A5047833936- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Childhood Cancer Survivors' Quality of Life
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Celiac Disease Research and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Biochemical Analysis and Sensing Techniques
- Cystic Fibrosis Research Advances
- Regulation of Appetite and Obesity
- Digestive system and related health
- Lipoproteins and Cardiovascular Health
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine Tumor Research Advances
- Heart Rate Variability and Autonomic Control
- Advanced Glycation End Products research
- Nitric Oxide and Endothelin Effects
- Diet, Metabolism, and Disease
- Growth Hormone and Insulin-like Growth Factors
- Immunodeficiency and Autoimmune Disorders
Ljubljana University Medical Centre
2016-2025
University of Ljubljana
2011-2025
Boston Children's Hospital
2012-2015
University Hospital Cologne
2015
University of Cologne
2015
Temple Street Children's University Hospital
2015
Uniwersytecki Szpital Dziecięcy
2014-2015
Children's Clinical University Hospital
2014-2015
Očesna Klinika UKC Ljubljana
2015
Diabetes Australia
2010-2015
To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes.In this randomized, controlled, multicenter study, 120 children and adults intensive therapy for diabetes a screening level glycated hemoglobin A(1c) (HbA(1c)) <7.5% were randomly assigned to control group performing conventional home blood meter wearing masked monitor every second week five days or real-time monitoring. The primary outcome was time spent (interstitial concentration <63...
Recent studies have shown that an artificial-pancreas system can improve glucose control and reduce nocturnal hypoglycemia. However, it is not known whether such results be replicated in settings outside the hospital.In this multicenter, multinational, randomized, crossover trial, we assessed short-term safety efficacy of artificial pancreas for levels patients (10 to 18 years age) with type 1 diabetes at a camp. In two consecutive overnight sessions, randomly assigned 56 receive treatment...
Against a background of near-universally increasing incidence childhood type 1 diabetes, recent reports from some countries suggest slowing in this increase. Occasional also describe cyclical variations incidence, with periodicities between 4 and 6 years.Age/sex-standardised rates for the 0- to 14-year-old age group are reported 26 European centres (representing 22 countries) that have registered newly diagnosed individuals geographically defined regions up 25 years during period 1989-2013....
We evaluated the effect of MD-Logic system on overnight glycemic control at patients' homes.Twenty-four patients (aged 12-43 years; average A1c 7.5 ± 0.8%, 58.1 8.4 mmol/mol) were randomly assigned to participate in two crossover periods, each including 6 weeks consecutive nights: one under closed loop and second sensor-augmented pump (SAP) therapy homes real-life conditions. The primary end point was time spent with sensor glucose levels below 70 mg/dL (3.9 mmol/L) overnight.Closed-loop...
OBJECTIVE To investigate whether predictive low glucose management (PLGM) of the MiniMed 640G system significantly reduces rate hypoglycemia compared with sensor-augmented insulin pump in children type 1 diabetes. RESEARCH DESIGN AND METHODS This randomized, two-arm, parallel, controlled, two-center open-label study included 100 and adolescents diabetes glycated hemoglobin A1c ≤10% (≤86 mmol/mol) using continuous subcutaneous infusion. Patients were randomly assigned to either an...
Individuals with familial hypercholesterolemia (FH) who are untreated have up to 100-fold elevated risk for cardiovascular complications compared those unaffected. Data identification of FH a universal screening in children lacking.This study sought genetic from cohort serum total cholesterol (TC) concentration, detected national hypercholesterolemia.Slovenian born between 1989 and 2009 (n = 272) TC >6 mmol/l (231.7 mg/dl) or >5 (193.1 plus family history positive premature complications,...
Abstract Aims/hypothesis The aim of this work was to evaluate geographical variability and trends in the prevalence diabetic ketoacidosis (DKA), between 2006 2016, at diagnosis childhood-onset type 1 diabetes 13 countries over three continents. Methods An international retrospective study on DKA conducted. Data age, sex, date diagnosis, ethnic minority status presence onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia,...
Sensor-augmented pump (SAP) therapy can improve glycemic control, compared with multiple daily insulin injections or alone, without increasing the risk of hypoglycemia.
Artificial pancreas (AP) systems have shown an improvement in glucose control and a reduced risk of nocturnal hypoglycemia under controlled conditions but remain to be evaluated daily-life conditions.To assess the feasibility, safety, efficacy MD-Logic AP controlling levels patient's home.Two-arm study, each covering four consecutive nights comparing ('closed-loop' arm) with sensor-augmented pump therapy ('control' arm). Fifteen patients (mean age 19 ± 10.4 yr, A1c 7.5 0.5% or 58 5.9...
OBJECTIVE We evaluated the safety and efficacy of day-and-night fully closed-loop insulin therapy using faster (Faster-CL) compared with standard aspart (Standard-CL) in young adults type 1 diabetes. RESEARCH DESIGN AND METHODS In a double-blind, randomized, crossover trial, 20 participants diabetes on pump (11 females, aged 21.3 ± 2.3 years, HbA1c 7.5 0.5% [58.5 5.5 mmol/mol]) underwent two 27-h inpatient periods unannounced afternoon moderate-vigorous exercise unannounced/uncovered meals....
Rare homozygous or biallelic variants in POMC, PCSK1, and LEPR can disrupt signaling through the melanocortin-4 receptor (MC4R) pathway, resulting hyperphagia severe early-onset obesity. In pivotal Phase 3 clinical trials, treatment with MC4R agonist setmelanotide reduced hunger weight patients obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), leptin (LEPR) deficiency.To characterize historical trajectory these patients.This analysis included...
To assess the prevalence of underweight (UW), overweight (OW), and obesity in children adolescents with type 1 diabetes (T1D).An international cross-sectional study including 23 026 T1D (2-18 years, duration ≥1 year) participating SWEET prospective, multicenter registry. Body mass index SD score (BMI-SDS) was calculated using World Health Organization BMI charts. Children were categorized as UW (BMI-SDS < -2SD), OW (+1SD BMI-SDS ≤ +2SD), obese (OB) > +2SD). Hierarchic regression models...
Hypoglycaemia during and after exercise remains a challenge. The present study evaluated the safety efficacy of closed-loop insulin delivery unannounced (to algorithm) afternoon physical activity following night in young people with type 1 diabetes. A randomised, two-arm, open-label, in-hospital, crossover clinical trial was performed at single site Slovenia. order randomly determined using an automated web-based programme permuted blocks four. Allocation assignment not masked. Children...
Background: This study estimated temporal trends of metabolic control over 12 years in a national cohort childhood-onset type 1 diabetes. Subjects and Methods: Data from the prospective diabetes register, which included 886 case subjects 0 to 17.99 age at diagnosis least year follow-up until 22.99 years, were analyzed using multivariable linear logistic regression models observational period between 2000 2011. Results: Hemoglobin A1c (HbA1c) significantly decreased 78 mmol/mol (interquartile...
To evaluate physicians' adjustments of insulin pump settings based on continuous glucose monitoring (CGM) for patients with type 1 diabetes and to compare these automated dose adjustments.A total 26 physicians from 16 centres in Europe, Israel South America participated the study. All were asked adjust dosing pump, CGM glucometer downloads 15 (mean age 16.2 ± 4.3 years, six female, mean glycated haemoglobin 8.3 0.9% [66.8 7.3 mmol/mol]) gathered over a 3-week period. Recommendations compared...
This article reports on the lived experience of Medtronic advanced hybrid closed-loop (AHCL) in comparison to first generation (HCL) a randomized, open-label, two-period crossover trial. Patient-reported outcome (PROs) measures were administered before randomization and at end each study period 113 adolescents young adults with type 1 diabetes. Glucose monitoring satisfaction subscales for emotional burden behavioral improved significantly (P < 0.01) over time use AHCL versus HCL co-occurred...
Objective: To evaluate the use of faster acting (FIA) and standard insulin aspart (SIA) with hybrid automated delivery (AID) in active youth type 1 diabetes. Research Design Methods: In this double-blind multinational randomized crossover trial, 30 children adolescents diabetes (16 females; aged 15.0 ± 1.7 years; baseline HbA1c 7.5% 0.9% [58 9.8 mmol/mol]) underwent two unrestricted 4-week periods using AID either FIA or SIA random order. During both interventions, participants were...
Background Tight glucose control is needed to prevent long-term diabetes complications; this hindered by the risk of hypoglycemia, especially at night. Objective To assess safety and efficacy closed-loop MD-Logic Artificial Pancreas (MDLAP), controlling nocturnal levels in patients with type 1 mellitus (T1DM). Research design methods This was a randomized, multicenter, multinational, crossover trial conducted Slovenia, Germany, Israel. Twelve T1DM (age 23.8 ± 15.6 yr; duration 13.5 11.9 A1c...
Aims. This study assesses the impact of using an AP-system at home on fear hypoglycaemia. In addition, satisfaction and acceptance new technology are evaluated. Methods. a multicentre, multinational 75 patients MD-Logic AP during four consecutive nights in setting 59 them (aged 10–54 years, 54% male, HbA1c 7.89 ± 0.69% [62.72 7.51 mmol/mol], diabetes duration 11.6 8.4 yrs) answered standardized questionnaires (HFS, adapted TAM, satisfaction) before after AP. Results. After experiencing...
Shared susceptibility alleles in the HLA region contribute to co-existence of type 1 diabetes (T1D) and celiac disease (CD). The aim our study was identify genotype variations that influence co-occurrence T1D CD (T1D + CD) order their onset. Totally 244 patients, 67 with T1D, 68 69 CD, (split into "T1D first" "CD first"), were analyzed. Control group consisted 130 healthy unrelated individuals. Two-tailed Fisher's exact test used for statistical analysis. genetic background Slovenian...
This study explored the association between parental fear of hypoglycemia, anxiety, and subjective well-being in parents children adolescents with type 1 diabetes. A total 120 mothers 79 fathers participated. Mothers’ fathers’ hypoglycemia was significantly associated anxiety negative affect as well worse glycemic control child. Paired-samples t-test showed that were more involved diabetes management reported compared to fathers, but they did not differ worries about hypoglycemia. The...