A5025363370- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Neuroblastoma Research and Treatments
- MRI in cancer diagnosis
- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Advanced Biosensing Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Childhood Cancer Survivors' Quality of Life
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer-related cognitive impairment studies
University of California, San Francisco
2013-2025
University of Pennsylvania
2015-2024
California University of Pennsylvania
2018-2024
Hospital of the University of Pennsylvania
2009-2023
Philadelphia University
2012-2023
Children's Hospital of Philadelphia
2002-2023
University of Oxford
2023
Touro University California
2019
Yale Cancer Center
2018
Yale University
2013-2018
Abstract Glioblastoma is the most common aggressive adult brain tumor. Numerous studies have reported results from either private institutional data or publicly available datasets. However, current public datasets are limited in terms of: a) number of subjects, b) lack consistent acquisition protocol, c) quality, d) accompanying clinical, demographic, and molecular information. Toward alleviating these limitations, we contribute “University Pennsylvania Imaging, Genomics, Radiomics”...
Abstract We investigated whether increasing levels of tissue hypoxia, measured by the binding EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] or Eppendorf needle electrodes, were associated with tumor aggressiveness in patients previously untreated glial brain tumors. hypothesized that more extensive and severe hypoxia would be present cells from bearing clinically aggressive Hypoxia was 2-nitroimidazole imaging agent 18 supratentorial neoplasms. In 12 patients,...
Assumptions about the damaging effects of radiotherapy (XRT) are based on studies in which total dose, dose fraction, treatment volume, degree malignancy, chemotherapy, tumor recurrence, and neurologic comorbidity interact with XRT effects. This is a prospective, long-term study adults, fraction were constrained data related to recurrence (e.g., hypertension) excluded.The cognitive radiographic outcomes 26 patients low-grade, supratentorial, brain tumors yearly from baseline (6 weeks after...
Abstract Purpose: To determine the disease control rate and toxicity of treating patients with aggressive cutaneous squamous cell carcinoma (CSCC) neoadjuvant gefitinib. Experimental Design: A prospective phase II clinical trial evaluating gefitinib given prior to standard treatment surgery and/or radiotherapy. Patients stable after one cycle received escalated doses. who responded were during radiation therapy, as well maintenance therapy definitive treatment. We analyzed correlation...
Blood tests to detect circulating tumor cells (CTC) offer great potential monitor disease status, gauge prognosis, and guide treatment decisions for patients with cancer. For brain tumors, such as aggressive glioblastoma multiforme, CTC assays are needed that do not rely on expression of cancer cell surface biomarkers like epithelial adhesion molecules tumors tend lack. Here, we describe a strategy based telomerase activity, which is elevated in nearly all but normal cells. This uses an...
<h3>BACKGROUND AND PURPOSE:</h3> Early assessment of treatment response is critical in patients with glioblastomas. A combination DTI and DSC perfusion imaging parameters was evaluated to distinguish glioblastomas true progression from mixed pseudoprogression. <h3>MATERIALS METHODS:</h3> Forty-one exhibiting enhancing lesions within 6 months after completion chemoradiation therapy were retrospectively studied. All underwent surgery MR histologically classified as having (>75% tumor),...
The remarkable heterogeneity of glioblastoma, across patients and over time, is one the main challenges in precision diagnostics treatment planning. Non-invasive vivo characterization this using imaging could assist understanding disease subtypes, as well risk-stratification planning glioblastoma. current study leveraged advanced analytics radiomic approaches applied to multi-parametric MRI de novo glioblastoma (n = 208 discovery, n 53 replication), discovered three distinct reproducible...
Background and Purpose— The purposes of this study were to determine the incidence neurovascular events as late complications in pediatric patients with brain tumor evaluate radiation a risk factor. Methods— Patients ascertained using database tertiary care center. Included had primary tumor, age birth 21 years, initial treatment January 1, 1993, December 31, 2002, at least 2 visits neuro-oncology. Radiation exposure included: whole brain, plus focal boost, or brain. outcome was stroke...
Following resection of a brain metastasis, stereotactic radiosurgery (SRS) to the cavity is an emerging alternative postoperative whole-brain radiation therapy (WBRT). This approach attempts achieve local control without neurocognitive risks associated with WBRT. The authors aimed report outcomes large patient cohort treated this strategy.A retrospective review identified 91 patients history WBRT who received Gamma Knife (GK) SRS 96 metastasis cavities between 2007 and 2013. Patterns...
: Circulating tumor cells (CTC) are known to be present in the blood of patients with glioblastoma (GBM). Here we report that GBM-derived CTC possess a cancer stem cell (CSC)-like phenotype and contribute local tumorigenesis recurrence by process self-seeding. Genetic probes showed mouse exhibited Sox2/ETn transcriptional activation expressed glioma CSC markers, consistent robust expression stemness-associated genes including SOX2, OCT4, NANOG human GBM patient-derived samples containing...
Background Imaging of glioblastoma patients after maximal safe resection and chemoradiation commonly demonstrates new enhancements that raise concerns about tumor progression. However, in 30% to 50% patients, these primarily represent the effects treatment, or pseudo‐progression (PsP). We hypothesize quantitative machine learning analysis clinically acquired multiparametric magnetic resonance imaging (mpMRI) can identify subvisual characteristics provide robust, noninvasive signatures...
Abstract Multi-omic data, i.e., clinical measures, radiomic, and genetic capture multi-faceted tumor characteristics, contributing to a comprehensive patient risk assessment. Here, we investigate the additive value independent reproducibility of integrated diagnostics in prediction overall survival (OS) isocitrate dehydrogenase (IDH)-wildtype GBM patients, by combining conventional deep learning methods. Conventional radiomics features were extracted from pre-operative multi-parametric MRI...
Abstract Purpose: Complete alopecia is a universal complication of whole brain radiation therapy which contributes to patient anxiety over treatment. Tempol, nitroxide radioprotector, has been shown protect against radiation-induced in an animal model. This phase Ib study was designed evaluate the safety and side effect profile topical Tempol patients with metastases being treated radiotherapy. Experimental Design: Twelve metastatic cancer were enrolled between October 2000 February 2003....
OBJECTIVE: To review the cumulative experience of 10 institutions in treating recurrent malignant gliomas with brachytherapy device, GliaSite Radiation Therapy System. METHODS: The patient population consisted 95 patients grade 3 or 4 gliomas, a median age 51 years, and Karnofsky performance status score 80. All had previously undergone resection received external beam radiotherapy as part their initial treatment. After recurrence, each underwent maximal surgical debulking lesion placement...
Abstract Glioblastoma is a highly heterogeneous disease, with variations observed at both phenotypical and molecular levels. Personalized therapies would be facilitated by non-invasive in vivo approaches for characterizing this heterogeneity. In study, we developed unsupervised joint machine learning between radiomic genomic data, thereby identifying distinct glioblastoma subtypes. A retrospective cohort of 571 IDH-wildtype patients were included the pre-operative multi-parametric MRI scans...
To determine the accuracy of relative cerebral blood volume (rCBV) fraction for distinguishing high-grade recurrent neoplasm from treatment-related necrosis (TRN) in enhancing masses identified on surveillance magnetic resonance (MR) images following treatment primary or secondary brain neoplasm.This institutional review board approved and HIPAA-compliant retrospective study included 30 patients undergoing resection mass appearing after with surgery radiation, without chemotherapy. The was...