A5005418531- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Renal and related cancers
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Inflammatory mediators and NSAID effects
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
State Key Laboratory of Oncology in South China
2011-2022
Xinjiang Production and Construction Corps
2021
Shanghai University
2020
Nanjing University of Finance and Economics
2012
Key Laboratory of Guangdong Province
2011
Beijing Institute of Technology
2007
PD-L1 is overexpressed in tumor cells and contributes to cancer immunoevasion. However, the role of cell-intrinsic cancers remains unknown. Here we show that regulates lung growth progression by targeting WIP β-catenin signaling. Overexpression promotes cell growth, migration invasion cells, whereas knockdown has opposite effects. We have also identified as a new downstream target cancer. positively modulates expression WIP. Knockdown inhibits viability colony formation, overexpression can...
Berberine (BBR), an isoquinoline derivative alkaloid isolated from Chinese herbs, has a long history of uses for the treatment multiple diseases, including cancers. However, precise mechanisms actions BBR in human lung cancer cells remain unclear. In this study, we investigated molecular by which inhibits cell growth non-small-cell (NSCLC) cells. Treatment with promoted morphology change, inhibited migration, proliferation and colony formation, induced apoptosis. Further mechanism study...
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic distributed in medical herbs, exerts antitumor effects and is emerging as promising compound for cancer prevention therapy, but its excise mechanisms of action colon cells remains largely unknown. Here, we identified the molecular by which UA inhibited cell proliferation induced apoptosis human SW480 LoVo cells. Treatment with led to significant inhibitions viability clone formation changes morphology spreading. also suppressed...
Melatonin is a hormone identified in plants and pineal glands of mammals possesses diverse physiological functions. Fisetin bio-flavonoid widely found exerts antitumor activity several types human cancers. However, the combinational effect melatonin fisetin on activity, especially melanoma treatment, remains unclear. Here, we tested hypothesis that could enhance cells underlying molecular mechanisms. The treatment with significantly enhanced inhibitions cell viability, migration clone...
Background: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare subtype of non-small cell lung cancer (NSCLC), and no effective treatments have been defined for advanced disease. Programmed death-ligand 1 (PD-L1) expressed in group cancers that may be suitable targets specific immunotherapy. Methods: This study investigated the expression clinical value PD-L1 LELC. Seventy-nine patients with LELC were investigated. Paraffin-embedded tumor sections stained antibody....
Cyclin F, capable of forming Skp1-Cul1-F-box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression significance cancer remain obscure. In this study, we showed that was noticeably decreased 16 pairs tissue samples hepatocellular carcinoma (HCC) compared paracarcinoma tissues, at both mRNA levels. Immunohistochemical staining data...
N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential suppressor lung cancer explored its molecular mechanism involved progression.Human cell lines mouse xenograft model was used to study the effect of on growth. The expression NMI, COX-2 relevant signaling proteins were examined by Western blot. Tissue microarray immunohistochemical analysis performed assess correlation between patients.NMI highly...
NR3C2 has previously been described as a tumor suppressor gene in several cancers; however the prognostic significance and biological function of patients with non‐metastatic clear cell renal carcinoma (ccRCC) remain largely unclear. The value expression was evaluated using data from Cancer Genome Atlas (TCGA) 181 ccRCC undergoing nephrectomy our center. Predictive nomograms were generated identified independent prognosticators to assess patient overall survival (OS) progression free (PFS)...
Abstract Background Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It urgent elucidate molecular mechanisms underlying radiotherapy resistance. Methods RNA-seq analysis was applied five paired progressive disease (PD) and complete response (CR) NPC tissues. Loss-and gain-of-function assays were used for oncogenic function FLI1 both vitro vivo. analysis, ChIP dual luciferase reporter performed explore...
Although lipid disequilibrium has been documented for several types of cancer including colorectal (CRC), it remains unknown whether parameters are associated with the outcome metastatic CRC (mCRC) patients. Here, we retrospectively examined profiles 453 mCRC patients and investigated any correlated Pretreatment serum lipids, triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), were collected in initially The LDL-C to HDL-C ratio (LHR) was calculated...
Nuclear receptor coactivator 3 (NCOA3) is a transcriptional that has elevated expression in multiple tumor types, including colorectal cancer (CRC). However, the molecular mechanisms regulate tumorigenic functions of NCOA3 CRC remain largely unknown. In this study, we aimed to discover and identify novel regulatory proteins explore their action. Immunoprecipitation (IP) coupled with mass spectrometry (IP-MS) analysis was used detect, identify, verify interacted cells. The biological...
// Yun Tian 1, * , Lijun Qin 3, Huijuan Qiu Dingbo Shi 1 Rui Sun Wenbing Li Tianze Liu Jingshu Wang Tingting Xu 4 Wei Guo Tiebang Kang Wenlin Huang 5 Guowen 2, Wuguo Deng 5, Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, China 2 Department Bone and Soft Tissue Tumors, Tianjin Medical Institute Hospital, National Clinical Research for Cancer, Prevention Therapy, Tianjin, 3 Pediatrics, Memorial University,...
Brucea javanica oil emulsion (BJOE), the petroleum ether extract of B. emulsified by phospholipid, is widely used in China as an anticancer agent. The extracts from induce cancer cell death various mechanisms; however, it not known whether these mechanisms involve autophagy, which important process development and treatment. Thus, current study aimed to investigate BJOE modulates autophagy HCT116 human colon cells modulation mechanism BJOE. Immunoblotting was employed analyze protein...
Activation of the telomere maintenance mechanism is a key hallmark cancer. Human telomerase reverse transcriptase (hTERT) catalytic subunit telomerase, which highly expressed in more than 80% tumors, including hepatocellular carcinoma (HCC). However, exact mechanisms by hTERT up-regulated HCCs and promotes tumor growth progression not fully understood. The aim this study was to discover novel molecular targets that modulate signaling HCC growth. In study, we pulled down identified RBFOX3...
Background: Published papers reported contradictory results about the correlation between bevacizumab effectiveness and primary tumor location of metastatic colorectal cancer (mCRC). Methods: 740 mCRC patients treated with chemotherapy (CT group) 244 plus as first-line setting + B were included. Propensity score analyses used for patients' stratification matching. Kaplan-Meier curves log-rank tests to detect different overall survival (OS). Results: Patients in CT group had similar OS...
Markers to predict the efficacy of bevacizumab treatment have been not fully validated in most cancers, including metastatic colorectal cancer (mCRC). The aim this study was investigate potential role lactate dehydrogenase (LDH) predicting survival benefit from first-line treatment, Chinese patients with mCRC.All were diagnosed mCRC at Sun Yat-sen University Cancer Center 2003 2013. group and control classified by receiving or not. serum LDH value all had detected before treatment. primary...
Purpose: Mismatch repair-deficient (dMMR) colorectal cancer (CRC) is associated with increased local immune response as compared mismatch repair-proficient (pMMR) CRC. We evaluated the relationship between MMR status and systemic inflammatory factors, including neutrophil lymphocyte ratio (NLR) C-reactive protein (CRP). also assessed prognostic value of these parameters. Methods materials: analysed (obtained by histochemical analysis), counts, NLR, CRP level. The impact factors on survival...
Abnormal expression or mutation of RNA splicing proteins are widely observed in human cancers. Here, we identified poly(U) binding factor 60 (PUF60) as one the most differentially expressed genes out 97 between normal and bladder cancer tissues by bioinformatics analysis TCGA data. The PUF60 was significantly higher tumor tissues, while high associated with malignant phenotypes shorter survival time. Moreover, aurora kinase A (AURKA) a new downstream target cells. knockdown inhibited cell...
We aimed to investigate the role of apolipoprotein A-I (ApoA-I) as a predictor prognosis and treatment efficacy bevacizumab in patients with metastatic colorectal cancer (mCRC) treated first-line chemotherapy or without bevacizumab.We conducted retrospective study on consecutive who were diagnosed mCRC at Sun Yat-sen University Cancer Center. According their pretreatment ApoA-I level, divided into low- high-ApoA-I groups. Propensity score-matched method was performed balance baseline...