A5049490122- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Agricultural safety and regulations
- Estrogen and related hormone effects
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Pesticide Residue Analysis and Safety
- DNA and Nucleic Acid Chemistry
- bioluminescence and chemiluminescence research
- Pesticide and Herbicide Environmental Studies
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- Consumer Attitudes and Food Labeling
- Radiation Effects and Dosimetry
- Chemical Analysis and Environmental Impact
- Pharmacogenetics and Drug Metabolism
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Glutathione Transferases and Polymorphisms
- Free Radicals and Antioxidants
- Genetically Modified Organisms Research
- Computational Drug Discovery Methods
- Ovarian cancer diagnosis and treatment
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
University of Bologna
2007-2022
Agenzia Regionale Prevenzione e Ambiente della Regione Emilia-Romagna
2005-2021
Public Health England
2021
Regione Emilia-Romagna
2005
University of Genoa
1993
Centro Interuniversitario di Ricerca Per lo Sviluppo sostenibile
1989-1990
Università degli Studi Internazionali di Roma
1988
Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion science behind risk assessment of plant protection products for in-soil organisms.The current scheme is reviewed, taking into account new regulatory frameworks scientific developments.Proposals are made specific goals organisms being key drivers relevant ecosystem services in agricultural landscapes such as nutrient cycling, soil structure, pest control biodiversity.Considering...
Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion state of art Toxicokinetic/Toxicodynamic (TKTD) models use in prospective environmental risk assessment (ERA) for pesticides aquatic organisms. TKTD are species- compound-specific can be used to predict (sub)lethal effects under untested (time-variable) exposure conditions. Three different types described, viz., (i) 'General Unified Threshold Survival' (GUTS), (ii) those based...
Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion science to support potential development of risk assessment scheme plant protection products for amphibians reptiles. The coverage reptiles by current assessments other vertebrate groups was investigated. Available test methods exposure models were reviewed with regard applicability Proposals made specific goals aiming protect important ecosystem services taking into consideration...
The cytoplasmic receptors for 17 beta-estradiol (ER), 5 alpha-dihydrotestosterone (AR), progesterone (PR), and cortisol (GR) have been quantified in 36 specimens from the human ovary (13 disease-free, benign, 18 malignant) by a dextran-coated charcoal (DCC) technique. occurrence of receptor-positive biopsies were: ER 46%, AR 85%, PR 54%, GR 92%, normal tissue; 40%, 100%, 20%, 50%, benign tumors; 67%, 72%, 88%, malignant lesions. Furthermore, simultaneous tumors was 50% yet all four were...
EFSA JournalVolume 15, Issue 3 e04691 Scientific OpinionOpen Access Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia† Panel on Plant Protection Products their residues (PPR), (PPR)Search for more papers by this authorColin Ockleford, Colin OcklefordSearch authorPaulien Adriaanse, Paulien AdriaanseSearch authorPhilippe Berny, Philippe BernySearch authorTheodorus Brock, Theodorus...
In 2013, EFSA published a comprehensive systematic review of epidemiological studies from 2006 to 2012 investigating the association between pesticide exposure and many health outcomes. Despite considerable amount information available, quality much this evidence was rather low limitations likely affect results so firm conclusions cannot be drawn. Studies that do not meet 'recognised standards' mentioned in Regulation (EU) No 1107/2009 are thus suited for risk assessment. Scientific Opinion,...
The development of alternative methods to animal testing is a priority in the context regulatory toxicology. Carcinogenesis field where demand for particularly high. standard rodent carcinogenicity bioassay requires large use animals, high costs, prolonged duration and shows several limitations, which can affect comprehension human relevance carcinogenesis. cell transformation assay (CTA) has long been debated as possible vitro test study This provides an easily detectable endpoint...
Following a request from the European Commission, EFSA Panel on Plant Protection Products and their Residues (PPR Panel) prepared scientific opinion to provide comprehensive evaluation of pesticide residues in foods for infants young children. In its approach develop this opinion, PPR took into account, among others, (i) relevant opinions Scientific Committee Food setting default maximum residue level (MRL) 0.01 mg/kg children; (ii) recommendations provided by guidance risk assessment...
Abstract 14 C‐labelled carbon tetrachloride binds in vivo to DNA of mouse liver and r RNA rat if the animals have been pretreated with 3‐methylcholanthrene. A noticeable amount radioactivity is also observed proteins. In vitro activated by microsomes pH 5 enzymes 3‐methylcholanthrene‐treated a metabolite which can react polynucleotides; this effect more evident subcellular fractions from are used.
Abstract Cytotoxic and cell transforming activities of the pesticides cyanazine, diflubenzuron, dithianon, procymidone, vinclozolin were investigated in vitro by utilizing BALB/c 3T3 transformation test performed presence or absence S‐9 mix as an exogenous bioactivation system for chemicals. All assayed cytotoxic mix, whereas only dithianon exerted effects metabolic activation. chemicals tested did induce transformation, to a various extent, mix. Cell ability cyanazine diflubenzuron was not...
The glucocorticoid receptor (GR) quantitation by a whole-cell assay and/or cytosol technique and the in vitro sensitivity to steroids have been assessed peripheral blood cells from normal donors patients with chronic lymphatic leukemia (CLL), acute lymphoblastic (ALL), lymphosarcoma cell (LSCL), nonlymphatic (ANLL), myeloid (CML). Within lymphoproliferative diseases, ALL exhibited highest GR concentration (regardless of method used) inhibition spontaneous [3H]thymidine ([3H]TdR) uptake...
The use of nuclear resources for medical purposes causes considerable concern about occupational exposure. Nevertheless, little information is available regarding the effects low-dose irradiations protracted over time. We used oligomicroarrays to identify genes that are transcriptionally regulated by persistent exposure extremely low doses ionizing radiation in 28 exposed professionals (mean cumulative effective dose ± SD, 19 38 mSv) compared with a matched sample nonexposed subjects....
Using the value of 0.24 fmoles/microgram DNA as breaking point between high and low binding capacities, we quantified receptors for 17 beta-estradiol (ER), 5 alpha-dihydrotestosterone (DHTR), progesterone (PR) cortisol (CR) in normal neoplastic human uterine tissues. Concerning occurrence, significant relationships were observed ER PR, DHTR, DHTR PR. A direct correlation presence tumor grading was found: PR less frequent grade II absent III endometrial carcinoma, however this not a...
Five pesticides [amitraz, cyanazine, cyhexatin, dinitro-o-cresol (DNOC), and fenarimol] were tested as pure active ingredients for in vivo induction of DNA strand breaks on rat hepatocytes after intraperitoneal (ip) treatment. Two pesticides, fenarimol DNOC, capable inducing damage because they significantly increased the unwinding rate. On contrary, amitraz, cyhexatin not DNA-damaging agents.