A5061994382- Smoking Behavior and Cessation
- Nicotinic Acetylcholine Receptors Study
- Behavioral Health and Interventions
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Obesity, Physical Activity, Diet
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Glioma Diagnosis and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Economic and Financial Impacts of Cancer
- Angiogenesis and VEGF in Cancer
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Advanced Biosensing Techniques and Applications
- BRCA gene mutations in cancer
- Advanced biosensing and bioanalysis techniques
- Mental Health Research Topics
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Digital Radiography and Breast Imaging
- COVID-19 and healthcare impacts
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine Tumor Research Advances
University of Pennsylvania
2016-2025
California University of Pennsylvania
2014-2022
Center for Clinical Research (United States)
2019-2020
VA Connecticut Healthcare System
2017
Philadelphia VA Medical Center
2017
Yale University
2013-2017
Abramson Cancer Center
2017
Sidney Kimmel Cancer Center
2017
Hospital of the University of Pennsylvania
2017
University of Pennsylvania Health System
2005-2016
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential component TME, contributing to tumorigenesis by secreting growth factors, modifying extracellular matrix, supporting angiogenesis, and suppressing antitumor immune responses. Through unbiased approach, we have established IL-6 mediates cross-talk...
Abstract Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. and other Notch receptor paralogs cooperate act as a tumor suppressor cell carcinomas (SCCs). However, can be stochastically activated promote carcinogenesis murine models of SCC. Activated form promotes xenograft growth when expressed ectopically. Here, we demonstrate that activation epithelial–mesenchymal transition (EMT) are coupled SCC initiation concert with transforming factor...
Nicotine is metabolized to cotinine, and cotinine 3'-hydroxycotinine (3-HC) by the liver enzyme cytochrome P450 (CYP) 2A6. More rapid metabolism of nicotine may result in lower blood levels from replacement products poorer smoking cessation outcomes. This study evaluated utility 3-HC/cotinine ratio as a predictor efficacy therapy an aid for cessation.By use open-label design, 480 treatment-seeking smokers were randomly assigned 8 weeks transdermal or nasal spray use, plus behavioral group...
Craving is a hallmark of drug dependence, including dependence on nicotine. Many studies have examined the neural substrates cravings elicited by smoking-related cues. Less known about basis unprovoked, abstinence-induced cravings, despite contributions such to smoking relapse. To fill this gap, we used arterial spin labeled (ASL) perfusion magnetic resonance imaging characterize smoke. Fifteen chronic smokers were scanned during resting state two separate occasions: (1) satiety and (2)...
Abstract Hypoxia is known to be an important prognostic marker in many human cancers. We report the use of two oxygen measurement techniques brain tumors and compare these data with semiquantitative histological end points. Oxygenation was measured using Eppendorf needle electrode and/or EF5 binding 28 tumors. These were compared necrosis, mitosis, endothelial proliferation. In some tumors, absolute converted tissue pO2 based on vitro calibrations. readings could not used identify WHO grade...
Blood tests to detect circulating tumor cells (CTC) offer great potential monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell surface biomarkers like epithelial adhesion molecules tumors tend lack. Here, we describe a strategy based telomerase activity, which is elevated in nearly all but normal cells. This uses an...
Evidence points to the endogenous opioid system, and mu-opioid receptor (MOR) in particular, mediating rewarding effects of drugs abuse, including nicotine. A single nucleotide polymorphism (SNP) human MOR gene (OPRM1 A118G) has been shown alter protein level preclinical models smoking behavior humans. To clarify underlying mechanisms for these associations, we conducted an vivo investigation OPRM1 A118G genotype on binding potential (BP(ND) or availability). Twenty-two smokers prescreened...
The US Food and Drug Administration adopted labeling for nicotine patches to allow use beyond the standard 8 weeks. This decision was based in part on data showing increased efficacy 24 weeks of treatment. Few studies have examined whether provides additional therapeutic benefit.To compare (standard), (extended), 52 (maintenance) patch treatment promoting tobacco abstinence.We recruited 525 treatment-seeking smokers a randomized clinical trial conducted from June 22, 2009, through April 15,...
BACKGROUND Assays identifying circulating tumor cells (CTCs) allow noninvasive and sequential monitoring of the status primary or metastatic tumors, potentially yielding clinically useful information. However, to authors' knowledge, effect radiation therapy (RT) on CTCs in patients with non–small cell lung cancer (NSCLC) has not been previously explored. METHODS This report describes results from a pilot study 30 NSCLC who received RT. Peripheral blood samples obtained these were assayed for...
The esophageal lumen is lined by a stratified squamous epithelium comprised of proliferative basal cells that differentiate while migrating toward the luminal surface and eventually desquamate. Rapid epithelial renewal occurs, but specific cell origin supports this high demand remains unknown. Herein, we have described long-lived progenitor population in mouse characterized expression keratin 15 (Krt15). Genetic vivo lineage tracing revealed Krt15 promoter marks able to self-renew,...
Purpose Sorafenib is currently the only Food and Drug Administration-approved first-line therapy for patients with advanced hepatocellular carcinoma. There are few data examining how sorafenib starting dose may influence patient outcomes costs. Patients Methods We retrospectively evaluated 4,903 from 128 Veterans Health Administration hospitals who were prescribed carcinoma between January 2006 April 2015. After 1:1 propensity score matching to account potential treatment bias, hazard ratios...
Despite the efficacy of bupropion for smoking cessation, smokers exhibit variability in treatment outcome. The CYP2B6 gene has been implicated kinetics and nicotine metabolism, is a plausible candidate pharmacogenetic studies response. We investigated whether functional genetic polymorphism predicts outcomes placebo-controlled randomized trial. Four hundred twenty-six European Caucasian ancestry provided blood samples received (300 mg/day 10 weeks) or placebo, plus counseling. Smoking...
This study examined the role of dopaminergic genes in prospective smoking cessation and response to bupropion treatment a placebo-controlled clinical trial. Smokers European ancestry (N=418) provided blood samples for genetic analysis received either or placebo (10 weeks) plus counseling. Assessments included dopamine D2 receptor (DRD2) genotype, transporter (SLC6A3) demographic factors, nicotine dependence. Smoking status was verified at end (EOT) 6-month follow-up. The results evidence...
OBJECTIVES. The objectives of our study were to evaluate whether genetic variation in nicotine metabolic inactivation accounted for the emergence dependence from mid- late adolescence and initial smoking experiences mediated this effect. METHODS. Participants 222 adolescents European ancestry who participated a longitudinal cohort biobehavioral determinants adolescent smoking. Survey data collected annually grade 9 end 12. Self-report measures included dependence, smoking, age first smoked,...