A5053216349- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Acute Lymphoblastic Leukemia research
- BRCA gene mutations in cancer
- Testicular diseases and treatments
- Reproductive Biology and Fertility
- Nutrition and Health in Aging
- Thyroid and Parathyroid Surgery
- Palliative Care and End-of-Life Issues
- Adrenal and Paraganglionic Tumors
- Congenital Diaphragmatic Hernia Studies
- Regulation of Appetite and Obesity
- Genetics and Neurodevelopmental Disorders
- Head and Neck Anomalies
- Diet and metabolism studies
- Bone health and osteoporosis research
- Neonatal Health and Biochemistry
- Family Support in Illness
- Global Cancer Incidence and Screening
Princess Máxima Center
2016-2025
University Medical Center Utrecht
2016-2025
Wilhelmina Children's Hospital
2016-2025
Utrecht University
2019-2024
University of Groningen
2021
Dialyse Centrum Groningen
2021
Emma Kinderziekenhuis
2006-2020
University Medical Center Groningen
2020
Radboud University Nijmegen
2020
Radboud University Medical Center
2020
At present, no European recommendations for the management of pediatric thyroid nodules and differentiated carcinoma (DTC) exist. Differences in clinical, molecular, pathological characteristics between adult DTC emphasize need specific population. An expert panel was instituted by executive committee Thyroid Association including an international community experts from a variety disciplines endocrinology, pathology, endocrine surgery, nuclear medicine, clinical genetics, oncology. The 2015...
Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 2012, survived ≥ 2 years after diagnosis. with craniopharyngeoma or a pituitary gland excluded. Results all investigations, which performed at diagnosis during follow-up, collected from patient charts. Multivariable logistic regression was used to associations...
Childhood cancer survivors face late health problems; despite advances in research, details on risk remain unclear. We describe the methodological aspects of Dutch Cancer Survivor Study (DCCSS) cross-sectional clinical study (LATER 2 study).From multi-center DCCSS LATER cohort 6165 five-year diagnosed during 1963-2001, we invited 4735 eligible 2016, as well siblings and parents survivors. Gaps evidence identified development surveillance guidelines were translated into research questions for...
Hypothalamic syndrome (HS) in childhood is a rare condition. Its epidemiology not well known because incidence and prevalence are related to very underlying diseases. In addition, different criteria for the used across studies. Recognizing HS may be difficult, due its rareness variety of symptoms. Having diagnostic signs symptoms hypothalamic dysfunction aid early recognition diagnosis, reporting understanding etiology, predicting course management. We aimed define score presence...
Abstract Context Data on hypothalamic-pituitary (HP) disorders in systematically evaluated childhood cancer survivors are limited. Objective To describe prevalence, risk factors, and associated adverse health outcomes of deficiencies GH deficiency (GHD), TSH (TSHD), LH/FSH (LH/FSHD), ACTH (ACTHD), central precocious puberty (CPP). Design Retrospective with cross-sectional analysis. Setting Established cohort; tertiary care center. Patients Participants (N = 3141; median age, 31.7 years) were...
Treatment for differentiated thyroid carcinoma (DTC) in pediatric patients is based mainly on evidence from adult series due to lack of data cohorts. Our objective was evaluate presentation, treatment-related complications, and long-term outcome with DTC The Netherlands.In this nationwide study, (age at diagnosis ≤18 y) treated Netherlands between 1970 2013 were assessed using medical records.We identified 170 patients. Overall survival 99.4% after a median follow-up 13.5 years (range...
Children with acquired hypothalamic obesity, e.g. following treatment for pediatric craniopharyngioma are at great risk metabolic syndrome, cardiovascular health problems and premature mortality. Treatment obesity has thus far been disappointing. Several interventions were reported to be partially successful, including dextro-amphetamine GLP-1R agonists, although results in conflicting. Disruption of signaling through the melanocortin-4 receptor (MC4R) pathway hyperphagia severe early-onset...
There is an unexplained higher incidence of congenital hypothyroidism (CH) detected by T(4)-based neonatal screening programs and a very high prevalence (mild) plasma TSH elevation in young children with Down syndrome (DS). To determine whether newborns DS have decreased blood T(4) concentrations at the time screening, we conducted observational study large representative cohort Dutch born 1996 1997. CH results (T(4), TSH, T(4)-binding globulin concentrations) were analyzed comparison...
Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) children neuroblastoma (NBL), despite the use potassium-iodide (KI). Our aim was investigate if incidence and severity thyroid damage increases time.All long-term survivors childhood NBL treated I-MIBG period 1989-1999 our center (n = 16 43) were evaluated. During exposure I-MIBG, received 100 mg KI per day as protection. All MIBG images evaluated for uptake...