A5054783121- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Diet and metabolism studies
- Hepatitis B Virus Studies
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
- Mitochondrial Function and Pathology
- Nutritional Studies and Diet
- Currency Recognition and Detection
- Liver Disease and Transplantation
- Traditional Chinese Medicine Studies
- Diet, Metabolism, and Disease
- Mast cells and histamine
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Dietary Effects on Health
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Pediatric Hepatobiliary Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- 3D Printing in Biomedical Research
The Seventh Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Radboud University Medical Center
2021
Radboud University Nijmegen
2021
Radboud Institute for Molecular Life Sciences
2021
ORCID
2021
Erasmus MC
2017-2020
Nankai University
2019-2020
Ministry of Education of the People's Republic of China
2019
Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics mitochondria, comprised fusion fission processes, are closely associated with mitochondrial functions often dysregulated In this study, we aim to investigate its functional consequences human liver We observed excessive activation tumor tissues from hepatocellular carcinoma (HCC) patients vitro cultured organoids cholangiocarcinoma (CCA). knockdown regulator...
Rotavirus infection has emerged as an important cause of complications in organ transplantation recipients and might play a role the pathogenesis inflammatory bowel disease (IBD). 6-Thioguanine (6-TG) been widely used immunosuppressive drug for treatment IBD clinic. This study aims to investigate effects mode-of-action 6-TG on rotavirus replication. Human intestinal Caco2 cell line, 3D model human primary organoids, laboratory strain (SA11) patient-derived isolates were used. We have...
The outcomes of hepatitis E virus (HEV) infection are diverse, ranging from asymptomatic carrier, self-limiting acute infection, and fulminant to persistent infection. This is closely associated with the immunological status host. study aimed understand innate cellular immunity as first-line defense mechanism in response HEV Phosphorylation signal transducer activator transcription 1, a hallmark activation antiviral interferon (IFN) response, was observed liver tissues majority HEV-infected...
Unhealthy diets contribute to the onset and progression of chronic kidney disease (CKD), with poor dietary habits identified as significant lifestyle factors that elevate CKD risk. Data from UK Biobank cohort, which included over 500,000 participants aged 40–69 diverse regions England, Wales, Scotland, were analyzed. Participants, who completed at least one online 24-hour recall assessment, in study. The baseline for analysis was first 2011, follow-up extending until earliest occurrence...
Abstract Background Type 2 diabetes is associated with a variety of complications, including micro- and macrovascular neurological manifestations poor wound healing. Adhering to Mediterranean Diet (MED) generally considered an effective intervention in individuals at risk for type mellitus (T2DM). However, little known about its effect respect the different specific T2DM. This prompted us explore MED on three most significant microvascular complications T2DM: diabetic retinopathy (DR),...
Hepatitis E virus (HEV) infection has emerged as a global health issue, but no approved medication is available. The nucleoside analogue 2'-C-methylcytidine (2CMC), viral polymerase inhibitor, been shown to inhibit with variety of viruses, including hepatitis C (HCV). Here, we report that 2CMC significantly inhibits the replication HEV in subgenomic model and system using full-length infectious virus. Importantly, long-term treatment did not result loss antiviral potency, indicating high...
ABSTRACT Hepatitis E virus (HEV) infection has emerged as a global health problem. However, no approved medication is available, and the biology remains largely elusive. Electron transport chain (ETC), key component of mitochondria, main site that produces ATP reactive oxygen species (ROS). By profiling role different complexes mitochondrial ETC, we found pharmacological inhibition complex III, well‐defined drug target for treatment malaria Pneumocystis pneumonia, potently restricts HEV...
Enteric viruses including hepatitis E virus (HEV), human norovirus (HuNV), and rotavirus are causing global health issues. The host interferon (IFN) response constitutes the first-line defense against viral infections. Melanoma Differentiation-Associated protein 5 (MDA5) is an important cytoplasmic receptor sensing infection to trigger IFN production, on other hand it also IFN-stimulated gene (ISG). In this study, we investigated effects mode-of-action of MDA5 enteric viruses. We found that...
Abstract Hepatitis E virus (HEV) as an emerging zoonotic pathogen causes a major public health issue. Transmission from domestic, wildlife and zoo animals to human has been widely reported. Whether pets also serve reservoirs remains intriguing question. In this study, we found the sero-positive rates of HEV-specific antibodies in pet dogs, cats horses 18.52% (30/162), 14.89% (7/47) 18.18% (4/22) Netherlands. Although HEV viral RNA was not detected these animals, have demonstrated that dog...
Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide and can develop into chronic in immunocompromised patients, promoting development effective antiviral therapies. In this study, we performed a screening library containing over 1000 FDA-approved drugs. We have identified deptropine, classical histamine H1 receptor antagonist used to treat asthmatic symptoms, as potent inhibitor HEV replication. The anti-HEV activity deptropine appears dispensable pathway, but...
<title>Abstract</title> <bold>Objective</bold>: This study aimed to develop a matrix prediction model based on weight loss and improvement in CVD risk factors evaluate the cardiovascular benefits of modifiedfasting therapyin overweight/obese patients with hyperglycemia.<bold>Methods</bold>: CVD-related clinical predictors were extracted from group 3449 hospitalizedindividuals after therapy using logistic regression. Matrix models formulated, corresponding scoring system was developed...
Abstract The absence of effective extracellular matrix to mimic the natural tumor microenvironment remains a significant obstacle in cancer research. Matrigel, abundant various biological components, is limited its application due high cost. This has prompted researchers explore alternative substitutes. Here, we have investigated effects derived from pig small intestinal submucosa (ECM-SIS) xenograft modeling. Our results showed that pig-derived ECM-SIS effectively promotes establishment...