A5045818277- Neural dynamics and brain function
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Hearing Loss and Rehabilitation
- Treatment of Major Depression
- Multisensory perception and integration
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Amino Acid Enzymes and Metabolism
- Mental Health and Psychiatry
- Face Recognition and Perception
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Music Therapy and Health
- Bipolar Disorder and Treatment
Nathan Kline Institute for Psychiatric Research
2016-2025
Columbia University
2016-2025
University School
2003-2025
Columbia University Irving Medical Center
2015-2024
New York State Psychiatric Institute
2014-2022
New York Psychoanalytic Society and Institute
2014-2022
Wilmington University
2022
University of Southern California
2020
Cold Spring Harbor Laboratory
2020
University College London
2020
The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls an acceleration discovery and the delineation developmental trajectories risk resilience across lifespan. To attain these objectives, sufficiently powered datasets with broad deep phenotypic characterization, state-of-the-art neuroimaging, genetic samples must be generated made openly available to scientific community. enhanced Nathan Kline Institute-Rockland Sample (NKI-RS) is a response this...
Viewing a speaker's articulatory movements substantially improves listener's ability to understand spoken words, especially under noisy environmental conditions. It has been claimed that this gain is most pronounced when auditory input weakest, an effect related well-known principle of multisensory integration--"inverse effectiveness." In keeping with the predictions principle, present study showed substantial in speech enhancement at even lowest signal-to-noise ratios (SNRs) used (-24 dB),...
Psychiatry lacks the objective clinical tests routinely used in other specializations. Novel computerized methods to characterize complex behaviors such as speech could be identify and predict psychiatric illness individuals.In this proof-of-principle study, our aim was test automated analyses combined with Machine Learning later psychosis onset youths at high-risk (CHR) for psychosis.Thirty-four CHR (11 females) had baseline interviews were assessed quarterly up 2.5 years; five transitioned...
<h3>Background</h3> In patients with schizophrenia, deficient generation of mismatch negativity (MMN)—an event-related potential (ERP) indexing auditory sensory ("echoic") memory—and a selective increase "context dependent" ("BX") errors in the "A-X" version Continuous Performance Test (AX-CPT) indicate an impaired ability to form and use transient memory traces. Animal human studies implicate deficient<i>N</i>-methyl-D-aspartate receptor (NMDAR) functioning such abnormalities. this study,...
<h3>Background</h3> Disturbances of<i>N</i>-methyl-D-aspartate (NMDA) receptor–mediated glutamatergic neurotransmission may play an important role in the pathophysiology of negative symptoms schizophrenia. Glycine, a small nonessential amino acid, functions as obligatory coagonist at NMDA receptors through its action strychnine-insensitive binding site on receptor complex. Glycine-induced augmentation thus offer potentially safe and feasible approach for ameliorating persistent...
We investigated the convergence of somatosensory and auditory inputs in within subregions macaque cortex. Laminar current source density multiunit activity profiles were sampled with linear array multielectrodes during penetrations posterior superior temporal plane three monkeys. At each recording site, responses to binaural clicks, pure tones, band-passed noise, all presented by earphones, compared evoked contralateral median nerve stimulation. Subjects awake but not required discriminate...
Using high-field (3 Tesla) functional magnetic resonance imaging (fMRI), we demonstrate that auditory and somatosensory inputs converge in a subregion of human cortex along the superior temporal gyrus. Further, simultaneous stimulation both sensory modalities resulted activity exceeding predicted by summing responses to unisensory inputs, thereby showing multisensory integration this convergence region. Recently, intracranial recordings macaque monkeys have shown similar...
Patients with schizophrenia frequently present negative symptoms and cognitive impairments for which no effective treatments are known. Agents that act at the glycine site of N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising moderate to severe impairments.The Cognitive Negative Symptoms in Schizophrenia Trial (CONSIST) was a 16-week double-blind, double-dummy, parallel group, randomized clinical trial adjunctive glycine, D-cycloserine, or placebo...
Multisensory interactions are observed in species from single-cell organisms to humans. Important early work was primarily carried out the cat superior colliculus and a set of critical parameters for their occurrence were defined. Primary among these temporal synchrony spatial alignment bisensory inputs. Here, we assessed whether also parameter temporally earliest multisensory that lower-level sensory cortices human. While humans have been shown behaviorally spatially disparate stimuli (e.g....
Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This emits signal termed mismatch negativity (MMN) when any detectable change regular pattern of stimulation occurs. The precise intracranial sources underlying MMN generation, and particular whether these vary as function acoustic feature that changes, is matter some debate. Using functional magnetic resonance imaging, we show anatomically distinct networks cortices are activated...
<h3>Background</h3> Patients with schizophrenia show deficits in early-stage visual processing, potentially reflecting dysfunction of the magnocellular pathway. The system operates normally a nonlinear amplification mode mediated by glutamatergic (<i>N</i>-methyl-D-aspartate) receptors. Investigating therefore permits evaluation underlying etiologic hypotheses. <h3>Objectives</h3> To evaluate schizophrenia, relative to known neurochemical and neuroanatomical substrates, examine relationships...
Language and speech are the primary source of data for psychiatrists to diagnose treat mental disorders. In psychosis, very structure language can be disturbed, including semantic coherence (e.g., derailment tangentiality) syntactic complexity concreteness). Subtle disturbances in evident schizophrenia even prior first psychosis onset, during prodromal stages. Using computer-based natural processing analyses, we previously showed that, among English-speaking clinical ultra) high-risk youths,...