on disorder comprehensively using behavioral, psychological, neural measures male female smokers exposed to brief abstinence.Thirty-three 33 non-treatment-seeking participated double-blind, randomized, placebo-controlled crossover 200 mg or placebo daily over four-day abstinence period. Smoking behavior...
Background It is not known whether behavioral weight loss can attenuate blood oxygen level-dependent responses to food stimuli. Objectives This randomized controlled trial assessed the effects of a commercially available program (WW, WeightWatchers) compared wait-list control on response cues. Methods Females with obesity ( N = 61) were or control. At baseline and follow-up, participants completed assessments that included functional magnetic resonance imaging scans assess images...
Progesterone administration has therapeutic effects in tobacco use disorder (TUD), with females benefiting more than males. Conversion of progesterone to the neurosteroid allopregnanolone is hypothesized partly underlie progesterone; however, this not been investigated clinically. Smokers (n = 18 males, n 21 females) participated a randomized, double-blind, placebo-controlled crossover study 200 mg daily across 4 days abstinence. The ratio allopregnanolone:progesterone was analyzed...
To compare the clinical effect of wrist-ankle needle combined with opioid drugs and alone in treating refractory cancer pain.Sixty patients were randomly divided into an observation group a control group, 30 cases each one. The accordance three-step analgesic principle other auxiliary treated group. On basis treatment was added acupoints selected according to pain site primary focus, given once day for 10 days. visual analogue scale (VAS) score, times outbreaks incidence adverse reactions...
Taking fresh agricultral products sale logistics systems as research object, this paper established an index system for the risk evaluation of products. In determining weight index, calculation is combined with AHP and entropy method, we evaluated safety using Fuzzy comprehensive evaluation.
To investigate the effects of Yiqi Huayu Hutan decoction on pulmonary fibrosis rats which induced by bleomycin.The rat model was intratracheal injection bleomycin hydrochloride (5 mg/kg). Sixty SD were randomly divided into normal group (group N), M), positive control Y), low concentration LC), medium MC) and high HC). After 4 weeks, experimental groups treated with decoction, respectively, Y hydrocortisone acetate, Group N M saline intragastric administration. Twelve weeks later, killed...
Abstract The present study was aimed to explore the protective role of isoacteoside (ISO) in cecal ligation and puncture (CLP)-induced acute lung injury (ALI) mice. Mice were divided into following groups: sham control group, ALI ALI+ISO which mice received 10,50 or 100 mg/kg/day ISO for 3 days before, 0h 12h after CLP surgery. In first experiment, all maintained until 72 h operation calculate survival rate. second mouse serum bronchoalveolar lavage fluid (BALF) collected 24 model...
Objective: The immune system is involved in the pathogenesis of schizophrenia; here, we aimed to explore relationship cytotoxic T lymphocyte antigen 4 ( CTLA4 ) with schizophrenia. Methods: gene structure was first analyzed, and then rs231779, rs733618, rs231775 rs3087243 were selected as tag single nucleotide polymorphisms for linkage disequilibrium blocks Chinese Han population study expression quantitative trait loci normal brain tissue. Additionally, membrane mCTLA4 soluble sCTLA4 mRNA...
Abstract Background: Stimulator of IFN genes (STING) is highly expressed in the livers non-alcoholic fatty liver disease(NAFLD) patients and HFD induced NAFLD mice model. The STING signaling inflammation has been shown to be a critical role metabolic disorders, such as Type 2 diabetes. Lingguizhugan decoction (LGZG), Traditional Chinese herbal decoction, applied treat disorders for many years. However, whether LGZG can alleviate progression through inhibiting not fully understood. This study...
Tuberculosis (TB) is still one of the most serious infectious diseases in world.With increase Mycobacterium tuberculosis (MTB) resistance to first-line anti-TB drugs, second-line drugs such as fluoroquinolones, aminoglycosides and thioamides are given more attention clinical applications.As MTB mechanism has become a hotspot for many scholars.There some common resistant mechanisms drug by gene mutations, changes cell wall structure permeability efflux pump other mechanisms, but there...