A5008766644- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Smoking Behavior and Cessation
- Nicotinic Acetylcholine Receptors Study
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Face Recognition and Perception
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Memory and Neural Mechanisms
- Deception detection and forensic psychology
- Menopause: Health Impacts and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Behavioral Health and Interventions
- Biochemical Analysis and Sensing Techniques
- Treatment of Major Depression
- Health, Environment, Cognitive Aging
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Music Perception
- Multisensory perception and integration
- Memory Processes and Influences
University of Pennsylvania
2016-2025
Colorado School of Public Health
2024
California University of Pennsylvania
2018-2022
Philadelphia University
2007-2020
Collaborative Research Group
2016
Hospital of the University of Pennsylvania
2004-2013
United States Department of Veterans Affairs
2012
RWTH Aachen University
2010
Jülich Aachen Research Alliance
2010
Drexel University
2010
Examine age group effects and sex differences by applying a comprehensive computerized battery of identical behavioral measures linked to brain systems in youths that were already genotyped. Such information is needed incorporate data as neuropsychological "biomarkers" large-scale genomic studies.
Ethologist Konrad Lorenz proposed that baby schema ('Kindchenschema') is a set of infantile physical features such as the large head, round face and big eyes perceived cute motivates caretaking behavior in other individuals, with evolutionary function enhancing offspring survival. Previous work on this fundamental concept was restricted to schematic representations or correlative approaches. Here, we experimentally tested effects perception cuteness motivation for using photographs infant...
Abstract Deception is a clinically important behavior with poorly understood neurobiological correlates. Published functional MRI (fMRI) data on the brain activity during deception indicates that, multisubject group level, lie distinguished from truth by increased prefrontal and parietal activity. These findings are theoretically important; however, their applied value will be determined accuracy of discrimination between single deceptive truthful responses in individual subjects. This study...
Ethologist Konrad Lorenz defined the baby schema (“Kindchenschema”) as a set of infantile physical features, such round face and big eyes, that is perceived cute motivates caretaking behavior in human, with evolutionary function enhancing offspring survival. The neural basis this fundamental altruistic instinct not well understood. Prior studies reported pattern brain response to pictures children, but did dissociate from children. Using functional magnetic resonance imaging controlled...
Adolescence is characterized by rapid development of executive function. Working memory (WM) a key element function, but it not known what brain changes during adolescence allow improved WM performance. Using fractal n-back fMRI paradigm, we investigated responses to load in 951 human youths aged 8-22 years. Compared with more limited associations age, performance was robustly associated both network activation and deactivation the default mode network. Multivariate patterns predicted task...
<h3>Importance</h3> Interactions of large-scale brain networks may underlie cognitive dysfunctions in psychiatric and addictive disorders. <h3>Objectives</h3> To test the hypothesis that strength coupling among 3 networks—salience, executive control, default mode—will reflect state nicotine withdrawal (vs smoking satiety) will predict abstinence-induced craving deficits to develop a resource allocation index (RAI) reflects combined interactions networks. <h3>Design, Setting,...
Understanding the neurobiological substrates of self-recognition yields important insight into socially and clinically critical cognitive functions such as theory mind. Experimental evidence suggests that right frontal parietal lobes preferentially process self-referent information. Recognition one's own face is an parameter self-recognition, but well-controlled experimental data on brain self-face recognition limited. The goal this study was to characterize activation specific in comparison...
Context: Deficits in emotion processing are prominent schizophrenia, and flat affect is resistant to treatment portends poor outcome.Investigation of the underlying neural circuitry can elucidate affective dysfunction.Objective: To examine brain for facial processing, dissecting response task demands from effects appearance expressions.Design: A identification was presented during high-field (4-T) magnetic resonance imaging.Blood oxygenation level-dependent changes were contrasted compared...
Objective: Environmental drug-related cues have been implicated as a cause of illicit heroin use during methadone maintenance treatment dependence. The authors sought to identify the functional neuroanatomy brain response visual heroin-related stimuli in patients. Method: Event-related magnetic resonance imaging was used compare responses and matched neutral 25 patients treatment. Patients were studied before after administration their regular daily dose. Results: heightened insula,...
Both emotion and visual processing deficits are documented in schizophrenia, preferential magnocellular pathway dysfunction has been reported several studies.This study examined the contribution to emotion-processing of parvocellular function, based on stimulus properties shape contrast response functions.Experiment 1 relationship between sensitivity magnocellular-and parvocellular-biased stimuli recognition using Penn Emotion Recognition (ER-40) Differentiation (EMODIFF) tests.Experiment 2...
Evidence points to the endogenous opioid system, and mu-opioid receptor (MOR) in particular, mediating rewarding effects of drugs abuse, including nicotine. A single nucleotide polymorphism (SNP) human MOR gene (OPRM1 A118G) has been shown alter protein level preclinical models smoking behavior humans. To clarify underlying mechanisms for these associations, we conducted an vivo investigation OPRM1 A118G genotype on binding potential (BP(ND) or availability). Twenty-two smokers prescreened...