A5100339016- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Berberine and alkaloids research
- Inflammatory mediators and NSAID effects
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Fungal Biology and Applications
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Musculoskeletal pain and rehabilitation
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Drug-Induced Adverse Reactions
- Pharmacogenetics and Drug Metabolism
- Acute Myeloid Leukemia Research
- Medical and Biological Ozone Research
- Synthesis of β-Lactam Compounds
- Biosimilars and Bioanalytical Methods
- Complement system in diseases
Cangzhou Central Hospital
2021-2023
University of Waterloo
2021-2023
Shenyang Pharmaceutical University
2023
State Key Laboratory of Oncology in South China
2013-2022
Jilin University
2022
Sun Yat-sen University
2013-2022
Soochow University
2017-2021
Zhangjiagang First People's Hospital
2017-2021
Beihua University
2021
Soochow University
2020
Cyclin F, capable of forming Skp1-Cul1-F-box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression significance cancer remain obscure. In this study, we showed that was noticeably decreased 16 pairs tissue samples hepatocellular carcinoma (HCC) compared paracarcinoma tissues, at both mRNA levels. Immunohistochemical staining data...
Breast cancer is the second most common cause of cancer‑associated mortality among women worldwide, and triple negative breast (TNBC) aggressive subtype cancer. Berbamine (BBM) a traditional Chinese medicine used for treatment leukopenia without any obvious side effects. Recent reports found that BBM has anti‑cancer The present study aimed to investigate effects on TNBC cell lines underlying molecular mechanism. MDA‑MB‑231 cells MCF‑7 cells, two lines, were treated with various...
Pulp injury is one of the most common clinical diseases, and severe cases are usually associated with functional loss tooth, while current treatment modality only a cavity filling procedure without regeneration dentin-pulp complex, thus leading to devitalized brittle tooth. In this study, carbon dots (CDots) excellent biocompatibility prepared from ascorbic acid polyethyleneimine
// Peipei Yang 1, * , Weicai Chen Xuhui Li 2 Grant Eilers 3 Quan He 1 Lili Liu Yeqing Wu Yuehong Wei Yu Jonathan A. Fletcher Wen-Bin Ou 2, Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College Life Sciences, Sci-Tech University, Hangzhou, China Applied Enzymology, Yangtze Delta Region Institute Tsinghua Jiaxing, Zhejiang, Department Pathology, Brigham Women's Hospital Harvard Medical School, Boston, MA, USA These authors contributed equally to this work...
Berbamine (BBM) is a natural product isolated from Berberis amurensis Rupr. We investigated the influence of BBM on cell viability, proliferation, and migration lung cancer cells explored possible mechanisms. The viability proliferation were evaluated by MTT assay, EdU colony formation assay. Migration invasion abilities determined through wound scratch assay Transwell Cell death was staining ELISA. expressions proteins using western blot A xenograft mouse model derived non-small-cell used...
Hepatocellular carcinoma (HCC) is a primary malignancy in the liver, which global health problem. The present study aimed to observe apoptotic effects of berbamine on SMMC-7721 cell lines and investigate induction intrinsic pathway. human HCC cells were cultured morphology observed using phase contrast microscope. apoptosis was examined by employing flow cytometry assay. nuclei stained with DAPI utilizing laser fluorescence Cytochrome c (Cyto c) levels evaluated immunofluorescence staining....
The formation of a hypertrophic scar (HS) may lead to failure glaucoma surgery. Long non‑coding RNAs (lncRNAs) are involved in the HSs. Moreover, family with sequence similarity 225 member B (FAM225B) is upregulated HS. However, role lncRNA FAM225B HS remains unknown. Thus, present study aimed investigate function Scar fibroblasts were isolated from patients who had undergone Western blotting was used detect expressions Bax, Bcl‑2, cleaved caspase 3, p62, ATG7 and Beclin 1, reverse...
Mice deficient in the DNA mismatch repair (MMR) gene, PMS2, develop spontaneous thymic lymphomas and sarcomas. We have previously shown that PMS2(-/-) mice were hypersensitive to a single i.p. injection of 50 mg/kg N-methyl-N-nitrosourea (MNU) for lymphoma induction. postulated MNU sensitivity was due formation O(6)-methylguanine (O(6)-mG), which, if unrepaired by O(6)-alkylguanine alkyltransferase (AGT), leads apoptosis MMR competent cells O(6)-mG:T mismatches cells. Tumor induction is less...
Background. Chronic pain impacts people's activity participation, productivity, mental health, and sense of wellbeing. Purpose. This study aimed to (1) evaluate the feasibility Mindfulness-Based Pain Management (MBCPMTM) program on reducing perception enhancing quality life, (2) understand veterans' experience with program. Method. The pretest-posttest single-group, mixed-methods design was used. Thirty-one veterans were offered 12-week intervention. Catastrophizing Scale (PCS)...