A5071059881- Head and Neck Cancer Studies
- Salivary Gland Disorders and Functions
- Oral health in cancer treatment
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
The Gurdon Institute
2025
University of Cambridge
2025
Dana-Farber Cancer Institute
2025
Harvard University
2025
University of Pennsylvania
2023-2024
George Washington University
2023
PurposeStudies during the past 9 years suggest that delivering radiation at dose rates exceeding 40 Gy/s, known as "FLASH" therapy, enhances therapeutic index of therapy (RT) by decreasing normal tissue damage while maintaining tumor response compared with conventional (or standard) RT. This study demonstrates cardioprotective benefits FLASH proton RT (F-PRT) standard (conventional) (S-PRT), evidenced reduced acute and chronic cardiac toxicities.Methods MaterialsMice were imaged using cone...
Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients' quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not reported. area C57BL/6 mice was irradiated a single...
Macrophages comprise a significant portion of the immune cell compartment within tumors and are known contributors to tumor pathology; however, cancer immunotherapies targeting these cells not clinically available. The iron oxide nanoparticle, ferumoxytol (FH), may be utilized as nanophore for drug delivery tumor-associated macrophages. We have demonstrated that vaccine adjuvant, monophosphoryl lipid A (MPLA), can stably captured carbohydrate shell without chemical modification either or...
Abstract Background: Immune checkpoint blockade (ICB), the blocking of immune molecules using therapeutic antibodies, has transformed cancer care for over a decade. But while highly efficacious several malignancies, challenges remain widespread adoption ICB therapy including primary and acquired resistance immune-related adverse events. Targeted protein degradation represents an alternative modality in which can be degraded from cell surfaces targeted manner, thereby preventing their...
Abstract Background: Oral mucositis is among the most prevalent side effects of head and neck cancer (HNC) therapy, impacting over 40% patients treated with chemotherapy 90% those chemoradiation. This widespread inflammation oral mucosa represents a major obstacle to treatment quality life HNC often precursor subsequent complications like dysphagia infections. Although progress has been made in deciphering mechanisms mucositis, models study this chemoradiotoxicity have largely limited...
<p>The beam profile, as acquired with the film for irradiation 16 Gy proton.</p>
<p>Estimation of saliva flow in male C57BL/6 mice following irradiation with a single dose 16 Gy proton irradiation.</p>
<p>Histopathological analysis of submandibular gland tissues post-28 days irradiation with S-PRT/F-PRT.</p>
<p>The percent difference in body weight of mice after irradiation with a hypofractionated regime 8 Gy x 3.</p>
<p>Detection of oral mucositis as observed after staining with 1% Toluidine Blue.</p>
<p>Immunofluoresecnce of TUNEL and AQP5 after 10 days post irradiation PRT.</p>
<p>F-PRT reduces radiation-induced damage to the oral cavity compared S-PRT.</p>
<p>The percent difference in body weight of mice after irradiation with a hypofractionated regime 8 Gy x 3.</p>
<p>F-PRT reduces radiation-induced damage to the oral cavity compared S-PRT.</p>
<p>The beam profile, as acquired with the film for irradiation 16 Gy proton.</p>
<div>Abstract<p>Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients’ quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not...
<p>Estimation of saliva flow in male C57BL/6 mice following irradiation with a single dose 16 Gy proton irradiation.</p>
<p>Histopathological analysis of submandibular gland tissues post-28 days irradiation with S-PRT/F-PRT.</p>
<p>Detection of oral mucositis as observed after staining with 1% Toluidine Blue.</p>
<p>Immunofluoresecnce of TUNEL and AQP5 after 10 days post irradiation PRT.</p>
<div>Abstract<p>Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients’ quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not...