A5080534060- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- Climate Change and Health Impacts
- Retinal Diseases and Treatments
- Skin Protection and Aging
- Adrenal Hormones and Disorders
- Emergency and Acute Care Studies
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Diabetes Management and Education
- Air Quality and Health Impacts
- Retinal Imaging and Analysis
- SARS-CoV-2 and COVID-19 Research
- Regulation of Appetite and Obesity
Lund University
2016-2025
Skåne University Hospital
2015-2025
Hallands sjukhus Halmstad
2022
Uppsala University Hospital
2016
Helsingborgs lasarett
2011-2013
University of Washington
1992-1997
Karolinska University Hospital
1997
Umeå University
1996
Malmö University
1985-1995
Diabetes Australia
1988
The stimulation of insulin vs. inhibition glucagon secretion in relation to the antidiabetic action glucagon-like peptide-1 (GLP-1) is not established. Here, influence a 4-wk increase circulating GLP-1 by dipeptidyl peptidase-4 (DPP-4) on 24-h glucose and responses breakfast was studied subjects with dietary controlled diabetes [age: 65 +/- 8 yr (SD), body mass index: 27.3 3.3 kg/m(2), fasting plasma glucose: 9.0 1.3 mmol/liter]. Compared placebo (n = 19), specific DPP-4 inhibitor...
OBJECTIVE—Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the drawback of short half-life GLP-1, inhibitors GLP-1–degrading enzyme dipeptidyl peptidase IV (DPP IV) have examined. Such improve glucose tolerance in insulin-resistant rats and mice. In this study, we examined 4-week effect 1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine (NVP DPP728), selective, orally active inhibitor DPP IV, subjects...
Abstract Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric N ordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods conducted a randomized dietary study lasting for 18–24 weeks individuals features syndrome (mean age 55 years, BMI 31.6 kg m −2 , 67% women). Altogether 309 were screened, 200 started intervention after 4‐week run‐in period, 96...
<b>Objective</b> To investigate the long term effects of continuous subcutaneous insulin infusion (insulin pump therapy) on cardiovascular diseases and mortality in people with type 1 diabetes. <b>Design </b>Observational study. <b>Setting </b>Swedish National Diabetes Register, Sweden 2005-12. <b>Participants</b> 18 168 diabetes, 2441 using therapy 15 727 multiple daily injections. <b>Main outcome measures</b> Cox regression analysis was used to estimate hazard ratios for outcomes,...
OBJECTIVE—Insulin detemir is a soluble long-acting basal insulin analog designed to overcome the limitations of conventional formulations. Accordingly, has been compared with NPH respect glycemic control (HbA1c, prebreakfast glucose levels and variability, hypoglycemia) timing administration. RESEARCH DESIGN AND METHODS—People type 1 diabetes (n = 408) were randomized in an open-label, parallel-group trial 16-week treatment duration using either or insulin. Insulin was administered twice...
Most autoimmune diabetes occurs in those without a diabetic relative, but few cases are identifiable prospectively. To model general population prediction, 491 consecutive newly children from all of Sweden were tested for autoantibodies to glutamate decarboxylase (GAD65ab), insulin (IAA), and islet cells (ICA), HLA-DQ genotypes by PCR; 415 matched control parallel. GAD65ab sensitivity/specificity was 70/96%, versus 84/96% ICA, 56/97% IAA, 93/93% (any positive), 39/99.7% (all 41/99.7%...
Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, islet cells were determined by logistic regression analysis in 971 incident patients with 702 control subjects aged 0–34 years. GADAs associated HLA-DQ2 young but not older (P = 0.009). Autoantibodies insulin negatively age &lt; 0.0001) positively DQ8 0.03) VNTR 0.04), supporting possible immune tolerance induction. ICA512/IA-2 DQ2 0.04). Males...
At and before onset, most insulin-dependent diabetics (IDDM) have islet GAD65 autoantibodies (GAD65Ab). Since IDDM also occurs in older patients where non-insulin-dependent diabetes is common, we studied GAD65Ab at onset to classify type. Our quantitative immunoprecipitation assay uses recombinant human stably expressed hamster fibroblasts. Electrophoretic mobility was identical native GAD65. Like antigen, migrated as two bands during electrophoresis, but converted one under stronger...
OBJECTIVE—This study was conducted to determine the effects of vildagliptin on incretin hormone levels, islet function, and postprandial glucose control in subjects with impaired tolerance (IGT). RESEARCH DESIGN AND METHODS—A 12-week, double-blind, randomized, parallel-group comparing (50 mg q.d.) placebo 179 IGT (2-h 9.1 mmol/l, A1C 5.9%). Plasma levels intact glucagon-like peptide 1 (GLP-1) gastric inhibitory polypeptide (GIP), glucose, insulin, C-peptide, glucagon were measured during...
Abstract Objective Women with active sunlight exposure habits experience a lower mortality rate than women who avoid sun exposure; however, they are at an increased risk of skin cancer. We aimed to explore the differences in main causes death according exposure. Methods assessed as factor for all‐cause competing scenario 29 518 Swedish prospective 20‐year follow‐up Melanoma Southern Sweden ( MISS ) cohort. were recruited from 1990 1992 (aged 25–64 years start study). obtained detailed...
We reassessed the validity of previously reported incidence rates for type 1 diabetes in 0-34 year olds Sweden. estimated new through three nationwide registers.We used capture-recapture methods to assess ascertainment Diabetes Incidence Study Sweden (DISS) and 20-34 age group 2007-2009. examined whether patients aged 34 younger could be Prescribed Drug Register (PDR) via a proxy diagnosis diabetes; men with at least one women prescriptions insulin were included if they had not been given...
Sunlight exposure and fair skin are major determinants of human vitamin D production, but they also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality related to low levels.We assessed the avoidance sun as a factor 29 518 Swedish women in prospective 20-year follow-up Melanoma Southern Sweden (MISS) cohort. Women were recruited from 1990 1992 aged 25 64 years at start study. We obtained detailed information baseline on their habits...
Objective. This study was designed to determine whether a relationship exists between previous exposure measles, mumps, and rubella (MMR) by natural infection or vaccination new immunization with MMR vaccine, either the presence levels of autoantibodies against thyroid cell pancreatic β-cell antigens. Methods. Antibodies thyroglobulin, peroxidase, pancreas islet cells (ICA), surface, glutamic acid decarboxylase 65k autoantibodies, insulin were studied before, 3 months after, combined vaccine...
Autoantibodies to the islet-specific zinc transporter isoform 8 (ZnT8) are detected in majority of type 1 diabetes patients prior and at clinical diagnosis. The presence ZnT8Ab after diagnosis has not been investigated. This study analyzed autoantibody response ZnT8 regard age onset disease duration. Two new patient cohorts with different distributions (2–17 15–34 years onset), a longitudinal subset younger cohort (n = 32), GAD65Ab-positive LADA 47) was for autoantibodies directed two major...
Objective The aim of this study was to explore the associations between inadequate glycemic control diabetes and psychological, anthropometric, lifestyle variables in a population-based cohort type 1 patients. Design Cross-sectional study. Methods In study, 292 patients with diabetes, aged 18–59 years, participated. Psychological data were assessed by self-report instruments: Hospital Anxiety Depression Scale Toronto Alexithymia Scale-20. Anthropometrics, blood analyses, from medical...
Studies of the clinical and immunological features autoimmune Addison disease (AAD) are needed to understand burden increased mortality.To provide upgraded data on comorbidities, replacement therapy, autoantibody profiles, cardiovascular risk factors.A cross-sectional, population-based study that included 660 AAD patients from Swedish Registry (2008-2014). When analyzing factors, 3594 individuals survey in Northern Sweden, MONICA (monitoring trends determinants disease), served as...
Diabetes during pregnancy is an increasingly common metabolic disorder, associated with significantly increased risks for both mother and child. Aim of this study was to compare maternal perinatal outcomes in women pregestational (PDM) type 1 (T1DM), 2 diabetes (T2DM), gestational mellitus (GDM) these pregnancies not complicated diabetes. This also evaluated a specifically organized care-model mostly involving specialist nurses. Retrospective population-based records review 2009–2012. Rates...
Patients with autoimmune polyendocrine syndrome type I (APS I) have autoantibodies against the enzyme aromatic l-amino acid decarboxylase (AADC) of pancreatic β-cells. The aim present study was to investigate presence anti-AADC antibodies in a large cohort patients APS I, and isolated insulin-dependent diabetes mellitus (IDDM). We found AADC 35 69 (51%) but none 138 IDDM or 91 healthy controls. Among were more often those hepatitis (11/12, 92%), than without (24/57, 42%) (P = 0.003)....
OBJECTIVE— To determine the effects of islet cell antibodies on β-cell function during first 3 yr after diagnosis in type II diabetic patients. RESEARCH DESIGN AND METHODS— patients with (n = 11, 50 ± 5 age) and without 10, 52 4 ICA was followed prospectively compared I adult 17, 37 healthy control subjects 34, age 45 yr). evaluated as fasting C-peptide, 1 + min C-peptide intravenous glucose, ∆ glucagon. RESULTS— Fasting equal (0.30 0.03 nM) (0.24 at diagnosis, decreased (P &lt; 0.05)...
The effect of age on ICA and thyrogastric antibodies at diagnosis IDDM was evaluated in 633 consecutively diagnosed Swedish diabetic patients aged 15–34 yr 282 volunteers the same age. ICAs were present 61% (383 633) 2% (5 282) control subjects. When initial classification considered, detected 69% (327 473) with IDDM, 23% (19 83) those NIDDM, 50% (36 72) unclassifiable diabetes, 20% (1 5) secondary diabetes. frequency fell significantly (P &lt; 0.001) from 77% (104/135) 15–19 old to 52%...