A5037314810- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organ Transplantation Techniques and Outcomes
- Diabetes Management and Education
- Adipokines, Inflammation, and Metabolic Diseases
- Thermoregulation and physiological responses
- Growth Hormone and Insulin-like Growth Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Pharmaceutical studies and practices
- Electrochemical sensors and biosensors
- Regulation of Appetite and Obesity
- Body Composition Measurement Techniques
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Cardiovascular and exercise physiology
- Medication Adherence and Compliance
Karolinska Institutet
2015-2024
Karolinska University Hospital
2015-2024
Ljubljana University Medical Centre
2008
Stockholm University College of Music Education
2001-2007
Integrated Cardio Metabolic Centre
1990-2004
Umeå University
2001
Uppsala University Hospital
1997
Dapagliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, reduces hyperglycemia in patients with type diabetes mellitus (T2DM) by increasing urinary glucose excretion, and weight loss is consistent associated finding. Our objectives were to confirm dapagliflozin establish through body composition measurements whether accounted for changes fat or fluid components. This was 24-wk, international, multicenter, randomized, parallel-group, double-blind, placebo-controlled study...
<h3>Importance</h3> The majority of individuals with type 1 diabetes do not meet recommended glycemic targets. <h3>Objective</h3> To evaluate the effects continuous glucose monitoring in adults treated multiple daily insulin injections. <h3>Design, Setting, and Participants</h3> Open-label crossover randomized clinical trial conducted 15 outpatient clinics Sweden between February 24, 2014, June 1, 2016 that included 161 hemoglobin A<sub>1c</sub>(HbA<sub>1c</sub>) at least 7.5% (58 mmol/mol)...
Intensive self-management with frequent self-monitoring of blood glucose (SMBG) is important in type 1 diabetes to achieve good metabolic control (1–3). Nevertheless, many patients still experience episodes unrecognized hypo- and hyperglycemia (4). Novel technologies for continuous monitoring (CGM) that provide information about excursions are now available. Previous studies reported the benefits retrospective evaluation CGM data (5–11), but few assessed effects on glycemic (5,12–14), only...
To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes.In this randomized, controlled, multicenter study, 120 children and adults intensive therapy for diabetes a screening level glycated hemoglobin A(1c) (HbA(1c)) <7.5% were randomly assigned to control group performing conventional home blood meter wearing masked monitor every second week five days or real-time monitoring. The primary outcome was time spent (interstitial concentration <63...
The aim of this multicentre, randomised, controlled crossover study was to determine the efficacy adding continuous glucose monitoring (CGM) insulin pump therapy (CSII) in type 1 diabetes. Children and adults (n = 153) on CSII with HbA1c 7.5–9.5% (58.5–80.3 mmol/mol) were randomised a Sensor On or Off arm for 6 months. After 4 months' washout, participants crossed over other Paediatric adult separately electronically through case report form according predefined randomisation sequence eight...
Dapagliflozin, a highly selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycaemia and weight in patients with type diabetes mellitus (T2DM) by increasing urinary glucose excretion. Long-term glycaemic control, body composition bone safety were evaluated T2DM after 102 weeks dapagliflozin treatment.This randomized, double-blind, placebo-controlled study (NCT00855166) enrolled [mean: age 60.7 years; HbA1c 7.2%; mass index (BMI) 31.9 kg/m(2) ; 91.5 kg] inadequately...
The adrenergic regulation of lipolysis was investigated in situ at rest and during standardized bicycle exercise nonobese healthy subjects, using microdialysis the extracellular space subcutaneous adipose tissue. glycerol concentration about two times greater tissue than venous blood. At rest, rapidly increased by 100% (P less 0.01) after addition phentolamine to ingoing perfusate, whereas propranolol did not alter level. Glycerol plasma decreased postexercise period. Propranolol perfusate...
The possible existence of regional differences in the antilipolytic action insulin human adipose tissue was investigated vitro. Insulin-induced inhibition glycerol release and binding, measured terms receptor number, affinity, dissociation rates, were determined omental subcutaneous segments isolated fat cells 16 nonobese subjects who undergoing elective abdominal surgery but otherwise healthy. sensitivity effect higher than tissue; half-maximal obtained with 1 3 μU/ml insulin, respectively...
Background. The purpose of pancreatic transplantation in insulin-dependent diabetic patients is to restore normoglycemia and thereby prevent the secondary complications diabetes. However, uncertainty remains as whether mortality rate can be affected by this procedure. Method. We followed 14 with diabetes mellitus (IDDM) end-stage nephropathy for 10 years after successful combined kidney pancreas transplantation. Fifteen subjected alone have served controls. glycemic control has been studied...
Abstract Aims Dapagliflozin, a selective sodium‐glucose cotransporter 2 ( SGLT2 ) inhibitor, reduces hyperglycaemia in patients with type diabetes T2DM by increasing urinary glucose excretion. Owing to its mechanism of action, dapagliflozin could potentially affect the renal tubular transportation bone minerals. Therefore, markers formation and resorption mineral density BMD were evaluated after 50 weeks treatment. Methods This international, multi‐centre, randomized, parallel‐group,...
OBJECTIVE—To estimate the prevalence and severity of diabetic retinopathy (DR) 10 years after diagnosis in a nationwide population-based cohort study young adult patients Sweden. RESEARCH DESIGN AND METHODS—The Diabetes Incidence Study Sweden (DISS) aims to register all incident cases diabetes aged 15–34 In 1987–1988, 806 were reported, 627 (78%) them followed up with regard 8–10 later. The assessment was based on retinal photographs most (86%). RESULTS—Ten diagnosis, found 247 (39%). mild...
Insulin-dependent diabetes mellitus is an autoimmune disease in which the beta cells of islets Langerhans are selectively destroyed.1 In a patient with this disease, transplanted pancreas should be as susceptible to process native pancreas. Indeed, insulin-dependent can recur immunocompetent or minimally immunosuppressed recipient pancreatic transplant from identical twin HLA-identical sibling.2 Usually, however, degree immunosuppression required prevent rejection sufficient damage graft.3...
OBJECTIVE—C-peptide replacement in animals results amelioration of diabetes-induced functional and structural abnormalities peripheral nerves. The present study was undertaken to examine whether C-peptide administration patients with type 1 diabetes neuropathy improves sensory nerve function. RESEARCH DESIGN AND METHODS—This an exploratory, double-blinded, randomized, placebo-controlled three groups that carried out at five centers Sweden. given as a dose (1.5 mg/day, divided into four...
Evidence for the effectiveness of interstitial glucose monitoring in individuals with type 1 diabetes using multiple daily injection (MDI) therapy is limited. In this pre-specified subgroup analysis Novel Glucose-Sensing Technology and Hypoglycemia Type Diabetes: a Multicentre, Non-masked, Randomised Controlled Trial' (IMPACT), we assessed impact flash technology on hypoglycaemia compared capillary monitoring.This multicentre, prospective, non-masked, RCT enrolled adults from 23 European...
To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation time of diagnosis.A population-based prospective study with a mean annual population risk 2.3 million.All departments medicine, endocrinology paediatrics primary health care units in Sweden.Incident cases diabetes years diagnosis 1983-2002. MEASURE INSTRUMENT: Basic characteristics were reported by diagnosing doctor on...
We reassessed the validity of previously reported incidence rates for type 1 diabetes in 0-34 year olds Sweden. estimated new through three nationwide registers.We used capture-recapture methods to assess ascertainment Diabetes Incidence Study Sweden (DISS) and 20-34 age group 2007-2009. examined whether patients aged 34 younger could be Prescribed Drug Register (PDR) via a proxy diagnosis diabetes; men with at least one women prescriptions insulin were included if they had not been given...
To investigate the impact of continuous glucose monitoring (CGM) on health-related quality life (HRQOL), treatment satisfaction (TS) medical resource use, and indirect costs in SWITCH study. was a multicentre, randomized, crossover Patients with type 1 diabetes (n = 153) using subcutaneous insulin infusion (CSII) were randomized to 12 month sensor-On/Off or sensor-Off/On sequence (6 months each treatment), 4-month washout between periods. HRQOL children TS adults measured validated...