Nicolas Denef
A5095111047- Head and Neck Cancer Studies
- Salivary Gland Disorders and Functions
- Oral health in cancer treatment
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
Ion Beam Applications (Belgium)
2024
Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients' quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not reported. area C57BL/6 mice was irradiated a single...
<p>The beam profile, as acquired with the film for irradiation 16 Gy proton.</p>
<p>Estimation of saliva flow in male C57BL/6 mice following irradiation with a single dose 16 Gy proton irradiation.</p>
<p>Histopathological analysis of submandibular gland tissues post-28 days irradiation with S-PRT/F-PRT.</p>
<p>The percent difference in body weight of mice after irradiation with a hypofractionated regime 8 Gy x 3.</p>
<p>Detection of oral mucositis as observed after staining with 1% Toluidine Blue.</p>
<p>Immunofluoresecnce of TUNEL and AQP5 after 10 days post irradiation PRT.</p>
<p>F-PRT reduces radiation-induced damage to the oral cavity compared S-PRT.</p>
<p>The percent difference in body weight of mice after irradiation with a hypofractionated regime 8 Gy x 3.</p>
<p>F-PRT reduces radiation-induced damage to the oral cavity compared S-PRT.</p>
<p>The beam profile, as acquired with the film for irradiation 16 Gy proton.</p>
<div>Abstract<p>Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients’ quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not...
<p>Estimation of saliva flow in male C57BL/6 mice following irradiation with a single dose 16 Gy proton irradiation.</p>
<p>Histopathological analysis of submandibular gland tissues post-28 days irradiation with S-PRT/F-PRT.</p>
<p>Detection of oral mucositis as observed after staining with 1% Toluidine Blue.</p>
<p>Immunofluoresecnce of TUNEL and AQP5 after 10 days post irradiation PRT.</p>
<div>Abstract<p>Head and neck cancer radiotherapy often damages salivary glands oral mucosa, severely negatively impacting patients’ quality of life. The ability FLASH proton (F-PRT) to decrease normal tissue toxicity while maintaining tumor control compared with standard (S-PRT) has been previously demonstrated for several tissues. However, its potential in ameliorating radiation-induced gland dysfunction mucositis controlling orthotopic head growth not...