A5101531143- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Ovarian cancer diagnosis and treatment
- Iron Metabolism and Disorders
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Oral health in cancer treatment
Xian Central Hospital
2025
Xi'an Jiaotong University
2025
Yan'an University
2025
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
Southern Medical University
2016-2024
University of Colorado Denver
2021-2024
University of Colorado Cancer Center
2021-2024
Zhuhai People's Hospital
2024
Zhongnan Hospital of Wuhan University
2023
Poor nutritional status is associated with progression and advanced disease in patients cancer. The prognostic index (PNI) may represent a simple method of assessing host immunonutritional status. This study was designed to investigate the value PNI for distant metastasis-free survival (DMFS) nasopharyngeal carcinoma (NPC).A training cohort 1,168 non-metastatic NPC from two institutions retrospectively analyzed. optimal cutoff DMFS identified using online tool "Cutoff Finder". analyzed...
Human serum microRNAs (miRNAs) have been shown to serve as disease fingerprints for predicting survival of cancer patients. However, the roles specific miRNAs involved in gastric (GC) are largely unknown. In this study, miRNA profiling was performed on sera obtained from six patients good- and poor-survival groups. Expression miR-423-3p validated by quantitative RT-PCR another 67 GC samples paired normal cancerous tissues. Luciferase reporter assays were used identify target gene...
Approximately 70% of treatment failures in nasopharyngeal carcinoma (NPC) patients are attributed to distant metastasis, yet the underlying mechanisms remain unclear. RNA 5-methylcytosine (m5C) is an emerging regulatory modification that controls gene expression and plays a critical role tumor progression. However, there little information on potential roles m5C NPC metastasis. In this study, we found reader Aly/REF export factor (ALYREF) significantly upregulated NPC, whereby its high...
We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and develop a novel cytokine-based classifier (CBPC) for prediction. A total 176 were divided into two cohorts based on date first-line chemotherapy. The first 99 cases assigned training cohort, remaining 77 validation cohort. Thirty-nine simultaneously analyzed patient serum samples using multiplex bead-based Luminex technology. used support vector...
The prevalence of lymphedema is rising, necessitating accurate diagnostic and treatment information for affected patients. Short video-sharing platforms facilitate access to such but require validation regarding the reliability quality content presented. This study aimed assess lymphedema-related on Chinese short platforms. We collected 111 video samples addressing diagnosis from four platforms: TikTok, Bilibili, WeChat, Microblog. Two independent surgeons evaluated each comprehensiveness,...
The modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). systemic inflammation score (SIS) has been shown to be more informative than mGPS in CRC. albumin-NLR, composed of albumin NLR, can also a candidate valuable score. However, about utility mGPS, SIS, albumin-NLR CRC patients who have received radical resections remains unclear.This study enrolled 877 patients, underwent surgical...
8008 Background: Enhancing clinical outcomes in resectable non-small cell lung cancer (NSCLC) has been associated with neoadjuvant or perioperative administration of nivolumab. However, the efficacy and safety consolidation nivolumab versus observation following chemotherapy plus nivolumab, hypofractionated radiotherapy concurrent (hypo-CCRT) patients unresectable stage III NSCLC remain underexplored. Methods: Conducted as a randomized, multi-center, phase 2 trial IIIA-C NSCLC, this study...
BACKGROUND Colorectal cancer (CRC) is one of the main causes cancer-related deaths in China and around world. Advanced CRC (ACRC) patients suffer from a low cure rate though treated with targeted therapies. The response about 50% to chemotherapy cetuximab, monoclonal antibody targeting epidermal growth factor receptor (EGFR) used for ACRC wild-type KRAS. It important identify more predictors cetuximab efficacy further improve precise treatment. Autophagy, showing key role progression,...
Background: Published papers reported contradictory results about the correlation between bevacizumab effectiveness and primary tumor location of metastatic colorectal cancer (mCRC). Methods: 740 mCRC patients treated with chemotherapy (CT group) 244 plus as first-line setting + B were included. Propensity score analyses used for patients' stratification matching. Kaplan-Meier curves log-rank tests to detect different overall survival (OS). Results: Patients in CT group had similar OS...
Markers to predict the efficacy of bevacizumab treatment have been not fully validated in most cancers, including metastatic colorectal cancer (mCRC). The aim this study was investigate potential role lactate dehydrogenase (LDH) predicting survival benefit from first-line treatment, Chinese patients with mCRC.All were diagnosed mCRC at Sun Yat-sen University Cancer Center 2003 2013. group and control classified by receiving or not. serum LDH value all had detected before treatment. primary...
Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status.However, the prognostic value PD-L1 expression for patients MMR deficiency has not been fully investigated.In this study, we examined association markers, PD-1/PD-L1 pathway expression, microsatellite instability (MSI) clinicopathological characteristics CRC...
We aimed to investigate the role of apolipoprotein A-I (ApoA-I) as a predictor prognosis and treatment efficacy bevacizumab in patients with metastatic colorectal cancer (mCRC) treated first-line chemotherapy or without bevacizumab.We conducted retrospective study on consecutive who were diagnosed mCRC at Sun Yat-sen University Cancer Center. According their pretreatment ApoA-I level, divided into low- high-ApoA-I groups. Propensity score-matched method was performed balance baseline...
We assessed the value of palliative local treatment incurable metastatic lesions in colorectal cancer patients. Consecutive patients with treated between 2003 and 2014 were retrospectively reviewed. Propensity score matching was used to create comparable chemotherapy alone groups (n = 272 each group). The primary endpoint overall survival, which calculated using Kaplan-Meier survival analyses. Factors possibly influencing evaluated by univariate subsequently multivariate Palliative prolonged...
To investigate the prognostic relevance of preoperative peripheral neutrophil- to-lymphocyte ratio (NLR) in gastrointestinal stromal tumor (GIST) patients.We enrolled 129 consecutive GIST patients who underwent initial curative surgical resection with or without adjuvant/palliative imatinib treatment our study. Blood NLR was calculated as neutrophil count (number neutrophils ×10(9)/L) divided by lymphocyte lymphocytes ×10(9)/L). Survival curves were constructed using Kaplan-Meier method....
The skeletal system is the most common site of distant metastasis in nasopharyngeal carcinoma (NPC); various prognostic factors have been reported for metastasis, though studies focused on a single factor. We aimed to establish nomograms effectively predict at initial diagnosis (SMAD) and metastasis-free survival (SMFS) NPC.A total 2685 patients with NPC who received bone scintigraphy (BS) and/or 18F-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) 2496 without...
Abstract Background Vascular endothelial growth factor (VEGF)-targeted therapy is effective in patients with ovarian cancer. Whether adipose tissue (AT) could predict the efficacy of VEGF receptor (VEGFR) inhibitors cancer unknown. We aimed to evaluate ability distinct AT depots apatinib, a VEGFR inhibitor, recurrent cancers included AEROC trial. Methods The was single-arm phase 2 trial apatinib and oral etoposide platinum-resistant or platinum-refractory Apatinib administered continuously,...
Recent studies have indicated that the C-reactive protein/albumin (CRP/ALB) ratio (CAR) may represent a simple inflammation-based index for assessing host inflammatory response. In this study, prognostic value of CAR distant metastasis-free survival (DMFS) in nasopharyngeal carcinoma (NPC) was assessed.A total 1,168 non-metastatic NPC patients from Sun Yat-sen University Cancer Center were retrospectively included. The optimal cutoff defined by Cutoff Finder online tool. Propensity...
Magnetic resonance (MR)-guided microwave ablation is a well-developed technique for the treatment of tumors, especially hepatic carcinomas. However, there are no detailed reports on changes in MR images and histology observed after ablation. This study aimed to dynamically map pathological occurring images. We performed MR-guided 10 Wuzhishan pigs obtained an scan immediately (0 weeks) at 1, 2, 3, 4 weeks compared assessed tissue specimens during follow-up. found significant difference size...
Anti-PD-1)/programmed cell death-ligand 1 (PD-L1) antibody plus platinum-based chemotherapy (PBC) has replaced PBC as first-line treatment for patients with non-squamous (sq) non-small lung cancer (NSCLC) lacking targetable driver mutations. However, few studies have directly compared immune checkpoint inhibitor (ICI) bevacizumab (beva +chemo) in this setting. Herein, we conducted an indirect comparison anti-PD-1/PD-L1 (ICI versus beva +chemo non-sq NSCLC using the frequentist methods. The...
Abstract Background We aim to investigate the prognostic value of weight loss during radiotherapy (RT) among patients with nasopharyngeal carcinoma (NPC). Methods A total 1149 NPC who received radical RT were retrospectively analyzed. Patients’ measured at initiation (W Pre-RT ) and every week RT1,2,3,4,5,6,7 ). Percentage (PWL) 1st, 2nd, 3rd, 4th, 5th, 6th, 7th (RT-PWL 1,2,3,4,5,6,7 calculated using following equation: –W )/W × 100%. The optimal threshold RT-PWL 7 was determined by...