A5084607207- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Glutathione Transferases and Polymorphisms
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Receptor Mechanisms and Signaling
- Hormonal and reproductive studies
- Diet, Metabolism, and Disease
- Nicotinic Acetylcholine Receptors Study
- Chemical Reactions and Isotopes
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Synthesis and Biological Evaluation
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Diabetes Treatment and Management
- Obesity, Physical Activity, Diet
- Lipoproteins and Cardiovascular Health
- Statistical Methods in Clinical Trials
- Smoking Behavior and Cessation
University of Oulu
2015-2025
Oulu University Hospital
2015-2025
Biocenter Finland
2015-2020
University of Eastern Finland
2014
Kuopio University Hospital
2014
University of California, San Francisco
2005-2009
San Francisco General Hospital
2005-2009
Lapland Central Hospital
2006
Pharmac
2005
Abstract Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric N ordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods conducted a randomized dietary study lasting for 18–24 weeks individuals features syndrome (mean age 55 years, BMI 31.6 kg m −2 , 67% women). Altogether 309 were screened, 200 started intervention after 4‐week run‐in period, 96...
Abstract Aims To assess whether implementation of the 2019 European Society Cardiology (ESC)/European Atherosclerosis (EAS) dyslipidaemia guidelines observed between 2020 and 2021 improved 2022 in SANTORINI study. Methods results Patients with high or very cardiovascular (CV) risk were recruited across 14 countries from March to February 2021, 1-year prospective follow-up until May 2022. Lipid-lowering therapy (LLT) ESC/EAS risk-based low-density lipoprotein (LDL) cholesterol (LDL-C) goal...
Several cytochrome P450 (CYP) enzymes are expressed in the human lung, where they participate metabolic inactivation and activation of numerous exogenous endogenous compounds. In this study, expression pattern all known xenobiotic-metabolizing CYP genes was characterized alveolar type II cell-derived A549 adenocarcinoma cell line using qualitative reverse transcriptase/polymerase chain reaction (RT-PCR). addition, mechanisms induction by chemicals members CYP1 CYP3A subfamilies were assessed...
Expression in the lung of procarcinogen-metabolizing P450 enzymes CYP3A subfamily may contribute to initiation pulmonary carcinogenesis by agents that require metabolic activation, such as tobacco-derived polycyclic aromatic hydrocarbons. and localization CYP3A4 CYP3A5 proteins human were determined immunohistochemistry with three antibodies, one specific for members two antipeptide antibodies CYP3A5, respectively. Positive immunostaining or several cell types was observed all patients...
We conducted a randomized, open, placebo-controlled crossover trial to investigate the effects of pregnane X receptor (PXR) agonist rifampin on an oral glucose tolerance test (OGTT) in 12 healthy volunteers. The subjects were administered 600 mg or placebo once daily for 7 days, and OGTT was performed eighth day. mean incremental insulin areas under plasma concentration–time curves (AUCincr) increased by 192% (P = 0.008) 45% 0.031), respectively. fasting glucose, insulin, C-peptide,...
Background and Purpose Many drugs environmental contaminants induce hypercholesterolemia promote the risk of atherosclerotic cardiovascular disease. We tested hypothesis that pregnane X receptor (PXR), a xenobiotic‐sensing nuclear receptor, regulates level circulating atherogenic lipids in humans utilized mouse experiments to identify mechanisms involved. Experimental Approach performed serum NMR metabolomics healthy volunteers administered rifampicin, prototypical human PXR ligand or...
Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility pulmonary carcinogenesis. This study was designed determine effects smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation bronchoalveolar macrophages (BAM) 31 smokers 16 non-smokers. CYP protein levels were determined by immunoblotting nuclease P1...
CYP3A5 is the major CYP3A form in human lung, and it inducible by dexamethasone A549 lung adenocarcinoma cell line. In present study, we characterized nature mechanism of this induction process. The mRNA was assessed quantitative reverse transcriptase-polymerase chain reaction cells. About 4-fold detected nanomolar concentrations also budenoside beclomethasone dipropionate, glucocorticoids used for inhalation treatment bronchial asthma, whereas CYP3A4 inducers mifepristone (RU486),...
Human pulmonary tissues are known to contain enzymes mediating procarcinogen activation. Peripheral blood lymphocytes and bronchoalveolar macrophages (BAMs) have been used as surrogates for the lung in studies involving cytochrome P450 (CYP) parameters, including CYP1A1 inducibility relation susceptibility cancer. In this study, a comprehensive view of expression patterns xenobiotic-metabolizing CYP forms human BAMs peripheral was obtained by using gene-specific reverse...