A5101564374- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Liver physiology and pathology
- Cardiac Ischemia and Reperfusion
- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Cardiovascular Function and Risk Factors
- Anesthesia and Neurotoxicity Research
- Glioma Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Pancreatitis Pathology and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Alcohol Consumption and Health Effects
- Nerve injury and regeneration
- Liver Disease and Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
Anhui Polytechnic University
2022-2025
Bengbu Medical College
2012-2024
St. Jude Children's Research Hospital
2012-2024
Schweizerisches Universitäres Institut für Traditionelle Chinesische Medizin
2023-2024
Shanghai Jiao Tong University
2014-2023
XinHua Hospital
2012-2023
Jiangsu Province Hospital
2014-2022
Shanghai First People's Hospital
2014-2022
Nanjing University of Chinese Medicine
2015-2022
Rutgers, The State University of New Jersey
2017-2020
To estimate the prevalence of and risk factors for growth hormone deficiency (GHD), luteinizing hormone/follicle-stimulating deficiencies (LH/FSHD), thyroid-stimulatin (TSHD), adrenocorticotropic (ACTHD) after cranial radiotherapy (CRT) in childhood cancer survivors (CCS) assess impact untreated deficiencies.
Abstract Liver fibrosis is the excessive accumulation of extracellular matrix proteins in response to inflammatory that accompanies tissue injury, which at an advanced stage can lead cirrhosis and even liver failure. This study investigated role CXC chemokine CXCL 6 ( GCP ‐2) fibrosis. The expression was found be elevated serum high patients. Furthermore, treatment with (100 ng/mL) stimulated phosphorylation EGFR TGF ‐β cultured Kupffer cells KC s). Although directly did not activate hepatic...
Co-culture engineering is an emerging approach for microbial biosynthesis of a variety biochemicals. In this study, E. coli-E. coli co-cultures were developed heterologous the natural product naringenin. The composed two independent strains dedicated to functional expression different portions biosynthetic pathway, respectively. co-culture was optimized by investigating effect carbon source, strain selection, timing IPTG induction and inoculation ratio between strains. Compared with...
Abstract Context Data on hypothalamic-pituitary (HP) disorders in systematically evaluated childhood cancer survivors are limited. Objective To describe prevalence, risk factors, and associated adverse health outcomes of deficiencies GH deficiency (GHD), TSH (TSHD), LH/FSH (LH/FSHD), ACTH (ACTHD), central precocious puberty (CPP). Design Retrospective with cross-sectional analysis. Setting Established cohort; tertiary care center. Patients Participants (N = 3141; median age, 31.7 years) were...
Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease
Although the underlying mechanisms of diabetes-induced myocardial injury have not been fully illuminated, inflammation reaction has reported intently linked with diabetes. The nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, key component pyroptosis, is involved in reaction, which may be one important injury. purpose this study was to investigate changes NLRP3 inflammasome and pyroptosis high glucose-induced H9C2 cardiac cell whether overexpression...
Diabetic cardiomyopathy (DCM) is a chronic disease caused by diabetes mellitus, which recognized as worldwide challenging disease. This study aimed to investigate the role and potential mechanism of knocking down NACHT-, LRR- PYD domains-containing protein 3 (NLRP3), an inflammasome associated with onset progression various diseases, on high glucose or -induced cardiac cells pyroptosis ferroptosis, two regulated non-necrosis cell death modalities discovered recent years. In present study,...
Background/Aims: To investigate the effect of Astragaloside IV (AS-IV) on regulation TGF-β1/Smad signaling pathway in peritoneal mesothelial cells with an epithelial-to-mesenchymal transition (EMT). Methods: EMT human (HMrSV5) was induced using 2 ng/ml TGF-β1. Cells were randomly divided into a vehicle group, group AS-IV, TGF-β1 treated and receiving varied doses AS-IV or NAC. Real-time quantitative PCR western blot used to detect expression genes proteins associated EMT. DCFH-DA generation...
Objective . The present study was designed to determine whether dexmedetomidine (DEX) exerts cardioprotection against myocardial I/R injury in diabetic hearts and the mechanisms involved. Methods A total of 30 rats induced by high-glucose-fat diet streptozotocin (STZ) were randomly assigned five groups: sham-operated group (DM-S), (DM-I/R), DEX (DM-D), + Wort (DM-DW), (DM-W). Another 12 age-matched male normal SD divided into two (S) (I/R). All subjected min ischemia followed 120 reperfusion...
Direct assessment of Leydig cell function in childhood cancer survivors has been limited. The objectives this study were to describe the prevalence and risk factors for failure (LCF), dysfunction (LCD), associated adverse health outcomes.In retrospective with cross-sectional outcomes analysis, we evaluated 1,516 participants (median age, 30.8 years) at a median 22.0 years after diagnosis. LCF was defined as serum total testosterone less than 250 ng/dL (or 8.67 nmol/L) luteinizing hormone...
Non-small cell lung cancer (NSCLC) is considered to be one of the most prevalent and fatal malignancies, with a poor survival rate. Chimeric antigen receptor T (CAR-T) therapy exciting directions in field Cellular immunotherapy. Therefore, CAR-T cells that target c-Met have been developed for use NSCLC might potential therapeutic strategy. The anti scFv structure was fused transmembrane intracellular domains. Using lentiviral vector load CAR gene, then transfected into human obtain second...
Abstract Background To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) underlying molecular mechanism. Methods Bioinformatics analyses were performed transcriptome data liver tissues from mice patients with for screening pyroptosis-related differential genes. The vivo NASH mouse model vitro cellular established. expression levels Anxa2/ ANXA2 quantified. Then, upstream transcription factor Anxa2 was screened by...
(1) Background: At the time of harvest, stems broccoli are frequently discarded. (2) Methods: In this study, sulforaphane content and glucosinolate profile were analyzed at different temperature treatments. (3) Results: Thermal treatment for 1 h resulted in maximal 50 °C, with a subsequent progressive reduction concentration correlating to elevated temperatures. Metabolomic analysis was conducted on stem samples subjected 25 °C (CK), 80 Among identified GSLs, °C-treated demonstrated...
Inflammation and transforming growth factor-β1 (TGF-β1) contribute to the development of peritoneal fibrosis (PF), which is associated with dialysis (PD). Astragalus membranaceus (Astragalus) has anti-inflammatory anti-fibrotic effects in many diseases. The goal this study was determine on PF response PD. A rat model PD induced using standard fluid, verified by HE Masson’s staining, as well through expression fibroblast surface protein (FSP) collagen III. levels monocyte chemoattractant...
Our study aimed firstly to observe whether ALDH2 was expressed in neonate rat cardiac fibroblasts, then investigate the effect of activation on oxidative stress, apoptosis, and fibrosis when fibroblasts were subjected high glucose intervention. Cultured randomly divided into normal (NG), NG + Alda‐1, (HG), HG Alda‐1 daidzin, hypertonic groups. Double‐label immunofluorescence staining, RT‐PCR, Western blot revealed fibroblasts. Compared with NG, activity protein expression reduced, fibroblast...
Abstract Microbial biosynthesis has been extensively adapted for the production of commodity chemicals using renewable feedstocks. This study integrated metabolite biosensors into rationally designed microbial cocultures to achieve high‐efficiency bioproduction phenol from simple carbon substrate glucose. Specifically, two sets E. coli–E. coli were first constructed accommodation independent pathways via 4‐hydroxybenzoate (4HB) and tyrosine (TYR), respectively. Biosensor‐assisted cell...
The aim of the present study was to investigate whether necroptosis occurs in high glucose (HG)-induced H9c2 cardiac cell injury and activation aldehyde dehydrogenase 2 (ALDH2) can inhibit necroptosis. cells were treated with 35 mM establish a HG‑induced model. Alda‑1 (20 µM), specific activator ALDH2 necrostatin‑1 (Nec‑1, 100 an inhibitor used treat under HG conditions. Cell viability measured using Counting Kit‑8 assay reactive oxygen species (ROS) generation by dihydroethidium staining...
Endomorphins (EMs) have important roles in the body with regards to analgesia, feeding behavior, gastrointestinal movement and inflammatory reaction. Recent studies reported that EMs may also participate chronic hypoxia protection of rat myocardial ischemia/reperfusion; however, mediator underlying mechanisms remain be elucidated. The aim present study was investigate effects EM‑1 postconditioning on ischemia/reperfusion injury (MIRI) cell apoptosis a model, assess its likely mechanisms. A...