Cancer-associated fibroblasts (CAFs) contributes to overall tumor progression. In the current survey, we explored ability of microRNA-20a (miR-20a) within these CAF-derived exosomes influence non-small-cell lung cancer (NSCLC)

Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy often limited by primary drug resistance and/or acquired resistance. The aim of this study was to investigate function miRNA-146a (miR-146a) in DDP-resistant non-small cell cancer (NSCLC), as well underlying mechanisms. effect overexpression miR-146a knockdown cyclin J (CCNJ) A549/DDP and SPC-A1/DDP cells were investigated follows. cellular sensitivity DDP, apoptosis, cycle mobility...

The ubiquitin-conjugating enzyme E2C (UBE2C) has been known as a crucial factor upregulated in various tumors. functions of UBE2C is mainly involved the pathway protein ubiquitination. This study investigates expression gastric cancers and its correlation with overall survival rate.Real-time PCR (RT-PCR) Western blotting were performed to determine cancer samples adjacent normal tissues. Immunohistochemical staining was used assess 216 paraffin-embedded tissues.The mRNA relevant levels...

Treatments for non-small cell lung cancer (NSCLC) have improved tremendously, but therapeutic resistance is a common and major clinical challenge in treatment. Methyltransferase-like 3 (METTL3) ribonucleic acid (RNA) methyltransferase that has crucial functions the development progression of cancers, including drug resistance, by regulating N6-methyladenosine (m6A) modification. However, role METTL3 NSCLC poorly understood.The expression levels AKT serine/threonine kinase 1 (AKT1) tissues...

The modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). systemic inflammation score (SIS) has been shown to be more informative than mGPS in CRC. albumin-NLR, composed of albumin NLR, can also a candidate valuable score. However, about utility mGPS, SIS, albumin-NLR CRC patients who have received radical resections remains unclear.This study enrolled 877 patients, underwent surgical...

The present study aimed to determine that whether L-carnitine infusion could ameliorate fasting-induced adverse effects and improve outcomes.In this 7-day, randomized, single-blind, placebo-controlled, pilot study, 15 metabolic syndrome (MetS) patients (11/4 F/M; age 46.9 ± 9.14 years; body mass index [BMI] 28.2 1.8 kg/m2) were in the group (LC) (10/5 46.8 10.9 BMI 27.1 2.3 control (CT). All participants underwent a 5-day modified fasting therapy introduced with 2-day moderate calorie...

Treatment with cisplatin (DDP) is one of the standard therapies used to treat non-small-cell lung cancer (NSCLC) and fundamentally causes resistance in cells, which eventually poses as an obstacle efficacy chemotherapy NSCLC. Efforts are on all over world explore a sensitizer NSCLC DDP. Here, we studied effect IL-7 chemotherapy. We observed that treatment significantly enhanced DDP-induced effects A549 A549/DDP cells (DDP-resistant cells), including decreased cell viability proliferation,...

ADAM-like decysin-1 (ADAMDEC1) has been reported to play an important role in the pathogenesis of multiple diseases, including cancers. However, its biological non-small cell lung cancer (NSCLC) remains largely unknown. Here, we aimed investigate functions and potential mechanism ADAMDEC1 NSCLC.We verified as a DEG by comprehensive strategy TCGA GEO datasets miming computational biology. Relative levels NSCLC tissues adjacent peritumoral were identified qRT-PCR, WB IHC staining. The function...

Abstract There is continued interest in the assessment and potential use of antioxidants as neuroprotective agents diseases associated with increased oxidative stress, such Parkinson's disease. The effect a natural antioxidant drink, EM-X (a ferment derivative unpolished rice, papaya seaweeds effective microorganisms), was investigated using 6-hydroxydopamine (6-OHDA)-lesion rat model nigrostriatal dopaminergic neurons were unilaterally lesioned 6-OHDA (8 μg) rats that treated 10-times...

To observe the protective effects of modified Linggui Zhugan Decoction combined with short-term very low calorie diets (VLCDs) on cardiovascular risk factors in obese patients impaired glucose tolerance (IGT). Eighty-five IGT spleen hypofunction and dampness accumulation type were randomly divided into treated group (n=45) control (n=40). The was given VLCDs. basic weight-reduction treatment. total course 6 months. Changes fasting plasma (FPG), 2-hour postprandial blood (2hPG), glycosylated...

Recent studies suggest that peripheral nerve injury converts resting spinal cord astroglial cells into an activated state, which is required for the development and maintenance of neuropathic pain. However, underlying mechanisms how astrocytes are after remain largely unknown. Astroglial cell proliferation activation could be affected by endogenous factors including chemokines, growth factors, neurotropic factor. Chemokine (C-C motif) ligand 7 (Ccl7) essential in facilitating pain; however,...

High body mass index- (BMI-) related vascular injury contributes to the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Rigorous calorie restriction is one major lifestyle interventions reduce risk in overweight or obese individuals. However, effects fasting therapy (FT) on function and mechanism are still unclear. This study was aimed investigate impacts FT endothelial function, arterial stiffness, circulating damage parameters individuals possible mechanism.Overweight...

Abstract Background Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because common high-calorie diet and sedentary lifestyle. This study aimed to evaluate role CR T2DM further explore its potential molecular mechanisms. Methods Sixty male Sprague–Dawley rats were used this study. The model was induced by 8 weeks high-fat (HFD) followed a single dose streptozotocin injection (30 mg/kg). Subsequently, diabetic fed HFD at 28 g/day...

To evaluate the effects of modified Linggui Zhugan Decoction () combined with short-term very low calorie diets (VLCDs) on glycemic control in newly diagnosed type 2 diabetes mellitus (T2DM) patients. A total 20 subjects T2DM were treated (one-month administration) VLCDs (5 days), and 3-months follow-up. standard 75-g oral-glucose-tolerance test (OGTT) indexes fasting plasma glucose (FPG), post-prandial 0.5 h (P0.5hPG, P2hPG), glycated hemoglobin A1C (GHbA1C), body weight, mass index (BMI),...

To assess the therapeutic effect of weekend fasting and administration a modified Lingguizhugan decoction on metabolic syndrome (MetS).Twenty-one patients with MetS were recruited from First Affiliated Hospital Sun Yat-Sen University. Fasting plasma glucose (FPG), 30-min 2-h post-prandial blood (PG), serum insulin (FINS), pressure (BP), body mass index (BMI), waist circumference (WC), homeostasis model assessment for resistance (HOMA-IR), levels triglyceride (TG), total cholesterol (TC),...

Abstract Objectives The chemotherapy drug resistance is a major challenge for non‐small‐cell lung cancer (NSCLC) treatment. Combination of immunotherapy and has shown promise cancer. goal this study was to evaluate the anti‐tumour efficacy interleukin‐7 (IL‐7) combining cisplatin against NSCLC. Materials Methods Cell proliferation analysed using CCK‐8 assay, EdU assay colony‐forming assay. apoptosis evaluated HOECHST 33342 flow cytometry. protein expression levels were by Western blot....

Background:The ChaiShao Shugan Formula (CSSGF) is a traditional Chinese medicine formula with recently identified therapeutic value in triple-negative breast cancer (TNBC).This study aimed to elucidate the underlying mechanism of CSSGF TNBC treatment.Methods: targets were analyzed using R and data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases.The major ingredients related protein explored via Traditional Medicine Systems Pharmacology database, an...

The mortality rate of non-small-cell lung cancer (NSCLC) remains high worldwide. Although cisplatin-based chemotherapy may greatly enhance patient prognosis, resistance an obstacle to curing patients with NSCLC. Therefore, overcoming drug is the main route successful treatment, and combinatorial strategies have considerable clinical value in this effort. In study, we observed that both parthenolide (PTL) cisplatin (DDP) inhibited growth NSCLC cells a dose- time-dependent manner. combination...