A5003025213- Diet and metabolism studies
- Diabetes Management and Research
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Childhood Cancer Survivors' Quality of Life
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Nutrition, Genetics, and Disease
- Reproductive Biology and Fertility
- Adipokines, Inflammation, and Metabolic Diseases
- Sexual Differentiation and Disorders
- Digestive system and related health
- Metabolism, Diabetes, and Cancer
- Obesity and Health Practices
- Eating Disorders and Behaviors
- Child and Adolescent Health
Universität Ulm
2013-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2005-2024
University Hospital Ulm
2013-2024
Inserm
2023
Centre Hospitalier Universitaire de Montpellier
2023
Université de Montpellier
2023
Universitätskinderklinik
2019
University of Nevada, Las Vegas
2003
Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective present study was to investigate association hepatic steatosis.Data from 2,445 subjects (51.7% females) aged 18 65 years participating in population-based cross-sectional were assessed based on standardized questionnaire documentation physical, biochemical ultrasonographic findings. After application exclusion...
Congenital leptin deficiency is a very rare cause of severe early-onset obesity. We recently characterized mutation in the gene (p.D100Y), which was associated with detectable levels and bioinactivity hormone. now describe two siblings, 9-year-old girl 6-year-old boy obesity hyperphagia, both homozygous for c.309C>A substitution leading to p.N103K amino acid exchange protein circulating leptin. In vitro experiments heterologous cell system demonstrated that mutated biologically inactive....
Nonalcoholic fatty liver disease (NAFLD) is known to have a gender-dimorphic prevalence in obese children. Less information available on predictive factors for NAFLD youths.The aim of the study was examine pattern and identify clinical laboratory markers associated with risk NAFLD.This cross-sectional study.The setting rehabilitation clinic.A total 532 subjects (291 girls) aged 8-19 yr participated study.Steatosis hepatis visceral fat mass were determined by ultrasound. Laboratory tests...
Objective Recent literature suggests an association between type 1 diabetes (T1D) and depression. So far, most studies explored this link in adult populations, with few data being available on depression from minors young adults. This study aimed to look for associations symptoms of depression/antidepressant treatment metabolic outcomes T1D. Methods We conducted observational using the German database (Diabetes-Patienten-Verlaufsdokumentation – DPV) searched patients up age 25 yr, depressive...
Abstract Aim The aim of this official guideline published by the German Society Gynecology and Obstetrics (DGGG) coordinated with Urology (DGU) Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained evaluating relevant literature, on counseling fertility preservation for prepubertal girls boys as well patients reproductive age. Statements recommendations women are presented below. or men not focus guideline. Methods This S2k was developed at suggestion...
Children with acquired hypothalamic obesity, e.g. following treatment for pediatric craniopharyngioma are at great risk metabolic syndrome, cardiovascular health problems and premature mortality. Treatment obesity has thus far been disappointing. Several interventions were reported to be partially successful, including dextro-amphetamine GLP-1R agonists, although results in conflicting. Disruption of signaling through the melanocortin-4 receptor (MC4R) pathway hyperphagia severe early-onset...
ABSTRACT Objective Survivors of childhood, adolescent, and young adult (CAYA) cancer have an increased risk metabolic syndrome (MetS). MetS describes the clustering cardiovascular factors including overweight or obesity, hypertension, impaired glucose tolerance, hyperlipidaemia. While associated sequelae can be serious, is preventable, manageable potentially reversible with appropriate pharmacological and/or behavioral interventions. To optimise health outcomes in CAYA survivors,...
Background Increasing evidence link sleep curtailment and circadian misalignment with adverse metabolic outcome. Adolescents might be most affected, given their late timing early school work start times. Objective Our aim was to examine the impact of poor sleeping habits on glycemic control in adolescents type 1 diabetes. Subjects Methods This a non-interventional multicenter study across Germany recruiting pubertally mature Medical records were used collect information diabetes duration,...
Summary Background Overt or subclinical hypothyroidism is a common finding in adult populations affected by non‐alcoholic fatty liver disease (NAFLD). Currently, there are only sparse data available on the association of thyroid dysfunction and NAFLD obese children adolescents. Objective The study aims to investigate function test values with metabolic risk factors population Methods A total 332 overweight adolescents (170 girls) aged between 10 19 years were analysed. Subjects underwent...
Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical psychosocial effects. To improve appropriate timely endocrine screening referral to a specialist, the International Late Effects Childhood Cancer Guideline Harmonization Group (IGHG) aims develop evidence expert consensus-based guidelines for healthcare providers that harmonize recommendations surveillance CAYA cancer survivors. Existing IGHG premature...
OBJECTIVE We investigated the incidence of pediatric type 2 diabetes (T2D) in Germany during years coronavirus disease 2019 (COVID-19) pandemic (2020–2021) compared with control period 2011–2019. RESEARCH DESIGN AND METHODS Data on T2D children (aged 6 to <18 years) were obtained from DPV (German Diabetes Prospective Follow-up) Registry. Poisson regression was used estimate incidences for 2020 and 2021 based data 2011 2019, these observed by estimating rate ratios (IRRs) 95% CIs....
Recent epidemiological evidence suggests that subclinical hypothyroidism (SCH), defined as elevated TSH concentrations with normal circulating levels of triiodothyronine (T3) and thyroxine (T4), is associated dyslipidemia cardiovascular disease in adult populations. As currently no data are available on the prevalence SCH its potential association lipoprotein profile children adolescents type 1 diabetes (T1DM), we investigated lipid young diabetic patients.Cross-sectional analysis 22,747...
Summary Objectives The liver‐specific miR‐122 was proposed as biomarker for NAFLD in adults. Here, we investigated the relationship between levels, parameters of liver metabolism and pre‐pubertal obese children. Methods Parameters (ALT, AST GGT) three European cohorts were included (German cohort [ n = 71; age: 11.53 ± 1.29 years; BMI z‐score: 2.96 0.64], Italian 45; 9.60 2.11 3.57 1.16], Slovenian 31; 7.53 1.47 3.66 0.88]). MiR‐122 levels CK18 concentrations measured fasting blood samples....
<b><i>Background:</i></b> A limited number of published case reports suggest a positive effect dextroamphetamine, an adrenergic agonist affecting both the central nervous system (CNS) and peripheral system, on physical activity weight in patients with hypothalamic obesity (intractable following CNS insult). Here, we present our clinical experience dextroamphetamine treatment for obesity. <b><i>Methods:</i></b> The course all started severe at...