A5031221737- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Head and Neck Cancer Studies
- Salivary Gland Disorders and Functions
- Advanced Radiotherapy Techniques
- Oral health in cancer treatment
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Radiation Effects and Dosimetry
- Radiation Effects in Electronics
- Effects of Radiation Exposure
- Gamma-ray bursts and supernovae
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Plant Genetic and Mutation Studies
- Electron Spin Resonance Studies
- Photoreceptor and optogenetics research
- Phonocardiography and Auscultation Techniques
- Enterobacteriaceae and Cronobacter Research
- Ultrasound and Hyperthermia Applications
- Hand Gesture Recognition Systems
- Space Technology and Applications
- Spectroscopy and Chemometric Analyses
- Ultrasound Imaging and Elastography
- Statistical Methods in Clinical Trials
Ion Beam Applications (Belgium)
2012-2025
University of Castilla-La Mancha
2016
Cliniques Universitaires Saint-Luc
2015
Helmholtz-Zentrum Dresden-Rossendorf
2015
UCLouvain
2015
Politecnico di Milano
2015
European Society for Therapeutic Radiology and Oncology
2015
In this work, we present experimental results of a prompt gamma camera for real-time proton beam range verification. The detection system features pixelated Cerium doped lutetium based scintillation crystal, coupled to Silicon PhotoMultiplier arrays, read out by dedicated electronics. uses knife-edge slit collimator produce 1D projection the path in target on detector. We designed detector provide high counting statistics and photo-detection efficiency rays several MeV. design favours could...
Ion beam therapy promises enhanced tumour coverage compared to conventional radiotherapy, but particle range uncertainties significantly blunt the achievable precision. Experimental tools for verification in real-time are not yet available clinical routine. The prompt gamma ray timing method has been recently proposed as an alternative collimated imaging systems. detection times of rays encode essential information about depth-dose profile thanks measurable transit time ions through matter....
Proton ranges in water between 145 MeV to 227 initial energy have been measured at a clinical superconducting synchrocyclotron using the acoustic signal induced by ion dose deposition (ionoacoustic effect). Detection of ultrasound waves was performed very sensitive hydrophone and signals were stored digital oscilloscope triggered secondary prompt gammas. The ionoacoustic range measurements compared existing data from calibrated detector setup on-site agreement better than 1 mm found Bragg...
Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients' quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not reported. area C57BL/6 mice was irradiated a single...
Purpose: To measure the acoustic signal generated by a pulsed proton spill from hospital‐based clinical cyclotron. Methods: An electronic function generator modulated IBA C230 isochronous cyclotron to create beam. The emissions beam were measured in water using hydrophone. measurements repeated with increasing current and distance between detector Results: spills rise times of 18 μ s maximum instantaneous 790 nA. Acoustic energy deposition be on order mPa. origin wave was identified as based...
Proton and ion beam therapies become increasingly relevant in radiation therapy. To fully exploit the potential of this irradiation technique to achieve maximum target volume conformality, verification particle ranges is highly desirable. Many research activities focus on measurement spatial distributions prompt gamma rays emitted during irradiation. A passively collimating knife-edge slit camera a promising option perform such measurements. In former publications, feasibility accurate...
Ultra-high dose rate radiotherapy elicits a biological effect (FLASH), which has been shown to reduce toxicity while maintaining tumor control in preclinical radiobiology experiments. FLASH depends on the rate, with evidence that higher rates drive increased normal tissue sparing. The pattern of delivery also significance for conformal proton delivered via pencil beam scanning (PBS) given its unique spatio-temporal distribution deposition. In PBS, machine-generated log file contains...
Abstract Background Cyclotron‐based proton therapy systems utilize the highest energies to achieve an ultra‐high dose rate (UHDR) for FLASH radiotherapy. The deep‐penetrating range associated with this high energy can be modulated by inserting a uniform plate of proton‐stopping material, known as shifter, in beam path at nozzle bring Bragg peak within target while ensuring transport efficiency UHDR. Aluminum has been recently proposed shifter material mainly due its compactness and...
Purpose: Measurement of the arrival times thermoacoustic waves induced by pulsed proton dose depositions (protoacoustics) may provide a range verification method. The goal this study is to characterize required and protoacoustic (distance) accuracy in homogeneous water medium at hospital‐based clinical cyclotron. Methods: Gaussian‐like pulses with 17 μ s widths instantaneous currents 480 nA (5.6 × 10 7 protons/pulse, 3.4 cGy/pulse Bragg peak) were generated modulating cyclotron source...
Prompt γ-ray imaging with a knife-edge shaped slit camera provides the possibility of verifying proton beam range in tumor therapy. Dedicated experiments regarding characterization system have been performed previously. Now, we aim at implementing prototype into clinical application monitoring patient treatments. Focused on this goal translation operation, systematically addressed remaining challenges and questions. We developed robust energy calibration routine corresponding quality...
To introduce a fast ray-tracing algorithm in pencil proton radiography (PR) with multilayer ionization chamber (MLIC) for vivo range error mapping.Pencil beam PR was obtained by delivering spots uniformly positioned square (45 × 45 mm2 field-of-view) of 9 capable crossing the phantoms (210 MeV). The exit collected MLIC to sample integral depth dose (IDDMLIC). PRs an electron-density and head phantom were acquired moving couch obtain multiple frames. map corresponding errors, two-dimensional...
With increasing availability of proton and particle therapy centers for tumor treatment, the need in vivo range verification methods comes more into focus. Imaging prompt gamma rays emitted during treatment is one possibilities currently under investigation. A knife-edge shaped slit camera was recently proposed this task measurements proved feasibility deviation detection homogeneous inhomogeneous targets. In present paper, we concentrate on laterally materials, which lead to mixing...
Irradiation log-files store useful information about the plan delivery, and together with independent Monte Carlo dose engine calculations can be used to reduce time needed for patient-specific quality assurance (PSQA). Nonetheless, machine carry an uncertainty associated measurement of spot position intensity that influence correct evaluation treatment delivery. This work addresses problem inclusion these uncertainties final verification Dedicated measurements performed in IBA Proteus Plus...
Proton radiography seems to be a promising tool for assessing the quality of stopping power computation in proton therapy. However, range error maps obtained on basis radiographs are very sensitive small misalignment between planning CT and acquisitions. In order able mitigate postprocessing, authors implemented fast method registration pencil data with multilayer ionization chamber (MLIC) an X-ray acquired head phantom.The was performed by optimizing cost function which performs comparison...
In proton therapy planning, the accuracy of Stopping Power Ratios (SPR) calculated in stoichiometric CT calibration is affected by, among others, uncertainties on mean excitation energies (I-values) human tissues and water. Traditionally, contribution these SPR has been conservatively estimated order 1% or more for a reference tissue known composition. This study provides methodology that enables finer estimation this uncertainty, eventually showing traditional estimates uncertainty are too...
Treatments delivered by proton therapy are affected uncertainties on the range of beam within patient. To reduce these margins and deliver safer treatments, different projects currently investigating real-time control imaging prompt gammas emitted along tracks in This study reports development test a gamma camera using slit collimator to obtain 1-dimensional projection path scintillator detector. A first prototype HICAM detector, originally developed for low-energy gamma-ray nuclear medicine...
ICTR-PHE 2016 S89 accuracy derived from the experiment was: DD (5%) -83.4% and 68% pixels passing, DTA (3mm) -99.0% 96,7%, gamma parameter (for (3%), (3mm)) -90% 75,5% respectively for AAA PBC algorithms.The comparison between studied parameters DD, γ both algorithms implicated as an appropriate approach in radiotherapy treatment planning.
Purpose: Prompt gammas are emitted along the proton beam path and have an emission profile correlated with depth dose profile. In this study, accuracy of in-vivo range verification using a 1-D prompt gamma camera is assessed. Methods: The comprised tungsten slit collimator positioned in front linear array LYSO scintillating crystals coupled to silicon photomultipliers. imaged profiles individual pencil spots energy layers were analyzed by determining relative shifts from expected based on...
<p>The beam profile, as acquired with the film for irradiation 16 Gy proton.</p>
<p>Estimation of saliva flow in male C57BL/6 mice following irradiation with a single dose 16 Gy proton irradiation.</p>