A5062146319- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Carcinogens and Genotoxicity Assessment
- Drug-Induced Hepatotoxicity and Protection
- Eicosanoids and Hypertension Pharmacology
- Toxic Organic Pollutants Impact
- Metabolism and Genetic Disorders
- Glutathione Transferases and Polymorphisms
- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- Metabolomics and Mass Spectrometry Studies
- Pesticide Exposure and Toxicity
- Computational Drug Discovery Methods
- Chemical Reactions and Isotopes
- Analytical Chemistry and Chromatography
- Pharmacological Effects and Toxicity Studies
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Prenatal Substance Exposure Effects
- DNA and Nucleic Acid Chemistry
- Cancer Treatment and Pharmacology
- Amino Acid Enzymes and Metabolism
- Synthesis and Biological Evaluation
- Polyamine Metabolism and Applications
- Pesticide and Herbicide Environmental Studies
University of Oulu
2014-2023
Oulu University Hospital
1978-2019
University of Helsinki
1973-2018
Oulu Deaconess Institute
1995-2018
University of Eastern Finland
1992-2002
Institute of Pharmacology
2002
Finnish Medicines Agency Fimea
1998
Shinshu University
1997
Odense University Hospital
1995
Åbo Akademi University
1993
Objectives The effect of aging on drug metabolism in humans has not yet been completely described. Methods Two hundred twenty-six patients with equal histopathologic conditions were investigated. cytochrome P450 contents the liver biopsy samples, plasma antipyrine clearance rates after oral administration and, as an independent control vitality, serum testosterone levels determined. Results Cytochrome content subjects from 20 to 29 years age was 7.2 ± 2.6 nmol · gm−1, increased during fourth...
Cytochrome P450 2A6 is an important human hepatic which activates pre‐carcinogens, oxidises some drugs and constitutes the major nicotine C ‐oxidase. In fact, results have been presented in literature suggested a relationship between distribution of defective CYP2A6 alleles smoking behaviour as well cigarette consumption. present report, we describe structure novel CYP2A locus where whole gene has deleted, resulting abolished cytochrome 2A6‐dependent metabolism. The origin this apparently...
Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion state of art Toxicokinetic/Toxicodynamic (TKTD) models use in prospective environmental risk assessment (ERA) for pesticides aquatic organisms. TKTD are species- compound-specific can be used to predict (sub)lethal effects under untested (time-variable) exposure conditions. Three different types described, viz., (i) 'General Unified Threshold Survival' (GUTS), (ii) those based...
The polymorphic human cytochrome P450 2A6 (CYP2A6) metabolises a number of drugs, activates variety precarcinogens and constitutes the major nicotine C ‐oxidase. A relationship between CYP2A6 genotype smoking habits, as well incidence lung cancer, has been proposed. Two defective alleles have hitherto identified, one which is very common in Asian populations. Among Caucasians, an additional frequently distributed allele ( CYP2A6*3 ) suggested to play protective role against addiction...
Several cytochrome P450 (CYP) enzymes are expressed in the human lung, where they participate metabolic inactivation and activation of numerous exogenous endogenous compounds. In this study, expression pattern all known xenobiotic-metabolizing CYP genes was characterized alveolar type II cell-derived A549 adenocarcinoma cell line using qualitative reverse transcriptase/polymerase chain reaction (RT-PCR). addition, mechanisms induction by chemicals members CYP1 CYP3A subfamilies were assessed...
Cytochrome P450 2A6 (CYP2A6) is a polymorphic enzyme responsible for the oxidation of certain precarcinogens and drugs major nicotine C-oxidase. The role CYP2A6 elimination was emphasised recently by finding that smokers carrying defective alleles consumed fewer cigarettes [Pianezza et al. (1998) Nature 393, 750]. method used genotyping has, however, been found to give erroneous results with respect coumarin hydroxylase phenotype, probe reaction enzyme. present study describes an...
1. Fluvoxamine and seven other selective serotonin reuptake inhibitors (SRRI) were tested for their ability to inhibit a number of human cytochrome P450 isoforms (CYPs). 2. None the drugs showed potent inhibition CYP2A6 (coumarin 7‐hydroxylase) or CYP2E1 (chlorzoxazone 6‐hydroxylase), while norfluoxetine was only inhibitor CYP3A having IC50 values 11 microM 19 testosterone 6 beta‐hydroxylase cortisol beta‐hydroxylase, respectively. 3. Norfluoxetine, sertraline fluvoxamine inhibited CYP1A1...
Expression in the lung of procarcinogen-metabolizing P450 enzymes CYP3A subfamily may contribute to initiation pulmonary carcinogenesis by agents that require metabolic activation, such as tobacco-derived polycyclic aromatic hydrocarbons. and localization CYP3A4 CYP3A5 proteins human were determined immunohistochemistry with three antibodies, one specific for members two antipeptide antibodies CYP3A5, respectively. Positive immunostaining or several cell types was observed all patients...