A5057036130- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- interferon and immune responses
- Liver Disease and Transplantation
- Seaweed-derived Bioactive Compounds
- Medical and Biological Ozone Research
- Mosquito-borne diseases and control
- Adrenal and Paraganglionic Tumors
- RNA modifications and cancer
- RNA Research and Splicing
- Meningioma and schwannoma management
- Vitamin C and Antioxidants Research
- Veterinary medicine and infectious diseases
- Heat shock proteins research
- Esophageal and GI Pathology
- Parathyroid Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
Xiangtan University
2025
Zhejiang University
2018-2024
South China Agricultural University
2022-2024
First Affiliated Hospital Zhejiang University
2022
Institute of Animal Sciences
2019
Nanjing University of Chinese Medicine
2015
Jiangsu Province Hospital
2015
Jiangning District of Nanjing Chinese Medicine Hospital
2015
Victorian Infectious Diseases Reference Laboratory
2010
Nagano Red Cross Hospital
2010
Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to an understanding pathogenesis and development intervention strategies. The fourth CoV genus, Deltacoronavirus, evolutionarily related Gammacoronavirus, has just been defined recently. In current study, we demonstrate that porcine aminopeptidase N (pAPN) acts as a cross-genus functional receptor for both enteropathogenic deltacoronovirus (PDCoV) alphacoronovirus (AlphaCoV) (transmissible...
Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PEDV), causes high mortality neonatal piglets worldwide. To determine the biological role of nsp2, we generated a PEDV mutant containing complete nsp2 deletion (rPEDV-Δnsp2) from highly pathogenic strain by reverse genetics, showing that was dispensable for infection, deficiency reduced replication...
An aptamer-free paper-based MIPs sensor for the detection of H5N1 with naked eyes without any equipment were developed. And visual was achieved within 20 min.
Background/Aims: To investigate the effect of Astragaloside IV (AS-IV) on regulation TGF-β1/Smad signaling pathway in peritoneal mesothelial cells with an epithelial-to-mesenchymal transition (EMT). Methods: EMT human (HMrSV5) was induced using 2 ng/ml TGF-β1. Cells were randomly divided into a vehicle group, group AS-IV, TGF-β1 treated and receiving varied doses AS-IV or NAC. Real-time quantitative PCR western blot used to detect expression genes proteins associated EMT. DCFH-DA generation...
T cells require rapid proliferation to initiate adaptive immunity prevent pathogen attacks. The nucleolus, a distinct subnuclear membrane-less compartment for ribosomal biogenesis, is indispensable cell proliferation. However, specific nucleolar proteins involved in and their underlying molecular regulatory mechanism remain elusive. Here, we identified an essential protein, DCAF13, revealed its significant regulation of Its depletion drastically impairs due severe 18S rRNA maturation...
HEV infects >20 million people annually, causing acute viral hepatitis as well chronic hepatitis, neurological diseases, and pregnancy-associated high mortality, which require therapeutic intervention. The antiviral research is largely limited by the lack of a convenient small animal model.
Although feline coronavirus (FCoV) infection is extremely common in cats, there are currently few effective treatments. A peptide derived from the heptad repeat 2 (HR2) domain of (CoV) spike protein has shown for inhibition various human and animal CoVs vitro, but further use FCoV-HR2 vivo been limited by lack practical delivery vectors small model. To overcome these technical challenges, we first constructed a recombinant Bacillus subtilis (rBSCotB-HR2P) expressing spore coat B (CotB) fused...
Hepatocellular carcinoma (HCC) is a serious neoplastic disease with increasing incidence and mortality, accounting for 90% of all liver cancers. Hepatitis viruses are the major causative agents in development HCC. A virus (HAV) primarily causes acute infections, which associated HCC to certain extent, as shown by clinicopathological studies. Chronic hepatitis B (HBV) or C (HCV) infections lead persistent inflammation cirrhosis, disrupt multiple pathways cellular apoptosis proliferation, most...
Alphaviruses are mosquito borne RNA viruses that a reemerging public health threat. have broad host range, and can cause diverse disease outcomes like arthritis, encephalitis. The ubiquitin proteasome system (UPS) plays critical roles in regulating cellular processes to control the infections with various viruses, including alphaviruses. Previous studies suggest alphaviruses hijack UPS for virus infection, but molecular mechanisms remain poorly characterized. In addition, whether certain E3...
Alphaviruses are mosquito borne RNA viruses that a reemerging public health threat. have broad host range, and can cause diverse disease outcomes like arthritis, encephalitis. The ubiquitin proteasome system (UPS) plays critical roles in regulating cellular processes to control the infections with various viruses, including alphaviruses. Previous studies suggest alphaviruses hijack UPS for virus infection, but molecular mechanisms remain poorly characterized. In addition, whether certain E3...
A variety of swine enteric coronaviruses (SECoVs) have emerged and are prevalent in pig populations, including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis (TGEV), deltacoronavirus (PDCoV), acute syndrome (SADS)-CoV, a newly identified bat-origin CoV with zoonotic potential. Unfortunately, available traditional, inactivated attenuated SECoV vaccines limited efficacy against the variants currently circulating most populations. In this study, we evaluated role host...
The ongoing global healthcare challenge posed by COVID-19 necessitates the continuous quest for novel antiviral agents. Fucoidans have demonstrated activity. However, underlying structure-activity mechanism responsible inhibitory activity of fucoidans from Ascophyllum nodosum (FUCA) and Undaria pinnatifida (FUCU) against SARS-CoV-2 remains unclear. Here, we found that FUCA exhibited a higher uronic acid content (5.3%) than FUCU (<1%), while simultaneously demonstrating lower sulfate (22.6%...
Objective: To report the clinical manifestations, imaging characteristics, surgical approaches, management, and outcomes of jugular foramen tumors.