A5060613630- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Multiple and Secondary Primary Cancers
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ion channel regulation and function
- Ion Channels and Receptors
- Brain Tumor Detection and Classification
Sun Yat-sen University Cancer Center
2017-2025
State Key Laboratory of Oncology in South China
2017-2025
Sun Yat-sen University
2017-2025
The First People's Hospital of Tianmen
2025
Colorectal Surgical Associates
2017-2022
University of Colorado Cancer Center
2021
University of Colorado Denver
2021
Inflammation is a common medical complication in colorectal cancer (CRC) patients, which plays significant roles tumor progression and immunosuppression. However, the influence of inflammatory conditions on response to immune checkpoint inhibitors (ICI) incompletely understood. Here we show that patient with high microsatellite instability (MSI-H) CRC local condition, primary progresses but its liver metastasis regresses upon Pembrolizumab treatment. In silico investigation prompted by this...
Background: Our study aimed to evaluate the efficacy and feasibility of neoadjuvant anti–PD-1 treatment for localized mismatch repair–deficient (dMMR) colorectal cancer (CRC). Patients Methods: The cohort included patients with dMMR CRC who received PD-1 inhibitors as therapy from 3 medical centers in Southern China. Main eligibility criteria age between 18 75 years, ECOG performance status 0 or 1, receipt ≥2 doses inhibitors. Results: A total 73 were included. Most tumors locally advanced,...
Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the response to programmed cell death protein (PD-1) blockade in colorectal cancers (CRCs) deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified.
Colorectal cancer with mismatch repair deficiency is usually less aggressive and associated a lower risk of distant metastasis. Immune checkpoint inhibition, rather than traditional chemoradiotherapy, has shown great advantages in treating such patients.This study aimed to verify the hypothesis that locally very advanced (T4b) colorectal without metastases might present higher probability be more sensitive neoadjuvant immune inhibition.This was designed as single-center retrospective...
β2-microglobulin (B2M) and Janus kinases 1 2 (JAK1/2) mutations have been suggested as genetic mechanisms of immune evasion for anti-programmed cell death protein (PD-1) therapy. Whether B2M JAK1/2 lose-of-function mutation can cause primary resistance to anti-PD-1 therapy in colorectal carcinoma (CRC) patients remains controversial. Here, we sought compare the efficacy DNA mismatch repair deficient/microsatellite instability-high CRC with or without mutations. Thirty-Five who received were...
Neoadjuvant anti-PD-1 therapy has shown encouraging efficacy in patients with deficient DNA mismatch repair (dMMR)/microsatellite instability-high (MSI-H) locally advanced rectal cancer (LARC), which suggests its potential as a curative-intent and promising treatment option for organ preservation. We aimed to investigate the long-term outcomes of dMMR/MSI-H LARC who experienced clinical complete response (cCR) after therapy.
N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential suppressor lung cancer explored its molecular mechanism involved progression.Human cell lines mouse xenograft model was used to study the effect of on growth. The expression NMI, COX-2 relevant signaling proteins were examined by Western blot. Tissue microarray immunohistochemical analysis performed assess correlation between patients.NMI highly...
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted growth of human melanoma cells. knockdown significantly inhibited cell viability migration induced apoptosis, whereas overexpression effectively proliferation in various lines. Further study showed that regulated by targeting hTERT-dependent signal pathway. Knockdown markedly...
To develop a prognostic nomogram based on pretreatment 18F-FDG PET-CT radiomics parameters, peripheral blood indicators and clinical characteristics for risk stratification in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC) receiving immunochemotherapy. The eligible were randomly divided into training (n=183) validation (n=79) cohorts. Least absolute shrinkage selection operator regression was used variable selection. Multivariate Cox analysis performed to identify...
Activation of the telomere maintenance mechanism is a key hallmark cancer. Human telomerase reverse transcriptase (hTERT) catalytic subunit telomerase, which highly expressed in more than 80% tumors, including hepatocellular carcinoma (HCC). However, exact mechanisms by hTERT up-regulated HCCs and promotes tumor growth progression not fully understood. The aim this study was to discover novel molecular targets that modulate signaling HCC growth. In study, we pulled down identified RBFOX3...
Colorectal cancer (CRC) is one of the most common malignancies, and early detection plays a crucial role in enhancing curative outcomes. While colonoscopy considered gold standard for CRC diagnosis, noninvasive screening methods DNA methylation biomarkers can improve precancerous lesions.Bioinformatics machine learning were used to evaluate CRC-related genes within TCGA database. By identifying overlapped genes, potential selected further validation. Methylation-specific PCR (MSP) was...
: Background: A comprehensive investigation into immune cell infiltration provides more accurate and reliable prognostic information for patients with colorectal liver oligometastases (CLO) after metastasectomy.Simultaneous detection of the constituents CD3+, CD8+, Foxp3+ T, α-SMA+ cells in oligometastasis 133 was conducted using a four-colour immunohistochemical multiplex technique. Immune were quantified, tumour-infiltrating lymphocyte (TIL) ratios subsequently calculated. Correlation...
The systemic status and local immune status, as determined by the neutrophil-lymphocyte ratio (NLR) or lymphocyte (LYMR) tumor-infiltrating (TIL) count, respectively, have been suggested predictors of tumor response to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, although utility these measures remains controversial. We aimed investigate values LYMR, NLR TIL count their combinations (TIL-LYMR/TIL-NLR) predicting pathologic complete (pCR) after nCRT. Pretreatment biopsy samples data...
Abstract Background It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear. Methods CRC cases after resection were enrolled in Sun Yat-Sen University Cancer Center with intact clinical data. Serum detected by ELISA assay. Immunofluorescent staining examination for CD3 and CD8 slices also conducted. Results Among 65 patients included, recurrence-free...
The aim of this study was to assess the prognostic value CD8+ tumor infiltrating lymphocytes (TIL) combined with programmed cell death-ligand 1 (PD-L1) expression for patients solitary colorectal cancer liver metastasis (SCLM) undergoing R0 resection.Patients curative hepatectomy SCLM were reviewed. Immunohistochemical multiplex technique used quantifying TIL, and immunohistochemical staining assessing PD-L1 expression. immune microenvironment (TIME) classified as strong high TIL low PD-L1,...
Purpose Universal germline testing in patients with colorectal cancer (CRC) a multigene panel can detect various hereditary syndromes. This study was performed to understand how choose and whether the result would affect clinical management. Methods We prospectively enrolled 486 eligible CRC, including all CRC diagnosed under age 70 years over risk features between November 2017 January 2018. All participants received for Results The prevalence of pathogenic variants (PVs) susceptibility...
We launched a screening program for colorectal cancer (CRC) in Yuexiu District, Guangzhou, China, 2014. Here we aimed to report the early results of and evaluate benefits questionnaire.Residents aged between 50 74 were eligible screening. A questionnaire two consecutive fecal immunological tests (FITs) used as primary methods. Subjects who positive any referred further examination with colonoscopy. Neoplasms removed either colonoscopically or by colectomy. Atypical adenoma CRC defined...
Gamma glutamyl-transpeptidase (GGT) has been shown as a prognostic marker in many cancers. The aim of this study was to explore whether serum GGT could predict tumor recurrence patients with liver-confined colorectal cancer liver metastases (CRCLM) undergoing R0 resection.We reviewed who had underwent surgery for CRCLM. Patients liver-only that resection were included. Pre-operative classified into either high or low using cut-off value 33 U/L female and 51 male. Relapse-free survival (RFS)...