A5101710499- Enhanced Recovery After Surgery
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Gastrointestinal motility and disorders
- Cerebrospinal fluid and hydrocephalus
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Botanical Studies and Applications
- Gastrointestinal Tumor Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Chronic Kidney Disease and Diabetes
- thermodynamics and calorimetric analyses
- Marine Sponges and Natural Products
- Tracheal and airway disorders
- Intestinal and Peritoneal Adhesions
- Gut microbiota and health
- Acute Kidney Injury Research
- Neutropenia and Cancer Infections
- Cardiac Valve Diseases and Treatments
- Autophagy in Disease and Therapy
- Cynara cardunculus studies
- Parasitic Diseases Research and Treatment
- Blood transfusion and management
- Nematode management and characterization studies
Botswana Geoscience Institute
2025
BGI Research
2025
Wuhan Third Hospital
2022-2023
Tongren Hospital
2022-2023
Cangzhou Central Hospital
2021-2022
First Affiliated Hospital of Bengbu Medical College
2019-2022
Chinese People's Liberation Army
2022
174th hospital of the People's Liberation Army
2022
Beijing University of Chemical Technology
2021
Nanjing Agricultural University
2021
Marine natural products are promising sources for drug discovery due to their unique structures and diverse biological activities. The establishment of the Global Microbiome Genome Catalogue (GOMC) has significantly expanded repository derived from marine-associated bacteria. In this study, we identified Class I lanthipeptide biosynthetic gene cluster col Colwellia_A sp. based on GOMC database. Through heterologous expression in Escherichia coli subsequent structural analysis, characterized...
Abstract Background Acute respiratory distress syndrome (ARDS) has been a prevalent disease in ICU with mortality of up to 27–45%. A considerable proportion extubated ARDS patients passing spontaneous breathing trial (SBT) still requires reintubation. Methods Lung ultrasonography (LUS) was used predict the success rate extubation. Ninety-two 60-min SBT were included this prospective research. Their clinical characters including LUS, APACHE II, SOFA, CPIS, EVLWI and PaO 2 /FiO collected...
<b><i>Background/Aims:</i></b> Risk factor studies for acute kidney injury (AKI) in China are lacking, especially those regarding non-traditional risk factors, such as laboratory indicators. <b><i>Methods:</i></b> All adult patients admitted to 38 tertiary and 22 secondary hospitals any one month between July December 2014 were surveyed. AKI screened according the Kidney Disease: Improving Global Outcomes’ definition of AKI. Logistic regression...
Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first-line treatment against advanced clear cell renal carcinoma (RCC), but resistance to therapy inevitable. Reactive oxygen species production associated with sensitivity chemotherapy, underlying mechanisms are not completely understood. Here, we investigated contributing Sun using RCC lines ACHN and 786-O. We report that Sun-resistant cells exhibited reduced apoptosis, increased...
Trichinellosis is a foodborne zoonotic disease caused by Trichinella spp., including spiralis. In the present study, T. spiralis membrane-associated progesterone receptor component-2 (Ts-MAPRC2) gene was cloned and characterized using protein sequencing analysis. Furthermore, expression, purification, immunoblot assay, binding ability with antibody, immunofluorescence assay were performed. A direct effect of (P4) mifepristone (RU486) on Ts-MAPRC2 determined in vitro cell culture that showed...
To explore the cause of early death (death within 3-12 months after hemodialysis) and related influencing factors patients undergoing maintenance hemodialysis (MHD) as to provide a scientific basis for prevention death.A retrospective matched controlled study was conducted. Fifty-one who underwent MHD from January 2004 April 2014 died in center 174th Chinese People's Liberation Army Hospital were included case group by analysis method. According 1:2 controls, 102 same period (±2 months)...
Clear cell renal carcinoma (ccRCC) is the most common type of cancers. However, circ_DENND1B has not been studied yet. GSE100186 dataset was used for level analysis circ_DENND1B. The quantitative real-time PCR to verify expression circ_DENND1B, microRNA-122-5p (miR-122-5p) and tissue inhibitor metalloproteinases-2 (TIMP2) in ccRCC tissues cells. Cell proliferation, migration, invasion apoptosis were detected by colony formation assay, thymidine analog 5-ethynyl-2'-deoxyuridine...
Objective To investigate the safety and clinical outcomes of early oral feeding after laparoscopic surgery colorectal cancer. Methods A randomized controlled trial was conducted from March 2012 to 2013 in Department Gastrointestinal Surgery, Xuzhou Hospital, Medical College Southeast University. A total 120 patients with cancer undergoing were randomly divided into group (60 cases) conventional cases). Clinical parameters, markers nutrition postoperative complications evaluated both...
The platinum-based chemotherapy play an important role in alleviating symptoms of advanced ovarian cancer patients and prolongation survival time ,The multidrug resistance(MDR),however,seriously affects the affect, current MDR its Mechanism studies show that,as a phase Ⅱ detoxification enzymes ghtathione S-transferase-π(GST-π) promote tumor cell resistance to chemotherapoutic drugs by affecting biotransformation metabolic processes drugs,and closely related cancer. Key words:...
Objective: The immune system is involved in the pathogenesis of schizophrenia; here, we aimed to explore relationship cytotoxic T lymphocyte antigen 4 ( CTLA4 ) with schizophrenia. Methods: gene structure was first analyzed, and then rs231779, rs733618, rs231775 rs3087243 were selected as tag single nucleotide polymorphisms for linkage disequilibrium blocks Chinese Han population study expression quantitative trait loci normal brain tissue. Additionally, membrane mCTLA4 soluble sCTLA4 mRNA...
Objective To investigate the metastasis rule and its clinical significance in pan-creatic capsule anterior layer of transverse mesocolon gastric cancer. Methods A total eighty specimens cancer were collected from June 2012 to January 2014 Department Gastroin-testinal Surgery, Xuzhou Hospital, Medical College Southeast University. The pancreatic histologically immunohistochemically analyzed for metas-tasis, analyze relationship with clinicopathologic characteristics...
Objective To find out the application of enteral nutrition in treatment functional delayed gastric emptying (FDGE) after operation constipation. Methods Eighty patients with severe constipation received laparoscopic assisted subtotal colectomy combined modified Duhamel procedure from July 2008 to March 2013 were retrospectively analyzed. The postoperative FDGE conservative support. Results Of 80 constipation, 13 had FDGE, incidence being 16.25%. Nine cases treated total and 4...
Objective To investigate the clinical outcomes of perioperative management guided by idea fast track surgery in colorectal cancer. Methods A controlled randomized trial was conducted from September 2011 to October 2012 department Gastrointestinal Surgery, Xuzhou Hospital, Medical College Southeast University.A total 100 patients with cancer who would undergo elective operation were randomly divided into two groups: a fast-track group(50 cases)and conventional treatment cases)....
To investigate the clinical features and principles of diagnosis treatment early postoperative inflammatory ileus (EPII). The data 69 patients with EPII treated in this hospital were retrospectively reviewed. mostly occurred 3-11d after abdominal surgery, average time was 5d. Sixty two cases cured a mean period (22±13)d through combination therapy including gastroenteral decompression, somatostatin, dexamethasone total parenteral nutrition (TPN). Seven by operation. is special type...
Objective To explore the relationship between different blood glucose levels and prognosis in patients with acute severe craniocerebral injury. Methods Clinical data of 120 injury from Jun. 2014 to 2017 Department Neurosurgery, Tongren Hospital Wuhan University were analyzed retrospectively. The divided into group extra-severe according Glasgow coma score (GCS) . Blood detected at time admission, 1st day, 3rd 7th day 14th after operation. According on normal group, value 6.1-10.0...