A5053053962- Dietary Effects on Health
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Nanoparticles: synthesis and applications
- Traditional Chinese Medicine Studies
- Regulation of Appetite and Obesity
- Alzheimer's disease research and treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Nutritional Studies and Diet
- Nanocluster Synthesis and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Advanced Glycation End Products research
- Hepatitis B Virus Studies
- Biochemical effects in animals
- Gut microbiota and health
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
The Seventh Affiliated Hospital of Sun Yat-sen University
2019-2024
Sun Yat-sen University
2018-2024
Shanghai University of Medicine and Health Sciences
2020
The First Affiliated Hospital, Sun Yat-sen University
2018-2020
Second Military Medical University
2019
Wenzhou Medical University
2011
Obesity is a major risk factor for variety of diseases such as diabetes, nonalcoholic fatty liver disease, and cardiovascular diseases. Restricting energy intake, or caloric restriction (CR), can reduce body weight improve metabolic parameters in overweight obese patients. We previously found that Lingguizhugan decoction (LZD) combination with CR effectively lower plasma lipid levels patients syndrome. However, the mechanism underlying LZD treatment still unclear.To investigate whether by...
High body mass index- (BMI-) related vascular injury contributes to the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Rigorous calorie restriction is one major lifestyle interventions reduce risk in overweight or obese individuals. However, effects fasting therapy (FT) on function and mechanism are still unclear. This study was aimed investigate impacts FT endothelial function, arterial stiffness, circulating damage parameters individuals possible mechanism.Overweight...
Abstract Background Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because common high-calorie diet and sedentary lifestyle. This study aimed to evaluate role CR T2DM further explore its potential molecular mechanisms. Methods Sixty male Sprague–Dawley rats were used this study. The model was induced by 8 weeks high-fat (HFD) followed a single dose streptozotocin injection (30 mg/kg). Subsequently, diabetic fed HFD at 28 g/day...
Parkinson's disease (PD) characterized by inflammation and protein erroneous deposition, whose pathological mechanisms have not been elucidated. NcRNA plays important role in PD, especially when circRNA sponges miRNA, which leads to the breakdown of downstream regulation. The aim this study is investigate dynamic changes between upregulated downregulated miRNA during pathogenesis PD their impact on targets. We conducted bioinformatics sequencing data substantia nigra (SN) striatum,...
Abstract Objective The aim of this study was to evaluate the efficacy and safety modified fasting therapy, a retrospective conducted analyze changes in clinical indicators hospitalized patients. Methods A total 2054 patients were enrolled observational study. All participants underwent 7 days therapy. biomarkers, indicators, body composition measured before after fasting. Results therapy reduced weight, BMI, abdominal circumference, systolic blood pressure, diastolic pressure significantly....
<title>Abstract</title> <bold>Objective</bold>: This study aimed to develop a matrix prediction model based on weight loss and improvement in CVD risk factors evaluate the cardiovascular benefits of modifiedfasting therapyin overweight/obese patients with hyperglycemia.<bold>Methods</bold>: CVD-related clinical predictors were extracted from group 3449 hospitalizedindividuals after therapy using logistic regression. Matrix models formulated, corresponding scoring system was developed...
Gold nano rods (GNRs) have showed cytotoxicity to cancer cells. At the same time, it shows little effects on non-tumor Between GNRs and sub-cellular organelles, understanding of interaction plays a very important role determine intracellular mechanisms. The purpose what we done is explain surface properties specific cell death. Three GNR samples with different aspect ratios were finely prepared by seed-mediated growth method. Then transport in vitro/vivo mechanisms death studied transmission...
The passive targeting via nanomedicine to pancreatic tumor microenvironment (TME) is identified as an optimized therapeutic strategy for ductal adenocarcinoma (PDAC) because lacking specific biomarkers and the intractable anatomical position. Herein, in vitro 3D PDAC model was set up evaluate regulation of extracellular matrix (ECM) by intelligent nanogel system. This system consisting a reduction-sensitive core, payloads gemcitabine, coronal hyaluronidase fabricated improve intratumoral...
Abstract Background Caloric restriction (CR), as the only approved scientific method that can retard aging, has become more and attractive in treatment of type 2 diabetes mellitus (T2DM) due to increasingly common high calorie diet sedentary lifestyle. This study aimed evaluate its role T2DM further explored potential molecular mechanism. Methods A total 60 male SD rats were used this study. Diabetes model was induced by 8 weeks high-fat (HFD) followed a single dose streptozotocin injection...
Abstract Background Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because common high-calorie diet and sedentary lifestyle. This study aimed to evaluate role CR T2DM further explore its potential molecular mechanisms. Methods Sixty male Sprague-Dawley rats were used this study. The model was induced by 8 weeks high-fat (HFD) followed a single dose streptozotocin injection (30 mg/kg). Subsequently, diabetic fed HFD at 28 g/day...